Related papers: Axon Membrane Skeleton Structure is Optimized for …
Actin and spectrin are important constituents of axonal cytoskeleton. Periodic actin and spectrin structures are found in dendrites, initial segment of axon, and main axon. Actin and spectrin periodicity has been hypothesized to be…
The macroscopic properties, the properties of individual components and how those components interact with each other are three important aspects of a composited structure. An understanding of the interplay between them is essential in the…
In this paper, we analyze the effect of the redistribution of the transmembrane ion channels in the axon caused by longitudinal acoustic vibrations of the membrane. These oscillations can be excited by an external source of ultrasound and…
While the ultrastructure of the myelin has been considered to be a quasi-crystalline stable system, nowadays its multiscale complex dynamics appears to play a key role for its functionality, degeneration and repair processes following…
Axons functionally link the somato-dendritic compartment to synaptic terminals. Structurally and functionally diverse, they accomplish a central role in determining the delays and reliability with which neuronal ensembles communicate. By…
Active force generation by actin-myosin cortex coupled to the cell membrane allows the cell to deform, respond to the environment, and mediate cell motility and division. Several membrane-bound activator proteins move along it and couple to…
Here a viable and never before investigated mechanism of propagation of spikes along neurons is proposed. In the following, velocity of propagation of small-amplitude pressure waves through the cytoplasmic interior of myelinated and…
The organization of the axonal cytoskeleton is a key determinant of the normal function of an axon, which is a long thin projection away from a neuron. Under normal conditions two axonal cytoskeletal polymers microtubules and neurofilaments…
The saltatory propagation of action potentials on myelinated axons is conventionally explained by the mechanism employing local circuit ionic current flows between nodes of Ranvier. Under this framework, the myelin sheath with up to 100…
The myelinated axons are widely present in both central and peripheral nervous systems. Its unique compact spiraling structure poses significant challenges to understanding its biological functions and developmental mechanisms.…
This work proposes a two-dimensional electrophysiological model for describing neuronal responses to external electric stimuli under patch-clamped conditions. Our proposed model successfully captures the key features of the Hodgkin-Huxley…
Despite significant advances in understanding neuronal development, a fully quantitative framework that integrates intracellular mechanisms with environmental cues during axonal growth remains incomplete. Here, we present a unified…
The dynamics of a membrane coupled to an active fluid on top of a substrate is considered theoretically. It is assumed that the director field of the active fluid has rotational symmetry in the membrane plane. This situation is likely to be…
High-resolution structural information on membrane proteins is essential for understanding cell biology and for structure-based design of new medical drugs and drug delivery strategies. X-ray diffraction (XRD) can provide {\AA}ngstrom-level…
We present a general dynamical theory of a membrane coupled to an actin cortex containing polymerizing filaments with active stresses and currents, and demonstrate that active membrane dynamics [Phys. Rev. Lett \textbf{84}, 3494 (2000)] and…
The cytoskeleton is a model active matter system that controls diverse cellular processes from division to motility. While both active actomyosin dynamics and actin-microtubule interactions are key to the cytoskeleton's versatility and…
Intracellular transport is vital for the proper functioning and survival of a cell. Cargo (proteins, vesicles, organelles, etc.) is transferred from its place of creation to its target locations via molecular motor assisted transport along…
A broad range of membrane proteins display anomalous diffusion on the cell surface. Different methods provide evidence for obstructed subdiffusion and diffusion on a fractal space, but the underlying structure inducing anomalous diffusion…
Magnetic skyrmions exhibit unique, technologically relevant pseudo-particle behaviors which arise from their topological protection, including well-defined, three-dimensional dynamic modes that occur at microwave frequencies. During dynamic…
The actin cortex of an animal cell is a thin polymeric layer attached to the inner side of the plasma membrane. It plays a key role in shape regulation and pattern formation on the cellular and tissue scale and, in particular, generates the…