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The discovery of motifs underlying gene expression is a challenging one. Some of these motifs are known transcription factors, but sequence inspection often provides valuable clues, even discovery of novel motifs with uncharacterized…

Genomics · Quantitative Biology 2007-05-23 Arvind Rao , Alfred O. Hero , David J. States , James Douglas Engel

In this paper we develop a novel Topological Data Analysis (TDA) approach for studying graph representations of time series of dynamical systems. Specifically, we show how persistent homology, a tool from TDA, can be used to yield a…

Chaotic Dynamics · Physics 2020-01-28 Audun Myers , Elizabeth Munch , Firas A. Khasawneh

Deep neural networks excel in mapping genomic DNA sequences to associated readouts (e.g., protein-DNA binding). Beyond prediction, the goal of these networks is to reveal to scientists the underlying motifs (and their syntax) which drive…

Genomics · Quantitative Biology 2024-10-10 Alex M. Tseng , Gokcen Eraslan , Tommaso Biancalani , Gabriele Scalia

Graphs are a powerful representation tool in machine learning applications, with link prediction being a key task in graph learning. Temporal link prediction in dynamic networks is of particular interest due to its potential for solving…

Machine Learning · Computer Science 2024-01-17 Sanaz Hasanzadeh Fard , Mohammad Ghassemi

Motif discovery is a fundamental step in data mining tasks for time-series data such as clustering, classification and anomaly detection. Even though many papers have addressed the problem of how to find motifs in time-series by proposing…

Machine Learning · Computer Science 2020-04-20 Maria Inês Silva , Roberto Henriques

Recently, the visibility graph has been introduced as a novel view for analyzing time series, which maps it to a complex network. In this paper, we introduce new algorithm of visibility, "cross-visibility", which reveals the conjugation of…

Data Analysis, Statistics and Probability · Physics 2015-06-12 Saeed Mehraban , Amirhossein Shirazi , Maryam Zamani , Gholamreza Jafari

Frequent and structurally related subgraphs, also known as network motifs, are valuable features of many graph datasets. However, the high computational complexity of identifying motif sets in arbitrary datasets (motif mining) has limited…

Machine Learning · Computer Science 2022-06-08 Carlos Oliver , Dexiong Chen , Vincent Mallet , Pericles Philippopoulos , Karsten Borgwardt

Graphs are a powerful tool for representing and analyzing unstructured, non-Euclidean data ubiquitous in the healthcare domain. Two prominent examples are molecule property prediction and brain connectome analysis. Importantly, recent works…

Machine Learning · Computer Science 2022-04-04 Kamilia Mullakaeva , Luca Cosmo , Anees Kazi , Seyed-Ahmad Ahmadi , Nassir Navab , Michael M. Bronstein

Graphs are widely used for describing systems made up of many interacting components and for understanding the structure of their interactions. Various statistical models exist, which describe this structure as the result of a combination…

Methodology · Statistics 2021-06-28 Louis Duvivier , Rémy Cazabet , Céline Robardet

The goal of data-driven learning of dynamical systems is to interpret time series as a continuous observation of an underlying dynamical system. This task is not well-posed for a variety of reasons - such as multiple co-existing…

Dynamical Systems · Mathematics 2026-01-21 Suddhasattwa Das , Tomoharu Suda

Graph neural networks (GNNs) have emerged as powerful tools for learning protein structures by capturing spatial relationships at the residue level. However, existing GNN-based methods often face challenges in learning multiscale…

Machine Learning · Computer Science 2026-02-03 Shih-Hsin Wang , Yuhao Huang , Taos Transue , Justin Baker , Jonathan Forstater , Thomas Strohmer , Bao Wang

Graphical models provide a powerful methodology for learning the conditional independence structure in multivariate data. Inference is often focused on estimating individual edges in the latent graph. Nonetheless, there is increasing…

Methodology · Statistics 2023-12-15 Willem van den Boom , Maria De Iorio , Alexandros Beskos

This work presents a framework for studying temporal networks using zigzag persistence, a tool from the field of Topological Data Analysis (TDA). The resulting approach is general and applicable to a wide variety of time-varying graphs. For…

Computational Geometry · Computer Science 2023-08-15 Audun Myers , David Muñoz , Firas Khasawneh , Elizabeth Munch

Dynamic networks reflect temporal changes occurring to the graph's structure and are used to model a wide variety of problems in many application fields. We investigate the design space of dynamic graph visualization along two major…

Human-Computer Interaction · Computer Science 2022-09-07 Velitchko Filipov , Alessio Arleo , Markus Bögl , Silvia Miksch

Large continuous-time Markov chains with exponentially small transition rates arise in modeling complex systems in physics, chemistry and biology. We propose a constructive graph-algorithmic approach to determine the sequence of critical…

Probability · Mathematics 2017-02-01 Tingyue Gan , Maria Cameron

This paper focuses on modeling the dynamic attributes of a dynamic network with a fixed number of vertices. These attributes are considered as time series which dependency structure is influenced by the underlying network. They are modeled…

Methodology · Statistics 2019-11-11 Jonas Krampe

Various important and useful quantities or measures that characterize the topological network structure are usually investigated for a network, then they are averaged over the samples. In this paper, we propose an explicit representation by…

Physics and Society · Physics 2016-09-02 Yukio Hayashi

Recent years have seen a surge of interest in the analysis of complex networks, facilitated by the availability of relational data and the increasingly powerful computational resources that can be employed for their analysis. Naturally, the…

Physics and Society · Physics 2013-08-08 Jean-Charles Delvenne , Michael T. Schaub , Sophia N. Yaliraki , Mauricio Barahona

An emerging way to deal with high-dimensional non-euclidean data is to assume that the underlying structure can be captured by a graph. Recently, ideas have begun to emerge related to the analysis of time-varying graph signals. This work…

Machine Learning · Computer Science 2017-05-08 Francesco Grassi , Andreas Loukas , Nathanaël Perraudin , Benjamin Ricaud

The topology of social networks can be understood as being inherently dynamic, with edges having a distinct position in time. Most characterizations of dynamic networks discretize time by converting temporal information into a sequence of…

Data Analysis, Statistics and Probability · Physics 2012-12-03 Aaron Clauset , Nathan Eagle
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