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There have been increasing reports that the diffusion coefficient of macromolecules depends on time and fluctuates randomly. Here, a novel method to elucidate the fluctuating diffusivity from trajectory data is developed. The time-averaged…

Statistical Mechanics · Physics 2017-10-25 Tomoshige Miyaguchi

Accurate detection of target molecules at low concentrations in the presence of a high concentration of undesired molecules is a major challenge for End Point (EP) assays. Non-specific binding of undesired molecules to receptors limits the…

Chemical Physics · Physics 2019-12-03 Deepak Gopalan , Pradeep R. Nair

We consider a simple mean reverting diffusion process, with piecewise constant drift and diffusion coefficients, discontinuous at a fixed threshold. We discuss estimation of drift and diffusion parameters from discrete observations of the…

Statistics Theory · Mathematics 2024-03-12 Sara Mazzonetto , Paolo Pigato

In Real-Time, Feedback-Driven Single Particle Tracking methods, measurements of the emission intensity from a labeled, nanometer-scale particle are used in a feedback loop to track the motion of the particle as it moves inside its native…

Optics · Physics 2025-12-03 Md Faysal Hossain , Sean B. Andersson

One key issue in the probability density function (PDF) approach for disperse two-phase turbulent flows is to close the diffusion term in the phase space. This study aimed to derive a kinetic equation for particle dispersion in turbulent…

Statistical Mechanics · Physics 2020-07-15 De-yu Zhong , Guang-qian Wang , Tie-jian Li , Ming-xi Zhang , You Xia

A common challenge in the natural sciences is to disentangle distinct, unknown sources from observations. Examples of this source separation task include deblending galaxies in a crowded field, distinguishing the activity of individual…

Machine Learning · Computer Science 2025-10-08 Sebastian Wagner-Carena , Aizhan Akhmetzhanova , Sydney Erickson

Self-diffusion coefficients, $D^*$, are routinely estimated from molecular dynamics simulations by fitting a linear model to the observed mean-squared displacements (MSDs) of mobile species. MSDs derived from simulation exhibit statistical…

Statistical Mechanics · Physics 2026-01-05 Andrew R. McCluskey , Samuel W. Coles , Benjamin J. Morgan

Single-file diffusion refers to the Brownian motion in narrow channels where particles cannot pass each other. In such processes, the diffusion of a tagged particle is typically normal at short times and becomes subdiffusive at long times.…

Statistical Mechanics · Physics 2026-02-23 Sören Schweers , Alexander P. Antonov , Artem Ryabov , Philipp Maass

Digital Surface Models (DSM) offer a wealth of height information for understanding the Earth's surface as well as monitoring the existence or change in natural and man-made structures. Classical height estimation requires multi-view…

Computer Vision and Pattern Recognition · Computer Science 2023-04-27 Isaac Corley , Peyman Najafirad

We describe a previously unexplored effect of the continuous spontaneous localization model whereby a correlation develops in the distributions of two nearby non-interacting particles following a period of diffusion. We propose the use of…

Quantum Physics · Physics 2014-11-27 Daniel Bedingham

Diffusion Models (DMs) have achieved great success in image generation and other fields. By fine sampling through the trajectory defined by the SDE/ODE solver based on a well-trained score model, DMs can generate remarkable high-quality…

Computer Vision and Pattern Recognition · Computer Science 2024-06-10 Bowen Zheng , Tianming Yang

A simple and fast analysis method to sort large data sets into groups with shared distinguishing characteristics is described, and applied to single molecular break junction conductance versus electrode displacement data. The method, based…

Mesoscale and Nanoscale Physics · Physics 2018-01-10 J. M. Hamill , X. T. Zhao , G. Mészáros , M. R. Bryce , M. Arenz

We present a robust approach to incorporating models for the time-variable broadening of the pulse profile due to scattering in the ionized interstellar medium into profile-domain pulsar timing analysis. We use this approach to…

Instrumentation and Methods for Astrophysics · Physics 2017-04-12 L. Lentati , M. Kerr , S. Dai , R. M. Shannon , G. Hobbs , S. Oslowski

The diffusion of particles trapped in long narrow channels occurs predominantly in one dimension. Here, molecular dynamics simulation is used to study the inertial dynamics of two-dimensional hard disks, confined to long, narrow,…

Soft Condensed Matter · Physics 2020-02-05 Mahdi Zarif , Richard K. Bowles

Atom probe tomography (APT) is routinely used for analyzing property-enhancing particles in the nanometer-size range and below, and plays a prominent role in the analysis of solute clusters. However, the question of how well these small…

Materials Science · Physics 2020-02-25 Frédéric De Geuser , Baptiste Gault

Hypoelliptic diffusion processes can be used to model a variety of phenomena in applications ranging from molecular dynamics to audio signal analysis. We study parameter estimation for such processes in situations where we observe some…

Methodology · Statistics 2007-10-30 Y. Pokern , A. M. Stuart , P. Wiberg

We present an accessible first course on diffusion models and flow matching for machine learning, aimed at a technical audience with no diffusion experience. We try to simplify the mathematical details as much as possible (sometimes…

Machine Learning · Computer Science 2024-06-25 Preetum Nakkiran , Arwen Bradley , Hattie Zhou , Madhu Advani

This paper proposes a belief propagation (BP)-based algorithm for sequential detection and estimation of multipath component (MPC) parameters based on radio signals. Under dynamic channel conditions with moving transmitter/receiver, the…

Information Theory · Computer Science 2022-05-24 Xuhong Li , Erik Leitinger , Alexander Venus , Fredrik Tufvesson

Single particle diffraction imaging experiments at free-electron lasers (FEL) have a great potential for structure determination of reproducible biological specimens that can not be crystallized. One of the challenges in processing the data…

Biological Physics · Physics 2013-10-16 O. M. Yefanov , I. A. Vartanyants

Information, ideas, and diseases, or more generally, contagions, spread over space and time through individual transmissions via social networks, as well as through external sources. A detailed picture of any diffusion process can be…

Social and Information Networks · Computer Science 2021-02-08 Fangcao Xu , Bruce Desmarais , Donna Peuquet
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