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Reliable predictions from systems biology models require knowing whether parameters can be estimated from available data, and with what certainty. Identifiability analysis reveals whether parameters are learnable in principle (structural…

Differential equation models are crucial to scientific processes. The values of model parameters are important for analyzing the behaviour of solutions. A parameter is called globally identifiable if its value can be uniquely determined…

Quantitative Methods · Quantitative Biology 2024-02-07 Helen Byrne , Heather Harrington , Alexey Ovchinnikov , Gleb Pogudin , Hamid Rahkooy , Pedro Soto

Identifiability of parameters is an essential property for a statistical model to be useful in most settings. However, establishing parameter identifiability for Bayesian networks with hidden variables remains challenging. In the context of…

Statistics Theory · Mathematics 2014-06-04 Elizabeth S. Allman , John A. Rhodes , Elena Stanghellini , Marco Valtorta

Data-driven modeling of dynamical systems often faces numerous data-related challenges. A fundamental requirement is the existence of a unique set of parameters for a chosen model structure, an issue commonly referred to as identifiability.…

Systems and Control · Electrical Eng. & Systems 2024-05-24 Arthur N. Montanari , François Lamoline , Robert Bereza , Jorge Gonçalves

This paper presents a method for investigating, through an automatic procedure, the (lack of) identifiability of parametrized dynamical models. This method takes into account constraints on parameters and returns parameters whose…

Dynamical Systems · Mathematics 2016-10-11 Nathalie Verdière , Sébastien Orange

Parameter identifiability is often requisite to the effective application of mathematical models in the interpretation of biological data, however theory applicable to the study of partial differential equations remains limited. We present…

Analysis of PDEs · Mathematics 2025-04-08 Yurij Salmaniw , Alexander P Browning

Parameter identifiability describes whether, for a given differential model, one can determine parameter values from model equations. Knowing global or local identifiability properties allows construction of better practical experiments to…

Mathematical Software · Computer Science 2021-07-02 Ilia Ilmer , Alexey Ovchinnikov , Gleb Pogudin

Structural identifiability is an important property of parametric ODE models. When conducting an experiment and inferring the parameter value from the time-series data, we want to know if the value is globally, locally, or non-identifiable.…

Discrete Mathematics · Computer Science 2024-06-25 Natali Gogishvili

While hidden class models of various types arise in many statistical applications, it is often difficult to establish the identifiability of their parameters. Focusing on models in which there is some structure of independence of some of…

Statistics Theory · Mathematics 2009-09-01 Elizabeth S. Allman , Catherine Matias , John A. Rhodes

Structural global parameter identifiability indicates whether one can determine a parameter's value from given inputs and outputs in the absence of noise. If a given model has parameters for which there may be infinitely many values, such…

Symbolic Computation · Computer Science 2022-04-05 Ilia Ilmer , Alexey Ovchinnikov , Gleb Pogudin , Pedro Soto

Stochasticity plays a key role in many biological systems, necessitating the calibration of stochastic mathematical models to interpret associated data. For model parameters to be estimated reliably, it is typically the case that they must…

Interpreting data with mathematical models is an important aspect of real-world industrial and applied mathematical modeling. Often we are interested to understand the extent to which a particular set of data informs and constrains model…

Methodology · Statistics 2025-03-06 Matthew J Simpson , Ruth E Baker

Structural parameter identifiability is a property of a differential model with parameters that allows for the parameters to be determined from the model equations in the absence of noise. One of the standard approaches to assessing this…

Algebraic Geometry · Mathematics 2020-12-29 Alexey Ovchinnikov , Gleb Pogudin , Peter Thompson

Elimination of unknowns in a system of differential equations is often required when analysing (possibly nonlinear) dynamical systems models, where only a subset of variables are observable. One such analysis, identifiability, often relies…

Algebraic Geometry · Mathematics 2022-11-28 Ruiwen Dong , Christian Goodbrake , Heather A Harrington , Gleb Pogudin

Identifiability is a necessary condition for successful parameter estimation of dynamic system models. A major component of identifiability analysis is determining the identifiable parameter combinations, the functional forms for the…

Quantitative Methods · Quantitative Biology 2013-10-07 Marisa C. Eisenberg , Michael A. L. Hayashi

Agent-Based Models (ABM) are computational scenario-generators, which can be used to predict the possible future outcomes of the complex system they represent. To better understand the robustness of these predictions, it is necessary to…

General Economics · Economics 2022-08-08 Karl Naumann-Woleske , Max Sina Knicker , Michael Benzaquen , Jean-Philippe Bouchaud

We developed a novel approach to identification and model testing in linear structural equation models (SEMs) based on auxiliary variables (AVs), which generalizes a widely-used family of methods known as instrumental variables. The…

Methodology · Statistics 2019-10-09 Bryant Chen , Daniel Kumor , Elias Bareinboim

Learning the unknown causal parameters of a linear structural causal model is a fundamental task in causal analysis. The task, known as the problem of identification, asks to estimate the parameters of the model from a combination of…

Artificial Intelligence · Computer Science 2024-07-18 Julian Dörfler , Benito van der Zander , Markus Bläser , Maciej Liskiewicz

Computational and mathematical models rely heavily on estimated parameter values for model development. Identifiability analysis determines how well the parameters of a model can be estimated from experimental data. Identifiability analysis…

Quantitative Methods · Quantitative Biology 2021-02-12 Marissa Renardy , Denise Kirschner , Marisa Eisenberg

A key step in mechanistic modelling of dynamical systems is to conduct a structural identifiability analysis. This entails deducing which parameter combinations can be estimated from a given set of observed outputs. The standard…

Optimization and Control · Mathematics 2026-03-30 Johannes G Borgqvist , Alexander P Browning , Fredrik Ohlsson , Ruth E Baker
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