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The thesis explores the role machine learning methods play in creating intuitive computational models of neural processing. Combined with interpretability techniques, machine learning could replace human modeler and shift the focus of human…

Neurons and Cognition · Quantitative Biology 2020-10-20 Ilya Kuzovkin

While concept-based interpretability methods have traditionally focused on local explanations of neural network predictions, we propose a novel framework and interactive tool that extends these methods into the domain of mechanistic…

Machine Learning · Computer Science 2025-07-09 Sofiia Chorna , Kateryna Tarelkina , Eloïse Berthier , Gianni Franchi

The problem of knowledge graph (KG) reasoning has been widely explored by traditional rule-based systems and more recently by knowledge graph embedding methods. While logical rules can capture deterministic behavior in a KG they are brittle…

Artificial Intelligence · Computer Science 2020-09-24 Susheel Suresh , Jennifer Neville

Learning an explainable classifier often results in low accuracy model or ends up with a huge rule set, while learning a deep model is usually more capable of handling noisy data at scale, but with the cost of hard to explain the result and…

Artificial Intelligence · Computer Science 2022-11-11 Yuanlong Li , Gaopan Huang , Min Zhou , Chuan Fu , Honglin Qiao , Yan He

Meta-learning, or learning-to-learn, seeks to design algorithms that can utilize previous experience to rapidly learn new skills or adapt to new environments. Representation learning -- a key tool for performing meta-learning -- learns a…

Machine Learning · Computer Science 2022-01-04 Nilesh Tripuraneni , Chi Jin , Michael I. Jordan

Discovery gene-disease links is important in biology and medicine areas, enabling disease identification and drug repurposing. Machine learning approaches accelerate this process by leveraging biological knowledge represented in ontologies…

Machine Learning · Computer Science 2025-04-14 Catarina Canastra , Cátia Pesquita

With good explanatory power and controllability, rule-based methods play an important role in many tasks such as knowledge reasoning and decision support. However, existing studies primarily focused on learning chain-like rules, which limit…

Artificial Intelligence · Computer Science 2025-01-07 Wangtao Sun , Shizhu He , Jun Zhao , Kang Liu

This paper gives an introduction to rule-based modelling applied to topics in infectious diseases. Rule-based models generalise reaction-based models with reagents that have internal state and may be bound together to form complexes, as in…

Populations and Evolution · Quantitative Biology 2021-08-10 William Waites , Matteo Cavaliere , David Manheim , Jasmina Panovska-Griffiths , Vincent Danos

Complex node interactions are common in knowledge graphs, and these interactions also contain rich knowledge information. However, traditional methods usually treat a triple as a training unit during the knowledge representation learning…

Computation and Language · Computer Science 2021-10-01 Bin He , Di Zhou , Jinghui Xiao , Xin jiang , Qun Liu , Nicholas Jing Yuan , Tong Xu

Learning-based signal processing systems increasingly support high-stakes medical decisions using heterogeneous biomedical signals, including medical images, physiological time series, and clinical records. Despite strong predictive…

Signal Processing · Electrical Eng. & Systems 2026-03-02 Surajit Das , Maxine Tan

Knowledge graphs (KGs) play a crucial role in many applications, such as question answering, but incompleteness is an urgent issue for their broad application. Much research in knowledge graph completion (KGC) has been performed to resolve…

Artificial Intelligence · Computer Science 2023-01-10 Yinyu Lan , Shizhu He , Kang Liu , Jun Zhao

Embedding learning, a.k.a. representation learning, has been shown to be able to model large-scale semantic knowledge graphs. A key concept is a mapping of the knowledge graph to a tensor representation whose entries are predicted by models…

Machine Learning · Computer Science 2015-12-23 Cristóbal Esteban , Volker Tresp , Yinchong Yang , Stephan Baier , Denis Krompaß

Metabolic networks, formed by a series of metabolic pathways, are made of intracellular and extracellular reactions that determine the biochemical properties of a cell, and by a set of interactions that guide and regulate the activity of…

Logic in Computer Science · Computer Science 2020-08-24 Jean-Marc Alliot , Marta Cialdea Mayer , Robert Demolombe , Martín Diéguez , Luis Fariñas del Cerro

When designing genetic circuits, the typical primitives used in major existing modelling formalisms are gene interaction graphs, where edges between genes denote either an activation or inhibition relation. However, when designing…

Computational Engineering, Finance, and Science · Computer Science 2015-01-05 Andreea Beica , Calin Guet , Tatjana Petrov

We consider the task of few shot link prediction on graphs. The goal is to learn from a distribution over graphs so that a model is able to quickly infer missing edges in a new graph after a small amount of training. We show that current…

Machine Learning · Computer Science 2020-03-03 Avishek Joey Bose , Ankit Jain , Piero Molino , William L. Hamilton

In this thesis, we study the problem of feature learning on heterogeneous knowledge graphs. These features can be used to perform tasks such as link prediction, classification and clustering on graphs. Knowledge graphs provide rich…

Machine Learning · Computer Science 2018-09-11 Sebastian Bischoff

We present a framework for learning disentangled representation of CapsNet by information bottleneck constraint that distills information into a compact form and motivates to learn an interpretable factorized capsule. In our $\beta$-CapsNet…

Computer Vision and Pattern Recognition · Computer Science 2022-09-13 Ming-fei Hu , Jian-wei Liu

To leverage machine learning in any decision-making process, one must convert the given knowledge (for example, natural language, unstructured text) into representation vectors that can be understood and processed by machine learning model…

Machine Learning · Computer Science 2023-07-11 Shibo Yao

A common problem of classical neural network architectures is that additional information or expert knowledge cannot be naturally integrated into the learning process. To overcome this limitation, we propose a two-step approach consisting…

Machine Learning · Computer Science 2024-06-17 Florian Seiffarth

Understanding how small molecules perturb gene expression is essential for uncovering drug mechanisms, predicting off-target effects, and identifying repurposing opportunities. While prior deep learning frameworks have integrated multimodal…

Machine Learning · Computer Science 2026-01-01 Pascal Passigan , Kevin Zhu , Angelina Ning