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Predicting the binding sites of target proteins plays a fundamental role in drug discovery. Most existing deep-learning methods consider a protein as a 3D image by spatially clustering its atoms into voxels and then feed the voxelized…

Biomolecules · Quantitative Biology 2024-07-24 Yang Zhang , Zhewei Wei , Ye Yuan , Chongxuan Li , Wenbing Huang

Prostate cancer is the most common malignant tumors in men but prostate Magnetic Resonance Imaging (MRI) analysis remains challenging. Besides whole prostate gland segmentation, the capability to differentiate between the blurry boundary of…

Protein-ligand interactions (PLIs) are fundamental to biochemical research and their identification is crucial for estimating biophysical and biochemical properties for rational therapeutic design. Currently, experimental characterization…

Machine Learning · Statistics 2021-12-01 Carter Knutson , Mridula Bontha , Jenna A. Bilbrey , Neeraj Kumar

The accurate prediction of changes in protein stability under multiple amino acid substitutions is essential for realising true in-silico protein re-design. To this purpose, we propose improvements to state-of-the-art Deep learning (DL)…

Biomolecules · Quantitative Biology 2023-06-01 Sebastien Boyer , Sam Money-Kyrle , Oliver Bent

Non protein coding regions of the human genome contain many complex patterns which regulate the cellular activity. Studying the human genome is limited by the lack of understanding of its features and their complex interactions. However,…

Genomics · Quantitative Biology 2017-08-15 Kerim Arioglu , Umut Eser

Spiking neural networks (SNNs) have closer dynamics to the brain than current deep neural networks. Their low power consumption and sample efficiency make these networks interesting. Recently, several deep convolutional spiking neural…

Computer Vision and Pattern Recognition · Computer Science 2022-11-01 Shahriar Rezghi Shirsavar , Mohammad-Reza A. Dehaqani

Deep Learning plays a significant role in assisting humans in many aspects of their lives. As these networks tend to get deeper over time, they extract more features to increase accuracy at the cost of additional inference latency. This…

Machine Learning · Computer Science 2021-08-12 Mehrshad Zandigohar , Deniz Erdogmus , Gunar Schirner

Recently, very deep convolutional neural networks (CNNs) have shown outstanding performance in object recognition and have also been the first choice for dense classification problems such as semantic segmentation. However, repeated…

Computer Vision and Pattern Recognition · Computer Science 2016-11-28 Guosheng Lin , Anton Milan , Chunhua Shen , Ian Reid

Spatiotemporal information is at the core of diverse sensory processing and computational tasks. Feed-forward spiking neural networks can be used to solve these tasks while offering potential benefits in terms of energy efficiency by…

Machine Learning · Computer Science 2026-03-11 Jann Krausse , Zhe Su , Kyrus Mama , Maryada , Klaus Knobloch , Giacomo Indiveri , Jürgen Becker

The convergence of communication and computation, along with the integration of machine learning and artificial intelligence, stand as key empowering pillars for the sixth-generation of communication systems (6G). This paper considers a…

Information Theory · Computer Science 2024-06-07 Robert-Jeron Reifert , Hayssam Dahrouj , Alaa Alameer Ahmad , Haris Gacanin , Aydin Sezgin

In this study, we propose a novel approach, termed boundary integrated neural networks (BINNs), for analyzing in-plane crack problems within the framework of linear elastic fracture mechanics. The proposed approach integrates artificial…

Computational Engineering, Finance, and Science · Computer Science 2025-03-03 Peijun Zhang , Yan Gu , Okyay Altay , Chuanzeng Zhang

Nuclear segmentation is an important step for profiling aberrant regions of histology sections. However, segmentation is a complex problem as a result of variations in nuclear geometry (e.g., size, shape), nuclear type (e.g., epithelial,…

Computer Vision and Pattern Recognition · Computer Science 2018-02-16 Mina Khoshdeli , Bahram Parvin

Substring kernels are classical tools for representing biological sequences or text. However, when large amounts of annotated data are available, models that allow end-to-end training such as neural networks are often preferred. Links…

Machine Learning · Statistics 2019-10-18 Dexiong Chen , Laurent Jacob , Julien Mairal

With the advancement in computing power over last decades, deep neural networks (DNN), consisting of two or more hidden layers with large number of nodes, are being suggested as an alternate to commonly used single-hidden-layer neural…

Neural and Evolutionary Computing · Computer Science 2019-10-10 Mahesh Pal

Recent studies in deep learning-based speech separation have proven the superiority of time-domain approaches to conventional time-frequency-based methods. Unlike the time-frequency domain approaches, the time-domain separation systems…

Audio and Speech Processing · Electrical Eng. & Systems 2020-03-30 Yi Luo , Zhuo Chen , Takuya Yoshioka

Since the BOSS competition, in 2010, most steganalysis approaches use a learning methodology involving two steps: feature extraction, such as the Rich Models (RM), for the image representation, and use of the Ensemble Classifier (EC) for…

Multimedia · Computer Science 2018-01-15 Lionel Pibre , Pasquet Jérôme , Dino Ienco , Marc Chaumont

There has been a steady increase in the incidence of skin cancer worldwide, with a high rate of mortality. Early detection and segmentation of skin lesions are crucial for timely diagnosis and treatment, necessary to improve the survival…

Computer Vision and Pattern Recognition · Computer Science 2019-12-04 Sulaiman Vesal , Nishant Ravikumar , Andreas Maier

We characterize a prevalent weakness of deep neural networks (DNNs)---overthinking---which occurs when a DNN can reach correct predictions before its final layer. Overthinking is computationally wasteful, and it can also be destructive…

Machine Learning · Computer Science 2019-05-10 Yigitcan Kaya , Sanghyun Hong , Tudor Dumitras

Aero-engine is the core component of aircraft and other spacecraft. The high-speed rotating blades provide power by sucking in air and fully combusting, and various defects will inevitably occur, threatening the operation safety of…

Computer Vision and Pattern Recognition · Computer Science 2024-09-24 Hongbing Shang , Qixiu Yang , Chuang Sun , Xuefeng Chen , Ruqiang Yan

Splice detection models are the need of the hour since splice manipulations can be used to mislead, spread rumors and create disharmony in society. However, there is a severe lack of image splicing datasets, which restricts the capabilities…

Computer Vision and Pattern Recognition · Computer Science 2024-01-17 Ankit Yadav , Dinesh Kumar Vishwakarma
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