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This paper presents a framework to tackle constrained combinatorial optimization problems using deep Reinforcement Learning (RL). To this end, we extend the Neural Combinatorial Optimization (NCO) theory in order to deal with constraints in…

Machine Learning · Computer Science 2020-06-23 Ruben Solozabal , Josu Ceberio , Martin Takáč

Proximal Policy Optimization (PPO) is a popular deep policy gradient algorithm. In standard implementations, PPO regularizes policy updates with clipped probability ratios, and parameterizes policies with either continuous Gaussian…

Machine Learning · Computer Science 2020-09-24 Chloe Ching-Yun Hsu , Celestine Mendler-Dünner , Moritz Hardt

We present a proximal policy optimization (PPO) agent trained through curriculum learning (CL) principles and meticulous reward engineering to optimize a real-world high-throughput waste sorting facility. Our work addresses the challenge of…

Machine Learning · Computer Science 2024-07-24 Abhijeet Pendyala , Asma Atamna , Tobias Glasmachers

Lead optimization in drug discovery requires efficiently navigating vast chemical space through iterative cycles to enhance molecular properties while preserving structural similarity to the original lead compound. Despite recent advances,…

Machine Learning · Computer Science 2025-09-29 Ziqing Wang , Yibo Wen , William Pattie , Xiao Luo , Weimin Wu , Jerry Yao-Chieh Hu , Abhishek Pandey , Han Liu , Kaize Ding

The (Non-Preemptive) Throughput Maximization problem is a natural and fundamental scheduling problem. We are given $n$ jobs, where each job $j$ is characterized by a processing time and a time window, contained in a global interval $[0,T)$,…

Data Structures and Algorithms · Computer Science 2026-04-01 Alexander Armbruster , Fabrizio Grandoni , Antoine Tinguely , Andreas Wiese

The problem of constrained reinforcement learning (CRL) holds significant importance as it provides a framework for addressing critical safety satisfaction concerns in the field of reinforcement learning (RL). However, with the introduction…

Machine Learning · Computer Science 2023-05-24 Chengbin Xuan , Feng Zhang , Faliang Yin , Hak-Keung Lam

Optimization is fundamental in many areas of science, from computer science and information theory to engineering and statistical physics, as well as to biology or social sciences. It typically involves a large number of variables and a…

Statistical Mechanics · Physics 2009-07-08 Lenka Zdeborová

Nonconvex and nonsmooth optimization problems are frequently encountered in much of statistics, business, science and engineering, but they are not yet widely recognized as a technology in the sense of scalability. A reason for this…

Optimization and Control · Mathematics 2018-01-19 Bo Jiang , Tianyi Lin , Shiqian Ma , Shuzhong Zhang

Combinatorial optimization assumes that all parameters of the optimization problem, e.g. the weights in the objective function is fixed. Often, these weights are mere estimates and increasingly machine learning techniques are used to for…

Machine Learning · Computer Science 2019-11-25 Jaynta Mandi , Emir Demirović , Peter. J Stuckey , Tias Guns

We consider solving linear optimization (LO) problems with uncertain objective coefficients. For such problems, we often employ robust optimization (RO) approaches by introducing an uncertainty set for the unknown coefficients. Typical RO…

Optimization and Control · Mathematics 2023-12-04 Ayaka Ueta , Mirai Tanaka , Ken Kobayashi , Kazuhide Nakata

A promising approach to optimal control of nonlinear systems involves iteratively linearizing the system and solving an optimization problem at each time instant to determine the optimal control input. Since this approach relies on online…

Optimization and Control · Mathematics 2025-01-30 Anran Li , John P. Swensen , Mehdi Hosseinzadeh

This work studies reinforcement learning (RL) in the context of multi-period supply chains subject to constraints, e.g., on production and inventory. We introduce Distributional Constrained Policy Optimization (DCPO), a novel approach for…

Machine Learning · Computer Science 2023-02-06 Jaime Sabal Bermúdez , Antonio del Rio Chanona , Calvin Tsay

Neural combinatorial optimization (NCO) aims at designing problem-independent and efficient neural network-based strategies for solving combinatorial problems. The field recently experienced growth by successfully adapting architectures…

Machine Learning · Computer Science 2020-11-13 Michal Lisicki , Arash Afkanpour , Graham W. Taylor

We consider several combinatorial optimization problems which combine the classic shop scheduling problems, namely open shop scheduling or job shop scheduling, and the shortest path problem. The objective of the obtained problem is to…

Data Structures and Algorithms · Computer Science 2013-09-03 Kameng Nip , Zhenbo Wang , Wenxun Xing

The MapReduce framework has firmly established itself as one of the most widely used parallel computing platforms for processing big data on tera- and peta-byte scale. Approaching it from a theoretical standpoint has proved to be…

Computational Complexity · Computer Science 2019-12-30 Fabian Frei , Koichi Wada

Recent advances in quantum computing and the increasing availability of quantum hardware have substantially enhanced the practical relevance of quantum approaches to discrete optimization. Among these, the Quadratic Unconstrained Binary…

Quantum Physics · Physics 2026-02-12 Felix P. Broesamle , Stefan Nickel

Neural solvers have demonstrated remarkable success in combinatorial optimization, often surpassing traditional heuristics in speed, solution quality, and generalization. However, their efficacy deteriorates significantly when confronted…

Neural and Evolutionary Computing · Computer Science 2025-11-14 Zhanhong Fang , Debing Wang , Jinbiao Chen , Jiahai Wang , Zizhen Zhang

In various game scenarios, selecting a fixed number of targets from multiple enemy units is an extremely challenging task. This difficulty stems from the complex relationship between the threat levels of enemy units and their feature…

Machine Learning · Computer Science 2025-04-28 Wuzhou Sun , Siyi Li , Qingxiang Zou , Zixing Liao

Safe reinforcement learning aims to learn the optimal policy while satisfying safety constraints, which is essential in real-world applications. However, current algorithms still struggle for efficient policy updates with hard constraint…

Machine Learning · Computer Science 2022-06-20 Linrui Zhang , Li Shen , Long Yang , Shixiang Chen , Bo Yuan , Xueqian Wang , Dacheng Tao

While first-order stationary points (FOSPs) are the traditional targets of non-convex optimization, they often correspond to undesirable strict saddle points. To circumvent this, attention has shifted towards second-order stationary points…

Computational Complexity · Computer Science 2026-04-03 Andreas Kontogiannis , Ioannis Panageas , Vasilis Pollatos