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Detecting microbial biomarkers used to predict disease phenotypes and clinical outcomes is crucial for disease early-stage screening and diagnosis. Most methods for biomarker identification are linear-based, which is very limited as…

Quantitative Methods · Quantitative Biology 2021-09-29 Jian Jiang

Micropatterning techniques have become an important tool for the study of cell behavior in controlled microenvironments. As a consequence, several approaches for the creation of micropatterns have been developed in recent years. However,…

Biological Physics · Physics 2016-02-05 F. J. Segerer , P. J. F. Röttgermann , S. Schuster , A. Piera Alberola , S. Zahler , J. O. Rädler

Building applications that perceive the world around them is challenging. A developer needs to (a) select and develop corresponding machine learning algorithms and models, (b) build a series of prototypes and demos, (c) balance resource…

Multiplexed imaging data are revolutionizing our understanding of the composition and organization of tissues and tumors. A critical aspect of such tissue profiling is quantifying the spatial relationship relationships among cells at…

Quantitative Methods · Quantitative Biology 2024-05-06 Ajit J. Nirmal , Peter K. Sorger

Raman spectroscopy is a non-destructive and label-free chemical analysis technique, which plays a key role in the analysis and discovery cycle of various branches of science. Nonetheless, progress in Raman spectroscopic analysis is still…

2D materials find promising applications in next-generation devices, however, large-scale, low-defect, and reproducible synthesis of 2D materials remains a challenging task. To assist in the selection of suitable substrates for the…

Materials Science · Physics 2021-12-08 Tara M. Boland , Arunima K. Singh

Graphical user interface (GUI) has become integral to modern society, making it crucial to be understood for human-centric systems. However, unlike natural images or documents, GUIs comprise artificially designed graphical elements arranged…

Computer Vision and Pattern Recognition · Computer Science 2025-03-19 Ziwei Wang , Weizhi Chen , Leyang Yang , Sheng Zhou , Shengchu Zhao , Hanbei Zhan , Jiongchao Jin , Liangcheng Li , Zirui Shao , Jiajun Bu

Novel technologies and new materials are in high demand for future energy-efficient electronic devices to overcome the fundamental limitations of miniaturization of current silicon-based devices. Two-dimensional (2D) materials show…

Computational Physics · Physics 2021-12-20 Lei Shen , Jun Zhou , Tong Yang , Ming Yang , Yuan Ping Feng

Metasurfaces are ultrathin, engineered materials composed of nanostructures that manipulate light in ways unattainable by natural materials. Recent advances have leveraged computational optimization, machine learning, and deep learning to…

Optics · Physics 2025-08-08 Hao Li , Andrey Bogdanov

By coupling peptides with DNA tags (i.e., 'barcodes'), it is now possible to harness high-throughput sequencing (HTS) technologies to enable highly multiplexed peptide-based assays, which have a variety of potential applications including…

Quantitative Methods · Quantitative Biology 2020-07-13 Zane W. Fink , Vidal Martinez , John Altin , Jason T. Ladner

Selecting third-party software packages in open-source ecosystems like Python is challenging due to the large number of alternatives and limited transparent evidence for comparison. Generative AI tools are increasingly used in development…

The Open Knowledgebase of Interatomic Models (OpenKIM) is an NSF Science Gateway that archives fully functional computer implementations of interatomic models (potentials and force fields) and simulation codes that use them to compute…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-05-31 Daniel S. Karls , Steven M. Clark , Brendon A. Waters , Ryan S. Elliott , Ellad B. Tadmor

Multimodal LLMs (MLLMs) are capable of performing complex data analysis, visual question answering, generation, and reasoning tasks. However, their ability to analyze biometric data is relatively underexplored. In this work, we investigate…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Ekta Gavas , Sudipta Banerjee , Chinmay Hegde , Nasir Memon

pPython seeks to provide a parallel capability that provides good speed-up without sacrificing the ease of programming in Python by implementing partitioned global array semantics (PGAS) on top of a simple file-based messaging library…

Crystalline interfaces are of highly importance in many practical applications. To conduct effective simulation and analysis for coincident site lattice (CSL) interfaces, effective programmes are of high demand in building their CSL…

Materials Science · Physics 2022-11-29 Yaoshu Xie , Kiyou Shibata , Teruyasu Mizoguchi

The true power of computational research typically can lay in either what it accomplishes or what it enables others to accomplish. In this work, both avenues are simultaneously embraced across several distinct efforts existing at three…

Materials Science · Physics 2024-11-06 Adam M. Krajewski

We present an open-source simulation framework for optically detected magnetic resonance, developed in Python. The framework allows users to construct, manipulate, and evolve multipartite quantum systems that consist of spins and electronic…

Quantum Physics · Physics 2025-01-13 Laura A. Völker , John M. Abendroth , Christian L. Degen , Konstantin Herb

Integrated Computational Materials Engineering (ICME) aims to accelerate optimal design of complex material systems by integrating material science and design automation. For tractable ICME, it is required that (1) a structural feature…

Materials Science · Physics 2017-05-01 Ruijin Cang , Yaopengxiao Xu , Shaohua Chen , Yongming Liu , Yang Jiao , Max Yi Ren

Microstructure characterization and reconstruction (MCR) is an important prerequisite for empowering and accelerating integrated computational materials engineering. Much progress has been made in MCR recently, however, in absence of a…

Materials Science · Physics 2022-07-12 Paul Seibert , Alexander Raßloff , Karl Kalina , Marreddy Ambati , Markus Kästner

Understanding and visualizing the full-stack performance trade-offs and interplay between HPC applications, MPI libraries, the communication fabric, and the file system is a challenging endeavor. Designing a holistic profiling and…

Graphics · Computer Science 2021-09-20 Pouya Kousha , Quentin Anthony , Hari Subramoni , Dhabaleswar K. Panda