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Deep generative models are increasingly becoming integral parts of the in silico molecule design pipeline and have dual goals of learning the chemical and structural features that render candidate molecules viable while also being flexible…

Biomolecules · Quantitative Biology 2021-06-08 Yair Schiff , Vijil Chenthamarakshan , Karthikeyan Natesan Ramamurthy , Payel Das

This paper presents a generative approach to speech enhancement based on a recurrent variational autoencoder (RVAE). The deep generative speech model is trained using clean speech signals only, and it is combined with a nonnegative matrix…

Machine Learning · Computer Science 2020-02-11 Simon Leglaive , Xavier Alameda-Pineda , Laurent Girin , Radu Horaud

Variational autoencoders (VAEs) and generative adversarial networks (GANs) enjoy an intuitive connection to manifold learning: in training the decoder/generator is optimized to approximate a homeomorphism between the data distribution and…

Machine Learning · Computer Science 2020-08-28 Henry Li , Ofir Lindenbaum , Xiuyuan Cheng , Alexander Cloninger

The work presented explores the use of denoising autoencoders (DAE) for brain lesion detection, segmentation and false positive reduction. Stacked denoising autoencoders (SDAE) were pre-trained using a large number of unlabeled patient…

Computer Vision and Pattern Recognition · Computer Science 2017-01-11 Varghese Alex , Kiran Vaidhya , Subramaniam Thirunavukkarasu , Chandrasekharan Kesavdas , Ganapathy Krishnamurthi

Variational Autoencoders (VAEs) typically rely on a probabilistic decoder with a predefined likelihood, most commonly an isotropic Gaussian, to model the data conditional on latent variables. While convenient for optimization, this choice…

Machine Learning · Statistics 2025-04-29 Chen Xu , Qiang Wang , Lijun Sun

Entropy is ubiquitous in machine learning, but it is in general intractable to compute the entropy of the distribution of an arbitrary continuous random variable. In this paper, we propose the amortized residual denoising autoencoder…

Machine Learning · Computer Science 2020-06-11 Jae Hyun Lim , Aaron Courville , Christopher Pal , Chin-Wei Huang

Variational Autoencoders are one of the most commonly used generative models, particularly for image data. A prominent difficulty in training VAEs is data that is supported on a lower-dimensional manifold. Recent work by Dai and Wipf (2020)…

Machine Learning · Computer Science 2022-05-19 Frederic Koehler , Viraj Mehta , Chenghui Zhou , Andrej Risteski

Autoencoders have seen wide success in domains ranging from feature selection to information retrieval. Despite this success, designing an autoencoder for a given task remains a challenging undertaking due to the lack of firm intuition on…

Neural and Evolutionary Computing · Computer Science 2020-04-17 Jeff Hajewski , Suely Oliveira , Xiaoyu Xing

Clustering using deep neural network models have been extensively studied in recent years. Among the most popular frameworks are the VAE and GAN frameworks, which learns latent feature representations of data through encoder / decoder…

Machine Learning · Computer Science 2021-05-14 Adam Lindhe , Carl Ringqvist , Henrik Hult

While unsupervised variational autoencoders (VAE) have become a powerful tool in neuroimage analysis, their application to supervised learning is under-explored. We aim to close this gap by proposing a unified probabilistic model for…

Machine Learning · Computer Science 2019-07-15 Qingyu Zhao , Ehsan Adeli , Nicolas Honnorat , Tuo Leng , Kilian M. Pohl

Variational autoencoders (VAEs) are a popular class of deep generative models with many variants and a wide range of applications. Improvements upon the standard VAE mostly focus on the modelling of the posterior distribution over the…

Machine Learning · Computer Science 2022-11-02 James Langley , Miguel Monteiro , Charles Jones , Nick Pawlowski , Ben Glocker

Deep generative models have been demonstrated as problematic in the unsupervised out-of-distribution (OOD) detection task, where they tend to assign higher likelihoods to OOD samples. Previous studies on this issue are usually not…

Machine Learning · Computer Science 2024-01-04 Zezhen Zeng , Bin Liu

Hypergraph data, which capture multi-way interactions among entities, are increasingly prevalent in the big data era. Generating new hyperlinks from an observed, usually high-dimensional hypergraph is an important yet challenging task with…

Methodology · Statistics 2026-05-14 Shihao Wu , Junyi Yang , Gongjun Xu , Ji Zhu

Unsupervised learning can leverage large-scale data sources without the need for annotations. In this context, deep learning-based auto encoders have shown great potential in detecting anomalies in medical images. However, state-of-the-art…

Machine Learning · Computer Science 2018-12-17 David Zimmerer , Simon A. A. Kohl , Jens Petersen , Fabian Isensee , Klaus H. Maier-Hein

Objective: This paper investigates how generative models, trained on ground-truth images, can be used \changes{as} priors for inverse problems, penalizing reconstructions far from images the generator can produce. The aim is that learned…

Image and Video Processing · Electrical Eng. & Systems 2023-08-07 Margaret Duff , Ivor J. A. Simpson , Matthias J. Ehrhardt , Neill D. F. Campbell

Problems such as predicting a new shading field (Y) for an image (X) are ambiguous: many very distinct solutions are good. Representing this ambiguity requires building a conditional model P(Y|X) of the prediction, conditioned on the image.…

Computer Vision and Pattern Recognition · Computer Science 2017-03-29 Jiajun Lu , Aditya Deshpande , David Forsyth

Recent advances in neural-based generative modeling have reignited the hopes of having computer systems capable of conversing with humans and able to understand natural language. The employment of deep neural architectures has been largely…

Computation and Language · Computer Science 2022-11-16 Haoqin Tu , Yitong Li

To address the challenges in learning deep generative models (e.g.,the blurriness of variational auto-encoder and the instability of training generative adversarial networks, we propose a novel deep generative model, named…

Machine Learning · Computer Science 2019-02-26 Shunkang Zhang , Yuan Gao , Yuling Jiao , Jin Liu , Yang Wang , Can Yang

Motivation: Despite advances in the computational analysis of high-throughput molecular profiling assays (e.g. transcriptomics), a dichotomy exists between methods that are simple and interpretable, and ones that are complex but with lower…

Machine Learning · Computer Science 2023-06-12 Pedro Henrique da Costa Avelar , Min Wu , Sophia Tsoka

In one-class novelty detection, a model learns solely on the in-class data to single out out-class instances. Autoencoder (AE) variants aim to compactly model the in-class data to reconstruct it exclusively, thus differentiating the…

Machine Learning · Computer Science 2022-07-25 Jaewoo Park , Yoon Gyo Jung , Andrew Beng Jin Teoh
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