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Genome analysis fundamentally starts with a process known as read mapping, where sequenced fragments of an organism's genome are compared against a reference genome. Read mapping is currently a major bottleneck in the entire genome analysis…

Hardware Architecture · Computer Science 2020-10-29 Mohammed Alser , Zülal Bingöl , Damla Senol Cali , Jeremie Kim , Saugata Ghose , Can Alkan , Onur Mutlu

Document categorization, which aims to assign a topic label to each document, plays a fundamental role in a wide variety of applications. Despite the success of existing studies in conventional supervised document classification, they are…

Computation and Language · Computer Science 2023-10-24 Yu Zhang , Yu Meng , Jiaxin Huang , Frank F. Xu , Xuan Wang , Jiawei Han

We present the first comprehensive study on automatic knowledge base construction for two prevalent commonsense knowledge graphs: ATOMIC (Sap et al., 2019) and ConceptNet (Speer et al., 2017). Contrary to many conventional KBs that store…

Computation and Language · Computer Science 2019-06-18 Antoine Bosselut , Hannah Rashkin , Maarten Sap , Chaitanya Malaviya , Asli Celikyilmaz , Yejin Choi

Biologists study Diatoms, a fundamental algae, to assess the health of aquatic systems. Diatom specimens have traditionally been preserved on analog slides, where a single slide can contain thousands of these microscopic organisms.…

Information Retrieval · Computer Science 2024-11-04 Kio Polson , Marina Potapova , Uttam Meena , Chad Peiper , Joshua Brown , Joshua Agar , Jane Greenberg

The federated learning paradigm is wellsuited for the field of medical image analysis, as it can effectively cope with machine learning on isolated multicenter data while protecting the privacy of participating parties. However, current…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Zhekai Zhou , Guibo Luo , Mingzhi Chen , Zhenyu Weng , Yuesheng Zhu

At this moment, databanks worldwide contain brain images of previously unimaginable numbers. Combined with developments in data science, these massive data provide the potential to better understand the genetic underpinnings of brain…

Machine Learning · Statistics 2025-01-30 Santiago Silva , Boris Gutman , Eduardo Romero , Paul M Thompson , Andre Altmann , Marco Lorenzi

We examine the application of narrative strategies to present a complex and unfamiliar metagenomics dataset to the public in a science museum. Our dataset contains information about microbial gene expressions that scientists use to infer…

Graphics · Computer Science 2023-08-16 Keshav Dasu , Kwan-Liu Ma , Joyce Ma , Jennifer Frazier

Incomplete knowledge of metabolic processes hinders the accuracy of GEnome-scale Metabolic models (GEMs), which in turn impedes advancements in systems biology and metabolic engineering. Existing gap-filling methods typically rely on…

Molecular Networks · Quantitative Biology 2024-09-23 Xiaoyi Liu , Hongpeng Yang , Chengwei Ai , Ruihan Dong , Yijie Ding , Qianqian Yuan , Jijun Tang , Fei Guo

Metagenomics has lowered the barrier to microbial discovery--enabling the identification of novel microbes without isolation--but cultures remain imperative for the deep study of microbes. Cultivation and isolation of non-model microbes…

Molecular Networks · Quantitative Biology 2026-02-26 Olivia Bulka , Chabname Ghassemi Nedjad , Loïc Paulevé , Sylvain Prigent , Clémence Frioux

A key obstacle in automated analytics and meta-learning is the inability to recognize when different datasets contain measurements of the same variable. Because provided attribute labels are often uninformative in practice, this task may be…

Machine Learning · Computer Science 2019-09-12 Jonas Mueller , Alex Smola

Genome sequence analysis plays a pivotal role in enabling many medical and scientific advancements in personalized medicine, outbreak tracing, and forensics. However, the analysis of genome sequencing data is currently bottlenecked by the…

Hardware Architecture · Computer Science 2021-11-04 Damla Senol Cali

Quantifying the similarity between datasets has widespread applications in statistics and machine learning. The performance of a predictive model on novel datasets, referred to as generalizability, depends on how similar the training and…

Methodology · Statistics 2025-06-18 Marieke Stolte , Franziska Kappenberg , Jörg Rahnenführer , Andrea Bommert

In biomedical research, to obtain more accurate prediction results from a target study, leveraging information from multiple similar source studies is proved to be useful. However, in many biomedical applications based on real-world data,…

Methodology · Statistics 2025-12-29 Xiaokang Liu , Jie Hu , Naimin Jing , Yang Ning , Cheng Yong Tang , Runze Li , Yong Chen

Over the recent years, the field of whole metagenome shotgun sequencing has witnessed significant growth due to the high-throughput sequencing technologies that allow sequencing genomic samples cheaper, faster, and with better coverage than…

Genomics · Quantitative Biology 2014-04-04 Sohan Seth , Niko Välimäki , Samuel Kaski , Antti Honkela

The effective visualization of genomic data is crucial for exploring and interpreting complex relationships within and across genes and genomes. Despite advances in developing dedicated bioinformatics software, common visualization tools…

Genomics · Quantitative Biology 2024-11-22 Thomas Hackl , Markus Ankenbrand , Bart van Adrichem , David Wilkins , Kristina Haslinger

Item indexing, which maps a large corpus of items into compact discrete representations, is critical for both discriminative and generative recommender systems, yet existing Vector Quantization (VQ)-based approaches struggle with the highly…

Information Retrieval · Computer Science 2026-01-29 Jing Yan , Yimeng Bai , Zongyu Liu , Yahui Liu , Junwei Wang , Jingze Huang , Haoda Li , Sihao Ding , Shaohui Ruan , Yang Zhang

Automatically extracted metadata from scholarly documents in PDF formats is usually noisy and heterogeneous, often containing incomplete fields and erroneous values. One common way of cleaning metadata is to use a bibliographic reference…

Digital Libraries · Computer Science 2019-06-21 Athar Sefid , Jian Wu , Allen C. Ge , Jing Zhao , Lu Liu , Cornelia Caragea , Prasenjit Mitra , C. Lee Giles

Merging datasets is a key operation for data analytics. A frequent requirement for merging is joining across columns that have different surface forms for the same entity (e.g., the name of a person might be represented as "Douglas Adams"…

Machine Learning · Computer Science 2018-09-06 Kavitha Srinivas , Abraham Gale , Julian Dolby

The amount of image datasets collected for environmental monitoring purposes has increased in the past years as computer vision assisted methods have gained interest. Computer vision applications rely on high-quality datasets, making data…

Computer Vision and Pattern Recognition · Computer Science 2024-12-23 Mikko Impiö , Philipp M. Rehsen , Jenni Raitoharju

In optimization or machine learning problems we are given a set of items, usually points in some metric space, and the goal is to minimize or maximize an objective function over some space of candidate solutions. For example, in clustering…

Machine Learning · Computer Science 2020-11-19 Dan Feldman