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Jarzynski's theorem is a well-known equality in statistical mechanics, which relates fluctuations in the work performed during a non-equilibrium transformation of a system, to the free-energy difference between two equilibrium ensembles. In…

High Energy Physics - Lattice · Physics 2016-08-16 Michele Caselle , Gianluca Costagliola , Alessandro Nada , Marco Panero , Arianna Toniato

Almost 25 years ago, Jarzynski published a paper in which it was asserted: the work done, W, in driving a system from state A to state B, characterized by the Helmholtz free energies FA and FB, satisfies an equality in which an average over…

General Physics · Physics 2022-06-07 Ronald F. Fox

Jarzynski's equality [1] allows us to investigate free energy landscapes (FELs) by constructing distributions of work performed on a system from an initial ensemble of states to final states. This work is experimentally measured by…

Biological Physics · Physics 2011-05-24 Van Ngo

One particle in a classical perfect gas is driven out of equilibrium by changing its mass over a short time interval. The work done on the driven particle depends on its collisions with the other particles in the gas. This model thus…

Statistical Mechanics · Physics 2014-04-22 T. G. Philbin , J. Anders

Almost 25 years ago, Jarzynski published a paper in which it was asserted: the work done, W, in driving a system from state A to state B, characterized by the Helmholtz free energies FA and FB, satisfies an equality in which an average over…

General Physics · Physics 2021-08-25 Ronald F. Fox

The Jarzynski equality (JE), which connects the equilibrium free energy with non-equilibrium work statistics, plays a crucial role in quantum thermodynamics. Although practical quantum systems are usually multi-level systems, most tests of…

Quantum Physics · Physics 2023-10-26 Wenquan Liu , Zhibo Niu , Wei Cheng , Xin Li , Chang-Kui Duan , Zhangqi Yin , Xing Rong , Jiangfeng Du

In this short communication, I give a very simple derivation of the Jarzynski equality, which allows to compute the free energy difference of a body, which is driven between two equilibrium states $A$ and $B$ by an external (time-dependent)…

Statistical Mechanics · Physics 2016-08-16 Frédéric Douarche

Fluctuation relations allow for the computation of equilibrium properties, like free energy, from an ensemble of non-equilibrium dynamics simulations. Computing them for quantum systems, however, can be difficult, as performing dynamic…

Quantum Physics · Physics 2021-09-07 Lindsay Bassman , Katherine Klymko , Diyi Liu , Norman M. Tubman , Wibe A. de Jong

The well-known Jarzynski equality, often written in the form $e^{-\beta\Delta F}=\langle e^{-\beta W}\rangle$, provides a non-equilibrium means to measure the free energy difference $\Delta F$ of a system at the same inverse temperature…

Statistical Mechanics · Physics 2017-08-22 Jiawen Deng , Juan D. Jaramillo , Peter Hanggi , Jiangbin Gong

Jarzynski's equality provides an elegant and powerful tool to directly compute differences in free energy in Monte Carlo simulations and it can be readily extended to lattice gauge theories to compute a large set of physically interesting…

High Energy Physics - Lattice · Physics 2018-04-18 Alessandro Nada , Michele Caselle , Marco Panero

We derive exact fluctuation equalities for open systems that recover free energy differences between two equilibrium endpoints connected by nonequilibrium processes with arbitrary dynamics and coupling. The exponential of the free energy…

Statistical Mechanics · Physics 2025-12-15 Mohammad Rahbar , Christopher J. Stein

The Jarzynski equality (JE) is analyzed in regard to its validity for both quasi-static transformations in the thermodynamic limit and Hamiltonian evolutions of the work protocol. In the first case, we show that the JE holds for isothermal…

Statistical Mechanics · Physics 2020-05-15 Amilcare Porporato , Salvatore Calabrese

The nonequilibrium work relation, or Jarzynski equality, establishes a statistical relationship between a series of nonequilibrium experiments on a system subjected to thermal fluctuations and a hypothetical experiment at thermodynamic…

Statistical Mechanics · Physics 2024-11-19 Jean-Luc Garden

With the traditional equilibrium molecular simulations, it is usually difficult to efficiently visit the whole conformational space in complex systems, which are separated into some metastable conformational regions by high free energy…

Soft Condensed Matter · Physics 2019-08-17 Cheng Yang , Biao Wan , Shun Xu , Yanting Wang , Xin Zhou

A main goal of single-molecule experiments is to evaluate equilibrium free energy differences by applying fluctuation relations to repeated work measurements along irreversible processes. We quantify the error that is made in a free energy…

Statistical Mechanics · Physics 2009-06-22 Alessandro Mossa , Sara de Lorenzo , Josep Maria Huguet , Felix Ritort

In this paper, we study Jarzynski's equality and fluctuation theorems for diffusion processes. While some of the results considered in the current work are known in the (mainly physics) literature, we review and generalize these…

Mathematical Physics · Physics 2019-04-09 Carsten Hartmann , Christof Schuette , Wei Zhang

The connection between work and changes in the Hamiltonian for a system with a time-dependent Hamiltonian has recently been called into question, casting doubt on the usefulness of the Jarzynski equality for calculating free energy changes.…

Statistical Mechanics · Physics 2015-05-13 Eric N. Zimanyi , Robert J. Silbey

We perform, with the help of cloud computing resources, extensive Langevin simulations which provide free energy estimates for unbiased three dimensional polymer translocation. We employ the Jarzynski equality in its rigorous setting, to…

Statistical Mechanics · Physics 2015-06-18 Felipe Mondaini , Luca Moriconi

Despite the strength of Molecular Dynamics simulations in providing insights into the microscopic details of phenomenon in many fields in materials science, physics and biology, the biggest barrier is its limited timescale which is several…

Materials Science · Physics 2026-05-19 Mahdi Tavakol , Jin-Chong Tan , Alexander M. Korsunsky

We present a generalization of Jarzynski's Equality, applicable to quantum systems, relating discretized mechanical work and free-energy changes. The theory is based on a step-wise pulling protocol. We find that work distribution functions…

Quantum Physics · Physics 2012-09-21 Van A. Ngo , Stephan Haas