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We analyse mathematical models in order to understand how microstructural features of vascular networks may affect blood-flow dynamics, and to identify particular characteristics that promote the onset of self-sustained oscillations. By…

Quantitative Methods · Quantitative Biology 2022-06-23 Yaron Ben-Ami , George W. Atkinson , Joe M. Pitt-Francis , Philip K. Maini , Helen M. Byrne

The reversible aggregation of red blood cells (RBCs) is a process of erythrocytes clumping that strongly influences the rheological properties of blood. The adhesion of RBCs has been studied extensively in the frame of cell-to-cell…

Biological Physics · Physics 2017-10-09 Alexey Popov , Tatiana Avsievich , Alexander Bykov , Igor Meglinski

Inertial focusing in curved microfluidic ducts exploits the interaction of drag force from the Dean flow with the inertial lift force to separate particles or cells laterally across the cross-section width according to their size.…

Fluid Dynamics · Physics 2023-10-31 Brendan Harding , Yvonne M. Stokes , Rahil N. Valani

Background and Objective: This proof of concept study investigates mathematical modelling of blood flow and oxygen transport in cerebral microcirculation, focusing on understanding hemodynamic responses. By coupling oxygen transport models…

Numerical Analysis · Mathematics 2024-11-19 Maryam Samavaki , Santtu Söderholm , Arash Zarrin Nia , Sampsa Pursiainen

Diffusion within porous media, such as biological tissues, exhibits departures from conventional Fick's laws, which could result in space-fractional diffusion. The paper considers a reaction-diffusion system with two spatial compartments --…

General Mathematics · Mathematics 2025-11-12 Dimiter Prodanov

Background and Objective: The role of red blood cell dynamics is emphasised in certain cardiovascular diseases, and thus needs to be closely studied. A multiphase model of blood flow allows the resolution of locally varying density of red…

Fluid Dynamics · Physics 2021-10-07 Konstantinos G. Lyras , Jack Lee

Blood flow in sickle cell disease (SCD) can substantially differ from normal blood flow due to significant alterations in the physical properties of the red blood cells (RBCs). Chronic complications, such as inflammation of the endothelial…

Biological Physics · Physics 2020-05-13 Xiao Zhang , Christina Caruso , Wilbur A. Lam , Michael D. Graham

The transport of Brownian particles in a slit geometry in the presence of an arbitrary two-dimensional periodic energy landscape and driven by an external force or convected by a flow field is investigated by means of macrotransport theory.…

Statistical Mechanics · Physics 2012-10-16 Jorge A. Bernate , German Drazer

Many of the intriguing properties of blood originate from its cellular nature. Bulk effects, such as viscosity, depend on the local shear rates and on the size of the vessels. While empirical descriptions of bulk rheology are available for…

Computational Engineering, Finance, and Science · Computer Science 2023-05-05 Gabor Zavodszky , Christian Spieker , Benjamin Czaja , Britt van Rooij

We present a quantitative semiclassical treatment of the effects of bifurcations on the spectral rigidity and the spectral form factor of a Hamiltonian quantum system defined by two coupled quartic oscillators, which on the classical level…

Chaotic Dynamics · Physics 2016-08-16 Marta Gutiérrez , Matthias Brack , Klaus Richter , Ayumu Sugita

We analyze and simulate a two dimensional Brownian multi-type particle system with death and branching (birth) depending on the position of particles of different types. The system is confined in the two dimensional box, whose boundaries…

Condensed Matter · Physics 2009-10-28 K. Burdzy , Robert Holyst , D. Ingerman , P. March

The geometry of blood vessels strongly affects hemostasis and thrombosis through red blood cell (RBC) dynamics and platelet margination. Growing platelet aggregates, in turn, reshape the local vessel wall topography, leading to a strongly…

Fluid Dynamics · Physics 2026-04-08 Eleonora Pero , Giovanna Tomaiuolo , Stefano Guido , Claire Denham , Timm Krueger

Red blood cells (RBCs) sustain mechanical stresses associated with microcirculatory flow through ATP-driven plasma membrane flickering. This is an active phenomenon driven by motor proteins that regulate interactions between the spectrin…

The fluid dynamics video that is presented here outlines recent advances in the simulation of multiphase cellular blood flow through the direct numerical simulations of deformable red blood cells (RBCs) demonstrated through several…

Fluid Dynamics · Physics 2009-10-20 Jonathan R. Clausen , Daniel A. Reasor , Cyrus K. Aidun

We present a numerical analysis of the rheology of a suspension of red blood cells (RBCs) for different volume fractions in a wall-bounded, effectively inertialess, small amplitude oscillatory shear (SAOS) flow for a wide range of applied…

Fluid Dynamics · Physics 2024-04-08 Naoki Takeishi , Marco Edoardo Rosti , Naoto Yokoyama , Luca Brandt

The understanding and prediction of sudden changes in flow patterns is of paramount importance in the analysis of geophysical flows as these rare events relate to critical phenomena such as atmospheric blocking, the weakening of the Gulf…

Dynamical Systems · Mathematics 2020-01-07 Moussa Ndour , Kathrin Padberg-Gehle

Abnormal hemoglobins can have major consequences for tissue delivery of oxygen. Correct diagnosis of hemoglobinopathies with altered oxygen affinity requires a determination of hemoglobin oxygen dissociation curve (ODC), which relates the…

Biomolecules · Quantitative Biology 2020-01-03 Rosella Scrima , Sabino Fugetto , Nazzareno Capitanio , Domenico L. Gatti

Flow diversion has become a key treatment modality for selected intracranial aneurysms, relying on the principle that a dense mesh of stent wires disrupts blood flow into the aneurysm sac, promoting thrombosis and vessel reconstruction.…

We investigate the physics of an optically-driven micromotor of biological origin. A single, live red blood cell, when placed in an optical trap folds into a rod-like shape. If the trapping laser beam is circularly polarized, the folded RBC…

Biological Physics · Physics 2009-11-11 A. Ghosh , Supurna Sinha , J. A. Dharmadhikari , S. Roy , A. K. Dharmadhikari , J. Samuel , S. Sharma , D. Mathur

We discuss numerically the non-perturbative effects in exponential random graphs which are analogue of eigenvalue instantons in matrix models. The phase structure of exponential random graphs with chemical potential for 4-cycles and degree…

High Energy Physics - Theory · Physics 2021-05-19 Alexander Gorsky , Olga Valba
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