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Disease mapping analyses the distribution of several disease outcomes within a territory. Primary goals include identifying areas with unexpected changes in mortality rates, studying the relation among multiple diseases, and dividing the…

Methodology · Statistics 2025-08-19 Andrea Sottosanti , Enrico Bovo , Pietro Belloni , Giovanna Boccuzzo

Background: Opioid misuse is a major public health issue in the United States and in particular Ohio. However, the burden of the epidemic is challenging to quantify as public health surveillance measures capture different aspects of the…

Applications · Statistics 2018-06-15 Staci Hepler , Erin McKnight , Andrea Bonny , David Kline

We examine US County-level observational data on Lung Cancer mortality rates in 2012 and overall Circulatory Respiratory mortality rates in 2016 as well as their "Top Ten" potential causes from Federal or State sources. We find that these…

Applications · Statistics 2023-05-17 Robert L. Obenchain , S. Stanley Young

The surprisingly mercurial Covid-19 pandemic has highlighted the need to not only accelerate research on infectious disease, but to also study them using novel techniques and perspectives. A major contributor to the difficulty of containing…

Populations and Evolution · Quantitative Biology 2022-07-21 Aminur Rahman , Angela Peace , Ramesh Kesawan , Souparno Ghosh

In usual demographic analysis, force of mortality is a function of one variable, that is, of age. In this article bi-variate and multivariate force of mortality functions are introduced for the first time to explain mortality differentials.…

Dynamical Systems · Mathematics 2019-02-26 Swagata Mitra , Pratyush Singh , Arni S. R. Srinivasa Rao

Urban scaling theory posits that urban indicators follow power-law relations with population, yet the evolution of these patterns - and the role of regional differences in settings marked by social inequalities and unplanned urbanization -…

Aging is a multidimensional process where phenotypes change at varying rates. Longitudinal studies of aging typically involve following a cohort of individuals over the course of several years. This design is hindered by cost, attrition,…

Multivariate spatial disease mapping has become a pivotal part of everyday practice in social epidemiology. Despite the existence of several specifications for the relation between different outcomes, there is still a need for a new…

Applications · Statistics 2024-10-30 P. Escobar-Hernández , A. López-Quílez , F. Palmí-Perales , M. Marco

We study the dynamics of cause--specific mortality rates among countries by considering them as compositions of functions. We develop a novel framework for such data structure, with particular attention to functional PCA. The application of…

Methodology · Statistics 2020-08-03 Marco Stefanucci , Stefano Mazzuco

Time-to-event models are commonly used to study associations between risk factors and disease outcomes in the setting of electronic health records (EHR). In recent years, focus has intensified on social determinants of health, highlighting…

Applications · Statistics 2025-11-26 Yueming Shen , Christian Pean , David Dunson , Samuel Berchuck

Participants: This study employed a combination of Vector Autoregression (VAR) model and Graph Neural Networks (GNN) to systematically construct dynamic causal inference. Multiple classic classification algorithms were compared, including…

Quantitative Methods · Quantitative Biology 2025-03-20 Qizhi Zheng , Ayang Zhao , Xinzhu Wang , Yanhong Bai , Zikun Wang , Xiuying Wang , Xianzhang Zeng , Guanghui Dong

Identifying and utilising various biomarkers for tracking Alzheimer's disease (AD) progression have received many recent attentions and enable helping clinicians make the prompt decisions. Traditional progression models focus on extracting…

Machine Learning · Computer Science 2023-11-08 Xulong Wang , Yu Zhang , Menghui Zhou , Tong Liu , Jun Qi , Po Yang

There has been growing interest on forecasting mortality. In this article, we propose a novel dynamic Bayesian approach for modeling and forecasting the age-at-death distribution, focusing on a three-components mixture of a Dirac mass, a…

Applications · Statistics 2021-12-20 Emanuele Aliverti , Stefano Mazzuco , Bruno Scarpa

Stroke remains a leading cause of global morbidity and mortality, imposing a heavy socioeconomic burden. Advances in endovascular reperfusion therapy and CT and MR imaging for treatment guidance have significantly improved patient outcomes.…

When modeling sub-national mortality rates, it is important to incorporate any possible correlation among sub-populations to improve forecast accuracy. Moreover, forecasts at the sub-national level should aggregate consistently across the…

Applications · Statistics 2020-11-17 Han Lin Shang , Yang Yang

Fitting spatio-temporal models for areal data is crucial in many fields such as cancer epidemiology. However, when data sets are very large, many issues arise. The main objective of this paper is to propose a general procedure to analyze…

Methodology · Statistics 2023-02-06 E. Orozco-Acosta , A. Adin , M. D. Ugarte

We introduce a method called neighbor-based bootstrapping (NB2) that can be used to quantify the geospatial variation of a variable. We applied this method to an analysis of the incidence rates of disease from electronic medical record data…

Methodology · Statistics 2017-03-07 Maria T Patterson , Robert L Grossman

Many spatio-temporal data record the time of birth and death of individuals, along with their spatial trajectories during their lifetime, whether through continuous-time observations or discrete-time observations. Natural applications…

Probability · Mathematics 2021-07-14 Frédéric Lavancier , Ronan Le Guével

The opioid crisis remains one of the most daunting and complex public health problems in the United States. This study investigates the national epidemic by analyzing vulnerability profiles of three key factors: opioid-related mortality…

We investigate joint modeling of longevity trends using the spatial statistical framework of Gaussian Process regression. Our analysis is motivated by the Human Mortality Database (HMD) that provides unified raw mortality tables for nearly…

Applications · Statistics 2020-03-06 Nhan Huynh , Mike Ludkovski
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