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The aim of this paper is to provide a comprehensive review of statistical challenges in neuroimaging data analysis from neuroimaging techniques to large-scale neuroimaging studies to statistical learning methods. We briefly review eight…

Applications · Statistics 2022-10-18 Hongtu Zhu , Tengfei Li , Bingxin Zhao

In recent years, it has become common practice in neuroscience to use networks to summarize relational information in a set of measurements, typically assumed to be reflective of either functional or structural relationships between regions…

Applications · Statistics 2017-03-20 Cedric E. Ginestet , Jun Li , Prakash Balachandran , Steven Rosenberg , Eric D. Kolaczyk

Normative modelling is an increasingly common statistical technique in neuroimaging that estimates population-level benchmarks in brain structure. It enables the quantification of individual deviations from expected distributions whilst…

Neurons and Cognition · Quantitative Biology 2025-10-21 Nida Alyas , Jonathan Horsley , Bethany Little , Peter N. Taylor , Yujiang Wang , Karoline Leiberg

While quantum architectures are still under development, when available, they will only be able to process quantum data when machine learning algorithms can only process numerical data. Therefore, in the issues of classification or…

Machine Learning · Computer Science 2025-12-16 Rafal Potempa , Sebastian Porebski

Standard neuroimaging data analysis based on traditional principles of experimental design, modelling, and statistical inference is increasingly complemented by novel analysis methods, driven e.g. by machine learning methods. While these…

Neurons and Cognition · Quantitative Biology 2018-09-27 Kai Görgen , Martin N. Hebart , Carsten Allefeld , John-Dylan Haynes

It is proposed to investigate the onset of a disease D, based on several risk factors., with a specific interest in Alzheimer occurrence. For that purpose, two classes of techniques are available, whose properties are quite different in…

Applications · Statistics 2023-01-18 C. Huber

Many experimental paradigms in neuroscience involve driving the nervous system with periodic sensory stimuli. Neural signals recorded using a variety of techniques will then include phase-locked oscillations at the stimulation frequency.…

Methodology · Statistics 2021-08-30 Daniel H. Baker

Neuroimaging meta-analysis is an area of growing interest in statistics. The special characteristics of neuroimaging data render classical meta-analysis methods inapplicable and therefore new methods have been developed. We review existing…

Applications · Statistics 2017-11-30 Pantelis Samartsidis , Silvia Montagna , Thomas E. Nichols , Timothy D. Johnson

We investigate the relationship between two distinct classical approaches to quantum systems: direct simulation from a classical description and sample-based learning from measurement data. While both tasks ultimately aim to reproduce…

Quantum Physics · Physics 2026-05-29 João Pedro Del Rey , Raúl O. Vallejos , Fernando de Melo

Studying the reliability of complex systems using machine learning techniques involves facing a series of technical and practical challenges, ranging from the intrinsic nature of the system and data to the difficulties in modeling and…

Machine Learning · Computer Science 2024-10-08 Maria Luz Gamiz , Fernando Navas-Gomez , Rafael Nozal-Cañadas , Rocio Raya-Miranda

Recent experimental advances in neuroscience have opened new vistas into the immense complexity of neuronal networks. This proliferation of data challenges us on two parallel fronts. First, how can we form adequate theoretical frameworks…

Neurons and Cognition · Quantitative Biology 2015-06-12 Madhu Advani , Subhaneil Lahiri , Surya Ganguli

Neuroimaging has profoundly enhanced our understanding of the human brain by characterizing its structure, function, and connectivity through modalities like MRI, fMRI, EEG, and PET. These technologies have enabled major breakthroughs…

Applications · Statistics 2026-02-16 Jian Kang , Thomas Nichols , Lexin Li , Martin A. Lindquist , Hongtu Zhu

Data scientists and statisticians are often at odds when determining the best approach, machine learning or statistical modeling, to solve an analytics challenge. However, machine learning and statistical modeling are more cousins than…

Machine Learning · Computer Science 2022-01-10 Michele Bennett , Karin Hayes , Ewa J. Kleczyk , Rajesh Mehta

Recent years have seen significant activity on the problem of using data for the purpose of learning properties of quantum systems or of processing classical or quantum data via quantum computing. As in classical learning, quantum learning…

Quantum Physics · Physics 2024-04-17 Leonardo Banchi , Jason Luke Pereira , Sharu Theresa Jose , Osvaldo Simeone

Comparisons of different treatments or production processes are the goals of a significant fraction of applied research. Unsurprisingly, two-sample problems play a main role in Statistics through natural questions such as `Is the the new…

Methodology · Statistics 2017-09-05 P. C. Álvarez-Esteban , E. del Barrio , J. A. Cuesta-Albertos , C. Matrán

Complex statistical models such as scalar-on-image regression often require strong assumptions to overcome the issue of non-identifiability. While in theory it is well understood that model assumptions can strongly influence the results,…

Methodology · Statistics 2020-05-04 Clara Happ , Sonja Greven , Volker J. Schmid

The study of random networks in a neuroscientific context has developed extensively over the last couple of decades. By contrast, techniques for the statistical analysis of these networks are less developed. In this paper, we focus on the…

Neurons and Cognition · Quantitative Biology 2017-07-11 Daniel Fraiman , Ricardo Fraiman

A coordinate system is a foundation for every quantitative science, engineering, and medicine. Classical physics and statistics are based on the Cartesian coordinate system. The classical probability and hypothesis testing theory can only…

Methodology · Statistics 2022-11-08 Kai Zhang , Shan Liu , Momiao Xiong

Longitudinal studies, where a series of images from the same set of individuals are acquired at different time-points, represent a popular technique for studying and characterizing temporal dynamics in biomedical applications. The classical…

Image and Video Processing · Electrical Eng. & Systems 2023-04-18 Heejong Kim , Mert R. Sabuncu

The last decades saw dramatic progress in brain research. These advances were often buttressed by probing single variables to make circumscribed discoveries, typically through null hypothesis significance testing. New ways for generating…

Neurons and Cognition · Quantitative Biology 2019-03-26 Danilo Bzdok , John Ioannidis
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