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Network-based analyses of high-throughput genomics data provide a holistic, systems-level understanding of various biological mechanisms for a common population. However, when estimating multiple networks across heterogeneous…

The popularity of penalized regression in high-dimensional data analysis has led to a demand for new inferential tools for these models. False discovery rate control is widely used in high-dimensional hypothesis testing, but has only…

Methodology · Statistics 2019-01-24 Ryan Miller , Patrick Breheny

We present a new method to propagate lower bounds on conditional probability distributions in conventional Bayesian networks. Our method guarantees to provide outer approximations of the exact lower bounds. A key advantage is that we can…

Artificial Intelligence · Computer Science 2012-05-14 Daniel Andrade , Bernhard Sick

Latent position models are widely used for the analysis of networks in a variety of research fields. In fact, these models possess a number of desirable theoretical properties, and are particularly easy to interpret. However, statistical…

Computation · Statistics 2023-03-08 Riccardo Rastelli , Florian Maire , Nial Friel

Learning the differential statistical dependency network between two contexts is essential for many real-life applications, mostly in the high dimensional low sample regime. In this paper, we propose a novel differential network estimator…

Machine Learning · Computer Science 2022-04-25 Arshdeep Sekhon , Zhe Wang , Yanjun Qi

This article explores the estimation of precision matrices in high-dimensional Gaussian graphical models. We address the challenge of improving the accuracy of maximum likelihood-based precision estimation through penalization.…

Methodology · Statistics 2023-12-27 A. Bekker , A. Kheyri , M. Arashi

Augmenting a smooth cost function with an $\ell_1$ penalty allows analysts to efficiently conduct estimation and variable selection simultaneously in sophisticated models and can be efficiently implemented using proximal gradient methods.…

Machine Learning · Statistics 2024-12-10 Nathan Wycoff , Lisa O. Singh , Ali Arab , Katharine M. Donato

Linear discriminant analysis is a widely used method for classification. However, the high dimensionality of predictors combined with small sample sizes often results in large classification errors. To address this challenge, it is crucial…

Machine Learning · Statistics 2025-01-09 Hongzhe Zhang , Arnab Auddy , Hongzhe Lee

Changepoint detection is a technique used to identify significant shifts in sequences and is widely used in fields such as finance, genomics, and medicine. To identify the changepoints, dynamic programming (DP) algorithms, particularly…

Machine Learning · Statistics 2025-07-29 Tung L Nguyen , Toby Dylan Hocking

Standard likelihood penalties to learn Gaussian graphical models are based on regularising the off-diagonal entries of the precision matrix. Such methods, and their Bayesian counterparts, are not invariant to scalar multiplication of the…

Methodology · Statistics 2023-11-16 Jack Storror Carter , David Rossell , Jim Q. Smith

Automated segmentation of hard exudates in colour fundus images is a challenge task due to issues of extreme class imbalance and enormous size variation. This paper aims to tackle these issues and proposes a dual-branch network with…

Computer Vision and Pattern Recognition · Computer Science 2021-05-07 Qing Liu , Haotian Liu , Yixiong Liang

The Lasso is a very well known penalized regression model, which adds an $L_{1}$ penalty with parameter $\lambda_{1}$ on the coefficients to the squared error loss function. The Fused Lasso extends this model by also putting an $L_{1}$…

Computation · Statistics 2009-10-06 Holger Hoefling

The paper proposes a new covariance estimator for large covariance matrices when the variables have a natural ordering. Using the Cholesky decomposition of the inverse, we impose a banded structure on the Cholesky factor, and select the…

Applications · Statistics 2008-12-18 Elizaveta Levina , Adam Rothman , Ji Zhu

Diagnosis of breast cancer has been well studied in the past. Multiple linear programming models have been devised to approximate the relationship between cell features and tumour malignancy. However, these models are less capable in…

Machine Learning · Computer Science 2020-02-21 Ke Quan

We introduce the localized Lasso, which is suited for learning models that are both interpretable and have a high predictive power in problems with high dimensionality $d$ and small sample size $n$. More specifically, we consider a function…

Machine Learning · Statistics 2016-10-17 Makoto Yamada , Koh Takeuchi , Tomoharu Iwata , John Shawe-Taylor , Samuel Kaski

The lasso has been studied extensively as a tool for estimating the coefficient vector in the high-dimensional linear model; however, considerably less is known about estimating the error variance in this context. In this paper, we propose…

Methodology · Statistics 2019-07-22 Guo Yu , Jacob Bien

One of the most important steps toward interpretability and explainability of neural network models is feature selection, which aims to identify the subset of relevant features. Theoretical results in the field have mostly focused on the…

Machine Learning · Computer Science 2020-10-19 Vu Dinh , Lam Si Tung Ho

Sparse networks can be found in a wide range of applications, such as biological and communication networks. Inference of such networks from data has been receiving considerable attention lately, mainly driven by the need to understand and…

Systems and Control · Electrical Eng. & Systems 2024-12-20 Junyang Jin , Ye Yuan , Jorge Goncalves

We show how to treat systematic uncertainties using Bayesian deep networks for regression. First, we analyze how these networks separately trace statistical and systematic uncertainties on the momenta of boosted top quarks forming fat jets.…

High Energy Physics - Phenomenology · Physics 2020-12-23 Gregor Kasieczka , Michel Luchmann , Florian Otterpohl , Tilman Plehn

This paper provides a comprehensive and detailed derivation of the backpropagation algorithm for graph convolutional neural networks using matrix calculus. The derivation is extended to include arbitrary element-wise activation functions…

Machine Learning · Computer Science 2024-08-05 Yen-Che Hsiao , Rongting Yue , Abhishek Dutta