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Functional magnetic resonance imaging (fMRI) is an emerging neuroimaging modality that is commonly modeled as networks of Regions of Interest (ROIs) and their connections, named functional connectivity, for understanding the brain functions…

Neurons and Cognition · Quantitative Biology 2024-10-01 Haokai Zhao , Haowei Lou , Lina Yao , Yu Zhang

Objective motor skill assessment plays a critical role in fields such as surgery, where proficiency is vital for certification and patient safety. Existing assessment methods, however, rely heavily on subjective human judgment, which…

Neurons and Cognition · Quantitative Biology 2025-02-20 Anil Kamat , Rahul Rahul , Anirban Dutta , Lora Cavuoto , Uwe Kruger , Harry Burke , Matthew Hackett , Jack Norfleet , Steven Schwaitzberg , Suvranu De

Accurate diagnosis of psychiatric disorders plays a critical role in improving the quality of life for patients and potentially supports the development of new treatments. Many studies have been conducted on machine learning techniques that…

Machine Learning · Statistics 2019-04-15 Takashi Matsubara , Tetsuo Tashiro , Kuniaki Uehara

Effective connectivity analysis in functional magnetic resonance imaging (fMRI) studies directional interactions among brain regions and experimental stimuli. Dynamic causal modeling (DCM) is a widely used method to estimate effective…

Methodology · Statistics 2026-05-15 Kaitlyn R. Fales , Hyebin Song , Nicole A. Lazar

Resting-state functional MRI (rs-fMRI) is a rich imaging modality that captures spontaneous brain activity patterns, revealing clues about the connectomic organization of the human brain. While many rs-fMRI studies have focused on static…

Machine Learning · Computer Science 2019-08-20 Meenakshi Khosla , Keith Jamison , Amy Kuceyeski , Mert R. Sabuncu

Dynamic functional connectivity is an effective measure for the brain's responses to continuous stimuli. We propose an inferential method to detect the dynamic changes of brain networks based on time-varying graphical models. Whereas most…

Applications · Statistics 2020-06-23 Dingjue Ji , Junwei Lu , Yiliang Zhang , Hongyu Zhao , Siyuan Gao

Contemporary neuroimaging methods can shed light on the basis of human neural and cognitive specializations, with important implications for neuroscience and medicine. Different MRI acquisitions provide different brain networks at the…

Neurons and Cognition · Quantitative Biology 2016-02-23 C. Alonso-Montes , I. Diez , L. Remaki , I. Escudero , B. Mateos , Y. Rosseel , D. Marinazzo , S. Stramaglia , J. Cortes

Brain age prediction based on neuroimaging data could help characterize both the typical brain development and neuropsychiatric disorders. Pattern recognition models built upon functional connectivity (FC) measures derived from resting…

Computer Vision and Pattern Recognition · Computer Science 2018-01-15 Hongming Li , Theodore D. Satterthwaite , Yong Fan

Functional Magnetic Resonance Imaging (fMRI) is a primary modality for studying brain activity. Modeling spatial dependence of imaging data at different scales is one of the main challenges of contemporary neuroimaging, and it could allow…

Applications · Statistics 2016-06-16 Stefano Castruccio , Hernando Ombao , Marc G. Genton

In this paper, we present a novel and versatile method to study the dynamics of resting-state fMRI brain connectivity with a high temporal sensitivity. Whereas most existing methods often rely on dividing the time-series into larger…

Neurons and Cognition · Quantitative Biology 2016-01-14 William Hedley Thompson , Peter Fransson

Dynamic functional connectivity (DFC) analysis has been widely applied to functional magnetic resonance imaging (fMRI) data to reveal time-varying dynamic changes of brain states. The sliding window method is by far the most popular DFC…

Machine Learning · Computer Science 2024-11-07 Yongjie Duan , Vince D. Calhoun , Zhiying Long

Functional magnetic resonance imaging (fMRI) is one of the most popular methods for studying the human brain. Task-related fMRI data processing aims to determine which brain areas are activated when a specific task is performed and is…

Signal Processing · Electrical Eng. & Systems 2022-10-18 Paris A. Karakasis , Athanasios P. Liavas , Nicholas D. Sidiropoulos , Panagiotis G. Simos , Efrosini Papadaki

Understanding how spontaneous brain activity relates to stimulus-driven neural responses is a fundamental challenge in cognitive neuroscience. While task-based functional magnetic resonance imaging (fMRI) captures localized stimulus-evoked…

Neurons and Cognition · Quantitative Biology 2025-09-18 Chuyang Zhou , Ziao Ji , Daochang Liu , Dongang Wang , Chenyu Wang , Chang Xu

We investigate the relationship of resting-state fMRI functional connectivity estimated over long periods of time with time-varying functional connectivity estimated over shorter time intervals. We show that using Pearson's correlation to…

Neurons and Cognition · Quantitative Biology 2016-09-08 Richard F. Betzel , Makoto Fukushima , Ye He , Xi-Nian Zuo , Olaf Sporns

We construct embedded functional connectivity networks (FCN) from benchmark resting-state functional magnetic resonance imaging (rsfMRI) data acquired from patients with schizophrenia and healthy controls based on linear and nonlinear…

Neurons and Cognition · Quantitative Biology 2023-03-24 Ioannis Gallos , Evangelos Galaris , Constantinos Siettos

Functional data analysis, which models data as realizations of random functions over a continuum, has emerged as a useful tool for time series data. Often, the goal is to infer the dynamic connections (or time-varying conditional…

Methodology · Statistics 2024-12-10 Chunshan Liu , Daniel R. Kowal , James Doss-Gollin , Marina Vannucci

Functional connectivity (FC) derived from resting-state fMRI plays a critical role in personalized predictions such as age and cognitive performance. However, applying foundation models(FM) to fMRI data remains challenging due to its high…

Neurons and Cognition · Quantitative Biology 2025-08-26 Yanwen Wang , Xinglin Zhao , Yijin Song , Xiaobo Liu , Yanrong Hao , Rui Cao , Xin Wen

Functional concurrent, or varying-coefficient, regression models are commonly used in biomedical and clinical settings to investigate how the relation between an outcome and observed covariate varies as a function of another covariate. In…

Objective: fMRI and derived measures such as functional connectivity (FC) have been used to predict brain age, general fluid intelligence, psychiatric disease status, and preclinical neurodegenerative disease. However, it is not always…

Quantitative Methods · Quantitative Biology 2024-05-14 Anton Orlichenko , Gang Qu , Ziyu Zhou , Anqi Liu , Hong-Wen Deng , Zhengming Ding , Julia M. Stephen , Tony W. Wilson , Vince D. Calhoun , Yu-Ping Wang

Functional connectivity (FC) as derived from fMRI has emerged as a pivotal tool in elucidating the intricacies of various psychiatric disorders and delineating the neural pathways that underpin cognitive and behavioral dynamics inherent to…

Neurons and Cognition · Quantitative Biology 2024-01-22 Gang Qu , Anton Orlichenko , Junqi Wang , Gemeng Zhang , Li Xiao , Aiying Zhang , Zhengming Ding , Yu-Ping Wang