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Mediation analytics help examine if and how an intermediate variable mediates the influence of an exposure variable on an outcome of interest. Quantiles, rather than the mean, of an outcome are scientifically relevant to the comparison…

Methodology · Statistics 2024-12-23 Canyi Chen , Yinqiu He , Huixia J. Wang , Gongjun Xu , Peter X. -K. Song

Mediation analysis has traditionally focused on outcome-level summary contrasts, such as mean effects, which may obscure substantial distributional changes induced by complex and nonlinear causal mechanisms. We propose Distributional Causal…

Machine Learning · Statistics 2026-05-05 Jinlun Zhang , Haoneng Huang , Zishu Zhan , Chunquan Ou

E-commerce companies have a number of online products, such as organic search, sponsored search, and recommendation modules, to fulfill customer needs. Although each of these products provides a unique opportunity for users to interact with…

Applications · Statistics 2020-06-23 Xuan Yin , Liangjie Hong

Mediation analysis is becoming an increasingly important tool in scientific studies. A central question in high-dimensional mediation analysis is to infer the significance of individual mediators. The main challenge is the sheer number of…

Methodology · Statistics 2021-02-23 Chengchun Shi , Lexin Li

We study causal effect estimation from a mixture of observational and interventional data in a confounded linear regression model with multivariate treatments. We show that the statistical efficiency in terms of expected squared error can…

Online experimentation is at the core of Booking.com's customer-centric product development. While randomised controlled trials are a powerful tool for estimating the overall effects of product changes on business metrics, they often fall…

Human-Computer Interaction · Computer Science 2018-10-31 Bahattin Tolga Öztan , Zoé van Havre , Caio Gomes , Lukas Vermeer

We consider assessing causal mediation in the presence of a post-treatment event (examples include noncompliance, a clinical event, or death). We identify natural mediation effects for the entire study population and for each principal…

Methodology · Statistics 2024-09-13 Chao Cheng , Fan Li

Mediation analysis plays a crucial role in causal inference as it can investigate the pathways through which treatment influences outcome. Most existing mediation analysis assumes that mediation effects are static and homogeneous within…

Methodology · Statistics 2026-03-02 Yijiao Zhang , Yubai Yuan , Yuexia Zhang , Zhongyi Zhu , Annie Qu

Questions concerning mediated causal effects are of great interest in psychology, cognitive science, medicine, social science, public health, and many other disciplines. For instance, about 60% of recent papers published in leading journals…

Statistics Theory · Mathematics 2013-03-05 Ilya Shpitser

Many research questions concern treatment effects on outcomes that can recur several times in the same individual. For example, medical researchers are interested in treatment effects on hospitalizations in heart failure patients and sports…

Methodology · Statistics 2024-12-31 Matias Janvin , Jessica G. Young , Pål C. Ryalen , Mats J. Stensrud

In the absence of randomized controlled and natural experiments, it is necessary to balance the distributions of (observable) covariates of the treated and control groups in order to obtain an unbiased estimate of a causal effect of…

Methodology · Statistics 2022-03-02 Martin Cousineau , Vedat Verter , Susan A. Murphy , Joelle Pineau

To estimate direct and indirect effects of an exposure on an outcome from observed data strong assumptions about unconfoundedness are required. Since these assumptions cannot be tested using the observed data, a mediation analysis should…

Statistics Theory · Mathematics 2018-03-29 Anita Lindmark , Xavier de Luna , Marie Eriksson

Common methods for interpreting neural models in natural language processing typically examine either their structure or their behavior, but not both. We propose a methodology grounded in the theory of causal mediation analysis for…

Computation and Language · Computer Science 2020-11-24 Jesse Vig , Sebastian Gehrmann , Yonatan Belinkov , Sharon Qian , Daniel Nevo , Simas Sakenis , Jason Huang , Yaron Singer , Stuart Shieber

Biological sequencing data consist of read counts, e.g. of specified taxa and often exhibit sparsity (zero-count inflation) and overdispersion (extra-Poisson variability). As most sequencing techniques provide an arbitrary total count,…

Applications · Statistics 2024-07-01 Noora Kartiosuo , Jaakko Nevalainen , Olli Raitakari , Katja Pahkala , Kari Auranen

Causal mediation analysis is widely utilized to separate the causal effect of treatment into its direct effect on the outcome and its indirect effect through an intermediate variable (the mediator). In this study we introduce a functional…

Applications · Statistics 2018-05-21 Yi Zhao , Xi Luo , Martin Lindquist , Brian Caffo

The most widely discussed methods for estimating the Average Causal Effect/Average Treatment Effect are those for intervention in discrete binary variables whose value represents intervention/non-intervention groups. On the other hand,…

Machine Learning · Statistics 2022-03-21 Yoshiaki Kitazawa

Identification of standard mediated effects such as the natural indirect effect relies on heavy causal assumptions. By circumventing such assumptions, so-called randomized interventional indirect effects have gained popularity in the…

Methodology · Statistics 2023-10-03 Caleb H. Miles

We demonstrate a comprehensive semiparametric approach to causal mediation analysis, addressing the complexities inherent in settings with longitudinal and continuous treatments, confounders, and mediators. Our methodology utilizes a…

With reference to a single mediator context, this brief report presents a model-based strategy to estimate counterfactual direct and indirect effects when the response variable is ordinal and the mediator is binary. Postulating a logistic…

Methodology · Statistics 2022-10-25 Elena Stanghellini , Maria Kateri

Simulation methods are among the most ubiquitous methodological tools in statistical science. In particular, statisticians often is simulation to explore properties of statistical functionals in models for which developed statistical theory…

Methodology · Statistics 2023-08-22 Tyrel Stokes , Ian Shrier , Russell Steele
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