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The fate of scientific hypotheses often relies on the ability of a computational model to explain the data, quantified in modern statistical approaches by the likelihood function. The log-likelihood is the key element for parameter…

Machine Learning · Computer Science 2021-01-27 Bas van Opheusden , Luigi Acerbi , Wei Ji Ma

We introduce the Hawkes process with renewal immigration and make its statistical estimation possible with two Expectation Maximization (EM) algorithms. The standard Hawkes process introduces immigrant points via a Poisson process, and each…

Applications · Statistics 2014-07-29 Spencer Wheatley , Vladimir Filimonov , Didier Sornette

The stationary sampling distribution of a neutral decoupled Moran or Wright-Fisher diffusion with neutral mutations is known to first order for a general rate matrix with small but otherwise unconstrained mutation rates. Using this…

Populations and Evolution · Quantitative Biology 2020-05-07 Claus Vogl , Lynette C. Mikula , Conrad J. Burden

The use of standard statistical methods, such as maximum likelihood, is often justified based on their asymptotic properties. For suitably regular models, this theory is standard but, when the model is non-regular, e.g., the support depends…

Methodology · Statistics 2016-08-25 Ryan Martin , Yi Lin

Heterogeneity is a dominant factor in the behaviour of many biological processes. Despite this, it is common for mathematical and statistical analyses to ignore biological heterogeneity as a source of variability in experimental data.…

Bayesian inference for models with intractable likelihood functions represents a challenging suite of problems in modern statistics. In this work we analyse the Conway-Maxwell-Poisson (COM-Poisson) distribution, a two parameter…

Computation · Statistics 2020-07-13 Alan Benson , Nial Friel

Integrated population models (IPMs) combine multiple ecological data types such as capture-mark-recapture histories, reproduction surveys, and population counts into a single statistical framework. In such models, each data type is…

Populations and Evolution · Quantitative Biology 2024-11-05 Frédéric Barraquand

Given a social network $G$ and an integer $k$, the influence maximization (IM) problem asks for a seed set $S$ of $k$ nodes from $G$ to maximize the expected number of nodes influenced via a propagation model. The majority of the existing…

Social and Information Networks · Computer Science 2020-04-15 Keke Huang , Jing Tang , Kai Han , Xiaokui Xiao , Wei Chen , Aixin Sun , Xueyan Tang , Andrew Lim

Distance-based approaches in phylogenetics such as Neighbor-Joining are a fast and popular approach for building trees. These methods take pairs of sequences from them construct a value that, in expectation, is additive under a stochastic…

Populations and Evolution · Quantitative Biology 2008-08-21 Mike Steel

This paper provides a unified perspective for the Kullback-Leibler (KL)-divergence and the integral probability metrics (IPMs) from the perspective of maximum likelihood density-ratio estimation (DRE). Both the KL-divergence and the IPMs…

Machine Learning · Computer Science 2022-02-01 Masahiro Kato , Masaaki Imaizumi , Kentaro Minami

Generalized linear mixed models are useful in studying hierarchical data with possibly non-Gaussian responses. However, the intractability of likelihood functions poses challenges for estimation. We develop a new method suitable for this…

Methodology · Statistics 2022-01-26 Zexi Song , Zhiqiang Tan

Cosmological hydrodynamic simulations can accurately predict the properties of the intergalactic medium (IGM), but only under the condition of retaining high spatial resolution necessary to resolve density fluctuations in the IGM. This…

Cosmology and Nongalactic Astrophysics · Physics 2016-08-17 Daniele Sorini , José Oñorbe , Zarija Lukić , Joseph F. Hennawi

Finding a transformation between two unknown probability distributions from finite samples is crucial for modeling complex data distributions and performing tasks such as sample generation, domain adaptation and statistical inference. One…

Machine Learning · Computer Science 2024-07-11 Zhe Xiong , Qiaoqiao Ding , Xiaoqun Zhang

Modelling in biology must adapt to increasingly complex and massive data. The efficiency of the inference algorithms used to estimate model parameters is therefore questioned. Many of these are based on stochastic optimization processes…

Indirect Inference (I-I) is a popular technique for estimating complex parametric models whose likelihood function is intractable, however, the statistical efficiency of I-I estimation is questionable. While the efficient method of moments,…

Econometrics · Economics 2020-06-19 Veronika Czellar , David T. Frazier , Eric Renault

Modern data sets in various domains often include units that were sampled non-randomly from the population and have a latent correlation structure. Here we investigate a common form of this setting, where every unit is associated with a…

Methodology · Statistics 2019-07-25 Omer Weissbrod , Shachar Kaufman , David Golan , Saharon Rosset

By building upon the recent theory that established the connection between implicit generative modeling (IGM) and optimal transport, in this study, we propose a novel parameter-free algorithm for learning the underlying distributions of…

Machine Learning · Statistics 2019-06-12 Antoine Liutkus , Umut Şimşekli , Szymon Majewski , Alain Durmus , Fabian-Robert Stöter

Pathogen genome data offers valuable structure for spatial models, but its utility is limited by incomplete sequencing coverage. We propose a probabilistic framework for inferring genetic distances between unsequenced cases and known…

Genomics · Quantitative Biology 2025-09-10 Haley Stone , Jing Du , Hao Xue , Matthew Scotch , David Heslop , Andreas Züfle , Chandini Raina MacIntyre , Flora Salim

Predicting competitive outcomes typically requires fitting dynamical models to data, from which interaction strengths and coexistence indicators such as invasion criteria can be produced. Methods that allow to propagate parameter…

Populations and Evolution · Quantitative Biology 2025-04-10 Matthieu Paquet , Frédéric Barraquand

Inhomogeneous phase-type (IPH) distributions extend classical phase-type models by allowing transition intensities to vary over time, offering greater flexibility for modeling heavy-tailed or time-dependent absorption phenomena. We focus on…

Methodology · Statistics 2025-12-19 Fernando Baltazar-Larios , Alejandra Quintos