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Genome-Wide Association Studies (GWAS) face unique challenges in the era of big genomics data, particularly when dealing with ultra-high-dimensional datasets where the number of genetic features significantly exceeds the available samples.…

Genomics · Quantitative Biology 2023-12-27 Kexuan Li

In practical domains, high-dimensional data are usually associated with diverse semantic labels, whereas traditional feature selection methods are designed for single-label data. Moreover, existing multi-label methods encounter two main…

Machine Learning · Computer Science 2025-05-26 Yan Zhong , Xingyu Wu , Xinping Zhao , Li Zhang , Xinyuan Song , Lei Shi , Bingbing Jiang

In many longitudinal microarray studies, the gene expression levels in a random sample are observed repeatedly over time under two or more conditions. The resulting time courses are generally very short, high-dimensional, and may have…

Applications · Statistics 2013-02-26 Maurice Berk , Cheryl Hemingway , Michael Levin , Giovanni Montana

In this paper, we present a new feature selection method that is suitable for both unsupervised and supervised problems. We build upon the recently proposed Infinite Feature Selection (IFS) method where feature subsets of all sizes…

Machine Learning · Computer Science 2017-08-22 Sadegh Eskandari , Emre Akbas

With the advent of extremely high dimensional datasets, dimensionality reduction techniques are becoming mandatory. Among many techniques, feature selection has been growing in interest as an important tool to identify relevant features on…

Feature selection with specific multivariate performance measures is the key to the success of many applications, such as image retrieval and text classification. The existing feature selection methods are usually designed for…

Machine Learning · Computer Science 2015-03-19 Qi Mao , Ivor W. Tsang

Cancer is fundamentally a genetic disease characterized by genetic and epigenetic alterations that disrupt normal gene expression, leading to uncontrolled cell growth and metastasis. High-dimensional microarray datasets pose challenges for…

Quantitative Methods · Quantitative Biology 2025-06-03 Sulaiman khan , Muhammad Ahmad , Fida Ullah , Carlos Aguilar Ibañez , José Eduardo Valdez Rodriguez

In genetic studies, not only can the number of predictors obtained from microarray measurements be extremely large, there can also be multiple response variables. Motivated by such a situation, we consider semiparametric dimension reduction…

Methodology · Statistics 2013-09-25 Heng Lian , Shujie Ma

Genetic algorithms are a widely used method in chemometrics for extracting variable subsets with high prediction power. Most fitness measures used by these genetic algorithms are based on the ordinary least-squares fit of the resulting…

Computation · Statistics 2017-11-21 David Kepplinger , Peter Filzmoser , Kurt Varmuza

Gene set analysis (GSA) is a foundational approach for interpreting genomic data of diseases by linking genes to biological processes. However, conventional GSA methods overlook clinical context of the analyses, often generating long lists…

We propose a new method for input variable selection in nonlinear regression. The method is embedded into a kernel regression machine that can model general nonlinear functions, not being a priori limited to additive models. This is the…

Machine Learning · Computer Science 2018-09-05 Magda Gregorová , Jason Ramapuram , Alexandros Kalousis , Stéphane Marchand-Maillet

Functional regression analysis is an established tool for many contemporary scientific applications. Regression problems involving large and complex data sets are ubiquitous, and feature selection is crucial for avoiding overfitting and…

Methodology · Statistics 2024-10-18 Tobia Boschi , Lorenzo Testa , Francesca Chiaromonte , Matthew Reimherr

One main obstacle for the wide use of deep learning in medical and engineering sciences is its interpretability. While neural network models are strong tools for making predictions, they often provide little information about which features…

Machine Learning · Statistics 2021-12-06 Vu Dinh , Lam Si Tung Ho

Data-efficient image classification is a challenging task that aims to solve image classification using small training data. Neural network-based deep learning methods are effective for image classification, but they typically require…

Neural and Evolutionary Computing · Computer Science 2022-12-05 Ying Bi , Bing Xue , Mengjie Zhang

Microarray gene expression data are often accompanied by a large number of genes and a small number of samples. However, only a few of these genes are relevant to cancer, resulting in signigicant gene selection challenges. Hence, we propose…

Machine Learning · Computer Science 2021-06-11 Xiongshi Deng , Min Li , Shaobo Deng , Lei Wang

For classification problems, feature extraction is a crucial process which aims to find a suitable data representation that increases the performance of the machine learning algorithm. According to the curse of dimensionality theorem, the…

Machine Learning · Computer Science 2010-10-12 Ilknur Icke , Andrew Rosenberg

Feature selection has always been a critical step in pattern recognition, in which evolutionary algorithms, such as the genetic algorithm (GA), are most commonly used. However, the individual encoding scheme used in various GAs would either…

Machine Learning · Computer Science 2017-05-01 Benteng Ma , Yong Xia

In this paper we examine the application of the random forest classifier for the all relevant feature selection problem. To this end we first examine two recently proposed all relevant feature selection algorithms, both being a random…

Artificial Intelligence · Computer Science 2011-06-28 Miron B. Kursa , Witold R. Rudnicki

Background: High-throughput proteomics techniques, such as mass spectrometry (MS)-based approaches, produce very high-dimensional data-sets. In a clinical setting one is often interested in how mass spectra differ between patients of…

Biological data including gene expression data are generally high-dimensional and require efficient, generalizable, and scalable machine-learning methods to discover their complex nonlinear patterns. The recent advances in machine learning…

Machine Learning · Computer Science 2020-12-21 Dinesh Singh , Héctor Climente-González , Mathis Petrovich , Eiryo Kawakami , Makoto Yamada