Related papers: Three-dimensional flow in Kupffer's Vesicle
Fluid mechanics plays a vital role in early vertebrate embryo development, an example being the establishment of left-right asymmetry. Following the dorsal-ventral and anterior-posterior axes, the left-right axis is the last to be…
In embryonic development, programmed cell shape changes are essential for building functional organs, but in many cases the mechanisms that precisely regulate these changes remain unknown. We propose that fluid-like drag forces generated by…
Left-right symmetry breaking is critical to vertebrate embryonic development; in many species this process begins with cilia-driven flow in a structure termed the `node'. Primary `whirling' cilia, tilted towards the posterior, transport…
Cells or bacteria carrying cilia on their surface show many striking features : alignment of cilia in an array, two-phase asymmetric beating for each cilium, coordination between cilia and existence of metachronal waves with a constant…
The concept of internal anatomical asymmetry is familiar; usually in humans the heart is on the left and the liver is on the right, however how does the developing embryo know to produce this consistent laterality? Symmetry breaking…
Cilia and flagella are actively bending slender organelles, performing functions such as motility, feeding and embryonic symmetry breaking. We review the mechanics of viscous-dominated microscale flow, including time-reversal symmetry, drag…
The dynamic flow of cerebrospinal fluid (CSF) in brain ventricles exhibits flow features on several scales, both spatially and temporally. Most analysis of this complex flow and the accompanying transport has used instantaneous (Eulerian)…
The proposed flow in a 3-D cubic cavity is driven by its parallel walls moving in perpendicular directions to create a genuinely three-dimensional highly separated vortical flow yet having simple single-block cubical geometry of…
In this paper, we showcase how flow obstruction by a deformable object can lead to symmetry breaking in curved domains subject to angular acceleration. Our analysis is motivated by the deflection of the cupula, a soft tissue located in the…
The laboratory models of the human heart left ventricle developed in the last decades gave a valuable contribution to the comprehension of the role of the fluid dynamics in the cardiac function and to support the interpretation of the data…
In the present paper, we examine the viscous flow evolution in a square cavity. Coupled with the stream function, the initial-boundary value problem of the vorticity is numerically solved by a method of iteration. The only boundary…
Motile cilia beat in an asymmetric fashion in order to propel the surrounding fluid. When many cilia are located on a surface, their beating can synchronise such that their phases form metachronal waves. Here, we computationally study a…
To gain insight into the nature of biological synchronization at the microscopic scale, we here investigate the hydrodynamic synchronization between conically rotating objects termed nodal cilia. A mechanical model of three rotating cilia…
The study numerically investigates the three-dimensionality in the flow and two-degree-of-freedom (2 DOF) vortex-induced-vibrations (VIV) characteristics of an elastically mounted circular cylinder. The cylinder is allowed to vibrate in…
We calculate the hydrodynamic flow field generated far from a cilium which is attached to a surface and beats periodically. In the case of two beating cilia, hydrodynamic interactions can lead to synchronization of the cilia, which are…
We use numerical simulations to systematically investigate the vesicle dynamics in two-dimensional (2D) Taylor-Green vortex flow in the absence of inertial forces. Vesicles are highly deformable membranes encapsulating an incompressible…
During embryonic development in vertebrates, left-right (L/R) asymmetry is reliably generated by a conserved mechanism: a L/R asymmetric signal is transmitted from the embryonic node to other parts of the embryo by the L/R asymmetric…
We introduce a model system of stochastic entities, called 'rowers' which include some essentialities of the behavior of real cilia. We introduce and discuss the problem of symmetry breaking for these objects and its connection with the…
In this work, the coupled dynamics of the gap flow and the vortex-induced vibration (VIV) on a side-by-side (SBS) arrangement of two circular cylinders is numerically investigated at moderate Reynolds number 100 < Re < 800. Of particular…
Clockwise rotational movement of isolated single cilia in mice embryo was investigated in vivo. The movement generates leftward fluid flow in the node cavity and plays an important role in left-right determination. The leftward…