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Most clinical trials conducted in drug development contain multiple endpoints in order to collectively assess the intended effects of the drug on various disease characteristics. Focusing on the estimation of the global win probability,…

Methodology · Statistics 2024-04-09 Di Shu , Guangyong Zou

We consider a re-sampling scheme for estimation of the population parameters in the mixed effects nonlinear regression models of the type use for example in clinical pharmacokinetics, say. We provide an estimation procedure which {\it…

Statistics Theory · Mathematics 2019-02-05 Benzion Boukai , Yue Zhang

Considered a pair of random lifetimes whose dependence is described by a Time Transformed Exponential model, we provide analytical expressions for the distribution of their sum. These expressions are obtained by using a representation of…

Statistics Theory · Mathematics 2024-12-13 Jorge Navarro , Franco Pellerey , Julio Mulero

Sampling from circular distributions is a fundamental task in directional statistics. A key challenge in acceptance-rejection methods lies in selecting an efficient envelope density, as poor choices can lead to low acceptance rates and…

Methodology · Statistics 2025-06-17 Surojit Biswas , Buddhananda Banerjee

Traditional accelerated life test plans are typically based on optimizing the C-optimality for minimizing the variance of an interested quantile of the lifetime distribution. The traditional methods rely on some specified planning values…

Applications · Statistics 2018-12-04 Lu Lu , I-Chen Lee , Yili Hong

This article explores the estimation of unknown parameters and reliability characteristics under the assumption that the lifetimes of the testing units follow an Inverted Exponentiated Pareto (IEP) distribution. Here, both point and…

Statistics Theory · Mathematics 2025-01-22 Rajendranath Mondal , Aditi Kar Gangopadhyay , Raju Bhakta , Kousik Maiti

Computing partition functions, the normalizing constants of probability distributions, is often hard. Variants of importance sampling give unbiased estimates of a normalizer Z, however, unbiased estimates of the reciprocal 1/Z are harder to…

Machine Learning · Statistics 2017-03-14 Colin Wei , Iain Murray

Manufacturers are required to demonstrate products meet reliability targets. A typical way to achieve this is with reliability demonstration tests (RDTs), in which a number of products are put on test and the test is passed if a target…

Methodology · Statistics 2019-05-22 Kevin James Wilson , Malcolm Farrow

Rejection sampling is a technique for sampling from difficult distributions. However, its use is limited due to a high rejection rate. Common adaptive rejection sampling methods either work only for very specific distributions or without…

Machine Learning · Statistics 2026-04-27 Akram Erraqabi , Michal Valko , Alexandra Carpentier , Odalric-Ambrym Maillard

We propose a new approach for estimating the parameters of a probability distribution. It consists on combining two new methods of estimation. The first is based on the definition of a new distance measuring the difference between…

Methodology · Statistics 2008-12-30 Ahmed Guellil , Tewfik Kernane

We tackle the problem of trajectory planning in an environment comprised of a set of obstacles with uncertain time-varying locations. The uncertainties are modeled using widely accepted Gaussian distributions, resulting in a…

Systems and Control · Electrical Eng. & Systems 2021-08-16 Vasileios Lefkopoulos , Maryam Kamgarpour

There is a fast-growing literature on estimating optimal treatment rules directly by maximizing the expected outcome. In biomedical studies and operations applications, censored survival outcome is frequently observed, in which case the…

Methodology · Statistics 2026-03-12 Yifan Cui , Junyi Liu , Tao Shen , Zhengling Qi , Xi Chen

We present a conformal inference method for constructing lower prediction bounds for survival times from right-censored data, extending recent approaches designed for more restrictive type-I censoring scenarios. The proposed method imputes…

Methodology · Statistics 2025-05-26 Matteo Sesia , Vladimir Svetnik

In many applications, different populations are compared using data that are sampled in a biased manner. Under sampling biases, standard methods that estimate the difference between the population means yield unreliable inferences. Here we…

Statistics Theory · Mathematics 2019-11-12 Dave Zachariah , Petre Stoica

Time-to-event endpoints show an increasing popularity in phase II cancer trials. The standard statistical tool for such one-armed survival trials is the one-sample log-rank test. Its distributional properties are commonly derived in the…

Methodology · Statistics 2026-03-02 Moritz Fabian Danzer , Andreas Faldum , Rene Schmidt

In this paper a new distribution is proposed. This new model provides more flexibility to modeling data with upside-down bathtub hazard rate function. A significant account of mathematical properties of the new distribution is presented.…

Statistics Theory · Mathematics 2017-11-28 Pedro L. Ramos , Francisco Louzada , Taciana K. O. Shimizu , Aline O. Luiz

With the increasing availability of data from historical studies and real-world data sources, hybrid control designs that incorporate external data into the evaluation of current studies are being increasingly adopted. In these designs, it…

Methodology · Statistics 2025-06-23 Masahiro Kojima , Shunichiro Orihara , Keisuke Hanada , Tomohiro Ohigashi

The Unit Weibull distribution with parameters $\alpha$ and $\beta$ is considered to study in the context of dual generalized order statistics. For the analysis purpose, Bayes estimators based on symmetric and asymmetric loss functions are…

Methodology · Statistics 2025-02-06 Qazi J. Azhad , Abdul Nasir Khan , Bhagwati Devi , Jahangir Sabbir Khan , Ayush Tripathi

In the study of natural and artificial complex systems, responses that are not completely determined by the considered decision variables are commonly modelled probabilistically, resulting in response distributions varying across decision…

Methodology · Statistics 2021-10-07 Athénaïs Gautier , David Ginsbourger , Guillaume Pirot

. A sampling plan is a pilot tool for a supply and demand chain quality check strategy. These plans proved to be economically viable for the quality inspection processes but the uncertainty in the plan parameters challenged the reliability…

Systems and Control · Electrical Eng. & Systems 2023-02-06 Julia Thampy Thomas , Mahesh Kumar