Related papers: Multiscale analysis of signalling processes in tis…
We present and analyse a model for cell signalling processes in biological tissues. The model includes diffusion and nonlinear reactions on the cell surfaces, and both inter- and intracellular signalling. Using techniques from the theory of…
In the present paper, a new three-scale asymptotic homogenization method is proposed to study the electrical behavior of the cardiac tissue structure with multiple heterogeneities at two different levels. The first level is associated with…
A coupled map is suggested to investigate various spatial or temporal designs in biology: Several cells (or tissues) in an organ are considered as connected to each other in terms of some molecular diffusions or electrical potential…
We derive an equation that governs the spatiotemporal dynamics of small amplitude alternans in paced cardiac tissue. We show that a pattern-forming linear instability leads to the spontaneous formation of stationary or traveling waves whose…
We study the homogenization of a novel microscopic tridomain system, allowing for a more detailed analysis of the properties of cardiac conduction than the classical bidomain and monodomain models. In (Acta Appl.Math. 179 (2022) 1--35), we…
Mechanical signaling plays a key role in biological processes like embryo development and cancer growth. One prominent way to probe mechanical properties of tissues is to study their response to externally applied forces. Using a…
In this paper we generalize the periodic unfolding method and the notion of two-scale convergence on surfaces of periodic microstructures to locally periodic situations. The methods that we introduce allow us to consider a wide range of…
State of the art research and treatment of biological tissues require accurate and efficient methods for describing their mechanical properties. Indeed, micromechanics motivated approaches provide a systematic method for elevating relevant…
This paper presents a nonlinear reaction-diffusion-fluid system that simulates radiofrequency ablation within cardiac tissue. The model conveys the dynamic evolution of temperature and electric potential in both the fluid and solid regions,…
In this paper, we are dealing with a rigorous homogenization result at two different levels for the bidomain model of cardiac electro-physiology. The first level associated with the mesoscopic structure such that the cardiac tissue consists…
The clinical application of patient-specific modelling of the heart can provide valuable insights in supplementing and advancing methods of diagnosis as well as helping to devise the best possible therapeutic approach for each individual…
We present a Bayesian approach to estimate the parameters of mathematical models of cardiac electrophysiology with quantified uncertainty. Such models capture the dynamics of the electrical signal that coordinates the muscle cell…
A non-local dynamic homogenization technique for the analysis of a viscoelastic heterogeneous material which displays a periodic microstructure is herein proposed. The asymptotic expansion of the micro-displacement field in the transformed…
On the basis of a quite realistic ionic Fenton--Karma model of the cardiac tissue we consider the problem of defibrillation by a local weak forcing. In contrast to other systems, this model accurately reproduces the most essential…
We study the signal percolation through heart-like biological system. Starting from an initial distribution of waiting and inactive cells with probabilities $p$ and $(1-p)$ respectively, the signal propagation is observed in terms of active…
We discuss open problems related to the stochastic modeling of cardiac function. The work is based on an experimental investigation of the dynamics of heart rate variability (HRV) in the absence of respiratory perturbations. We consider…
Recent studies in mammalian hearts show that left ventricular wall thickening is an important mechanism for systolic ejection and that during contraction the cardiac muscle develops significant stresses in the muscular cross-fiber…
Spatiotemporal patterns are common in biological systems. For electrically-coupled cells previous studies of pattern formation have mainly used external forcing as the main bifurcation parameter. The purpose of this paper is to show that…
Biological cells sense and respond to mechanical forces, but how such a mechanosensing proccess takes place in a nonlinear inhomogeneous fibrous matrix remains unknown. We show that cells in a fibrous matrix induce deformation fields that…
In this work we upscale a prototypical kinetic transport equation which models a cell population moving in a fibrous environment with a chemo- or haptotactic signal influencing both the direction and the magnitude of the cell velocity. The…