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Mathematical models of a cellular action potential in cardiac modelling have become increasingly complex, particularly in gating kinetics which control the opening and closing of individual ion channel currents. As cardiac models advance…

Quantitative Methods · Quantitative Biology 2021-04-28 C. Houston , B. Marchand , L. Engelbert , C. D. Cantwell

ABACUS (Atomic-orbital Based Ab-initio Computation at USTC) is an open-source software for first-principles electronic structure calculations and molecular dynamics simulations. It mainly features density functional theory (DFT) and…

Cardiovascular diseases are major causes of mortality globally. They often co-occur and are interrelated, leading to partial-order relationships among their onset times. However, these onset times are subject to informative censoring due to…

Methodology · Statistics 2026-04-07 Tonghui Yu , Liming Xiang

Numerous algorithms have been proposed for detecting anomalies (outliers, novelties) in an unsupervised manner. Unfortunately, it is not trivial, in general, to understand why a given sample (record) is labelled as an anomaly and thus…

Machine Learning · Computer Science 2021-10-19 Nikolaos Myrtakis , Ioannis Tsamardinos , Vassilis Christophides

Statistical shape modeling (SSM) is a valuable and powerful tool to generate a detailed representation of complex anatomy that enables quantitative analysis and the comparison of shapes and their variations. SSM applies mathematics,…

Image and Video Processing · Electrical Eng. & Systems 2022-09-14 Krithika Iyer , Alan Morris , Brian Zenger , Karthik Karanth , Benjamin A Orkild , Oleksandre Korshak , Shireen Elhabian

Purpose- Coarctation of the Aorta (CoA) patient-specific computational fluid dynamics (CFD) studies in resource constrained settings are limited by the available imaging modalities for geometry and velocity data acquisition. Doppler…

Computational Engineering, Finance, and Science · Computer Science 2025-06-04 Vincent Milimo Masilokwa Punabantu , Malebogo Ngoepe , Amit Kumar Mishra , Thomas Aldersley , John Lawrenson , Liesl Zuhlke

Acquiring annotated data at scale with rare diseases or conditions remains a challenge. It would be extremely useful to have a method that controllably synthesizes images that can correct such underrepresentation. Assuming a proper latent…

Image and Video Processing · Electrical Eng. & Systems 2021-07-06 Spyridon Thermos , Xiao Liu , Alison O'Neil , Sotirios A. Tsaftaris

Accurate estimation of shape thickness from medical images is crucial in clinical applications. For example, the thickness of myocardium is one of the key to cardiac disease diagnosis. While mathematical models are available to obtain…

Image and Video Processing · Electrical Eng. & Systems 2020-08-26 Qiaoying Huang , Eric Z. Chen , Hanchao Yu , Yimo Guo , Terrence Chen , Dimitris Metaxas , Shanhui Sun

MOTIVATION: Left ventricular (LV) hypertrophy is a strong predictor of cardiovascular outcomes, but its genetic regulation remains largely unexplained. Conventional phenotyping relies on manual calculation of LV mass and wall thickness, but…

Foundation models have achieved remarkable success across various domains, yet their adoption in healthcare remains limited. While significant advances have been made in medical imaging, genetic biomarkers, and time series from electronic…

Mathematical models and numerical simulations offer a non-invasive way to explore cardiovascular phenomena, providing access to quantities that cannot be measured directly. In this study, we start with a one-dimensional multiscale blood…

Machine Learning · Computer Science 2026-04-09 Giulia Bertaglia , Raffaella Fiamma Cabini

Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, underscoring the need for reliable and efficient predictive tools that support early intervention. Traditional diagnostic approaches rely on handcrafted features…

Machine Learning · Computer Science 2025-12-17 Tejaswani Dash , Gautam Datla , Anudeep Vurity , Tazeem Ahmad , Mohd Adnan , Saima Rafi , Saisha Patro , Saina Patro

Heart murmurs are a common manifestation of cardiovascular diseases and can provide crucial clues to early cardiac abnormalities. While most current research methods primarily focus on the accuracy of models, they often overlook other…

Sound · Computer Science 2024-05-08 Zixing Zhang , Tao Pang , Jing Han , Björn W. Schuller

A cardiac digital twin is a virtual replica of a patient-specific heart, mimicking its anatomy and physiology. A crucial step of building a cardiac digital twin is anatomical twinning, where the computational mesh of the digital twin is…

Cardiovascular disease remains a leading global cause of mortality, necessitating accurate risk prediction tools. Traditional methods, such as QRISK and the Framingham heart score, exhibit limitations in their ability to incorporate…

Genomics · Quantitative Biology 2024-02-12 Farnoush Shishehbori , Zainab Awan

Cardiovascular diseases (CVDs) are the leading causes of mortality worldwide. The contraction and relaxation of left ventricle (LV) is the main driving force of blood circulation. Altered LV hemodynamics is believed to be associated with…

Medical Physics · Physics 2019-11-04 Fanwei Kong , Christoph Augustin , Kevin Sack , Shawn Shadden

This study presents a new strategy for the identification of material parameters in the case of restricted or redundant data, based on a hybrid approach combining a genetic algorithm and the Levenberg-Marquardt method. The proposed…

Neural and Evolutionary Computing · Computer Science 2017-07-05 S. Carbillet , V. Guicheret-Retel , F. Trivaudey , F. Richard , M. L. Boubakar

Simulating the cardiac function requires the numerical solution of multi-physics and multi-scale mathematical models. This underscores the need for streamlined, accurate, and high-performance computational tools. Despite the dedicated…

The prime purpose of this project is to develop a portable cardiac abnormality monitoring device which can drastically improvise the quality of the monitoring and the overall safety of the device. While a generic, low cost, wearable battery…

Neural and Evolutionary Computing · Computer Science 2023-04-18 Prof Sangeetha R G , Kishore Anand K , Sreevatsan B , Vishal Kumar A

Electrical analogy (Lumped method) is an easy way to model human cardiovascular system. In this paper Lumped method is used for simulating a complete model. It describes a 36-vessel model and cardiac system of human body with details that…

Medical Physics · Physics 2014-11-21 Omid Ghasemalizadeh , Mohammad Reza Mirzaee , Bahar Firoozabadi , Kamran Hassani