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Protein function prediction is a crucial task in bioinformatics, with significant implications for understanding biological processes and disease mechanisms. While the relationship between sequence and function has been extensively…

Quantitative Methods · Quantitative Biology 2024-09-04 Shania Mitra , Lei Huang , Manolis Kellis

Clinical dataset labels are rarely certain as annotators disagree and confidence is not uniform across cases. Typical aggregation procedures, such as majority voting, obscure this variability. In simple experiments on medical imaging…

Nowadays, due to the increasing amount of experimental data obtained by sequencing, the most interest is focused on determining the functions and characteristics of its individual parts of the genome instead of determining the nucleotide…

Genomics · Quantitative Biology 2021-02-09 Marina Galchenkova , Aleksei Korzhenkov

In computational biology and other sciences, researchers are frequently faced with a choice between several computational methods for performing data analyses. Benchmarking studies aim to rigorously compare the performance of different…

Constructing general knowledge by learning task-independent models of the world can help agents solve challenging problems. However, both constructing and evaluating such models remains an open challenge. The most common approaches to…

Artificial Intelligence · Computer Science 2021-04-15 Alex Kearney , Anna Koop , Patrick M. Pilarski

High throughput sequencing techniques have highly impactedon modern biology, widening the gap between sequenced andannotated data. Automatic annotation tools are thereforeof the foremost importance to guide biologists' experiments. However,…

Machine Learning · Statistics 2016-10-02 Luca Masera

Efficiency and scalability are obstacles that have not yet received a viable response from the human activity recognition research community. This paper proposes an activity recognition method. The knowledge model is in the form of…

Human-Computer Interaction · Computer Science 2021-09-08 Pouya Foudeh , Naomie Salim

Probabilistic logic programs are logic programs in which some of the facts are annotated with probabilities. This paper investigates how classical inference and learning tasks known from the graphical model community can be tackled for…

Artificial Intelligence · Computer Science 2020-02-19 Daan Fierens , Guy Van den Broeck , Joris Renkens , Dimitar Shterionov , Bernd Gutmann , Ingo Thon , Gerda Janssens , Luc De Raedt

In this paper we discuss how semantic annotations can be used to introduce mathematical algorithmic information of the underlying imperative code to enable compilers to produce code transformations that will enable better performance. By…

Programming Languages · Computer Science 2016-03-14 Daniel Rubio Bonilla , Colin W. Glass , Jan Kuper

Independent computational reproducibility of scientific results is rapidly becoming of pivotal importance in scientific progress as computation itself plays a more and more central role in so many branches of science. Historically,…

Quantitative Methods · Quantitative Biology 2016-08-25 Les Hatton , Gregory Warr

Artificial RNA molecules with novel functionality have many applications in synthetic biology, pharmacy and white biotechnology. The de novo design of such devices using computational methods and prediction tools is a resource-efficient…

Biomolecules · Quantitative Biology 2019-05-13 Stefan Hammer , Christian Günzel , Mario Mörl , Sven Findeiß

Fashion recommendation is a key research field in computational fashion research and has attracted considerable interest in the computer vision, multimedia, and information retrieval communities in recent years. Due to the great demand for…

Multimedia · Computer Science 2023-10-31 Yujuan Ding , Zhihui Lai , P. Y. Mok , Tat-Seng Chua

The language used by US courtroom actors in criminal trials has long been studied for biases. However, systematic studies for bias in high-stakes court trials have been difficult, due to the nuanced nature of bias and the legal expertise…

Computation and Language · Computer Science 2024-07-30 Andrea W Wen-Yi , Kathryn Adamson , Nathalie Greenfield , Rachel Goldberg , Sandra Babcock , David Mimno , Allison Koenecke

Genome annotation is essential for understanding the functional elements within genomes. While automated methods are indispensable for processing large-scale genomic data, they often face challenges in accurately predicting gene structures…

Genomics · Quantitative Biology 2025-04-01 Xiaomei Li , Alex Whan , Meredith McNeil , David Starns , Jessica Irons , Samuel C. Andrew , Rad Suchecki

Deep Learning and big data have shown tremendous success in bioinformatics and computational biology in recent years; artificial intelligence methods have also significantly contributed in the task of protein function classification. This…

Biomolecules · Quantitative Biology 2022-11-18 Divyanshu Aggarwal , Yasha Hasija

Citation recommendation aims to locate the important papers for scholars to cite. When writing the citing sentences, the authors usually hold different citing intents, which are referred to citation function in citation analysis. Since…

Information Retrieval · Computer Science 2025-01-31 Shutian Ma , Chengzhi Zhang , Heng Zhang , Zheng Gao

Combining quantum computers with classical compute power has become a standard means for developing algorithms that are eventually supposed to beat any purely classical alternatives. While in-principle advantages for solution quality or…

Quantum Physics · Physics 2026-01-23 Simon Thelen , Wolfgang Mauerer

Background:Typically, proteins perform key biological functions by interacting with each other. As a consequence, predicting which protein pairs interact is a fundamental problem. Experimental methods are slow, expensive, and may be error…

Biomolecules · Quantitative Biology 2022-02-08 Leonardo Martini , Adriano Fazzone , Luca Becchetti

Those seeking to reproduce a computational experiment often need to manually look at the code to see how to build necessary libraries, configure parameters, find data, and invoke the experiment; it is not automatic. Automatic…

Software Engineering · Computer Science 2023-07-24 Samuel Grayson , Reed Milewicz , Joshua Teves , Daniel S. Katz , Darko Marinov

Studying the function of proteins is important for understanding the molecular mechanisms of life. The number of publicly available protein structures has increasingly become extremely large. Still, the determination of the function of a…

Machine Learning · Computer Science 2018-03-02 Wajdi Dhifli , Abdoulaye Baniré Diallo