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Physarum Polycephalum is a slime mold that can solve shortest path problems. A mathematical model based on Physarum's behavior, known as the Physarum Directed Dynamics, can solve positive linear programs. In this paper, we present a family…

Data Structures and Algorithms · Computer Science 2022-07-19 Yuan Gao , Hamidreza Kamkari , Andreas Karrenbauer , Kurt Mehlhorn , Mohammadamin Sharifi

We consider a system of nonlinear ordinary differential equations for the solution of linear programming (LP) problems that was first proposed in the mathematical biology literature as a model for the foraging behavior of acellular slime…

Optimization and Control · Mathematics 2021-03-30 Vincenzo Bonifaci

We present two results on slime mold computations. In wet-lab experiments (Nature'00) by Nakagaki et al. the slime mold Physarum polycephalum demonstrated its ability to solve shortest path problems. Biologists proposed a mathematical…

Data Structures and Algorithms · Computer Science 2019-07-01 Ruben Becker , Vincenzo Bonifaci , Andreas Karrenbauer , Pavel Kolev , Kurt Mehlhorn

Physarum Polycephalum is a slime mold that is apparently able to solve shortest path problems. A mathematical model has been proposed by biologists to describe the feedback mechanism used by the slime mold to adapt its tubular channels…

Data Structures and Algorithms · Computer Science 2019-07-01 Vincenzo Bonifaci , Kurt Mehlhorn , Girish Varma

Consider a learning algorithm, which involves an internal call to an optimization routine such as a generalized eigenvalue problem, a cone programming problem or even sorting. Integrating such a method as a layer(s) within a trainable deep…

Machine Learning · Computer Science 2021-05-11 Zihang Meng , Sathya N. Ravi , Vikas Singh

In the realm of biological flow networks, the ability to dynamically adjust to varying demands is paramount. Drawing inspiration from the remarkable adaptability of Physarum polycephalum, we present a novel physical mechanism tailored to…

Soft Condensed Matter · Physics 2023-10-05 Vidyesh Rao Anisetti , Ananth Kandala , J. M. Schwarz

A supply chain is a system which moves products from a supplier to customers. The supply chains are ubiquitous. They play a key role in all economic activities. Inspired by biological principles of nutrients' distribution in protoplasmic…

Neural and Evolutionary Computing · Computer Science 2014-03-24 Xiaoge Zhang , Andrew Adamatzky , Xin-She Yang , Hai Yang , Sankaran Mahadevan , Yong Deng

In this paper we present a connection between two dynamical systems arising in entirely different contexts: one in signal processing and the other in biology. The first is the famous Iteratively Reweighted Least Squares (IRLS) algorithm…

Data Structures and Algorithms · Computer Science 2016-01-13 Damian Straszak , Nisheeth K. Vishnoi

Optimization of fluid transport in the slime mold Physarum polycephalum has been the subject of several modeling efforts in recent literature. Existing models assume that the tube adaptation mechanism in P. polycephalum's tubular network is…

Tissues and Organs · Quantitative Biology 2019-07-01 Vincenzo Bonifaci

The slime mould Physarum polycephalum displays adaptive transport dynamics and network formation that have inspired its use as a model of biological computation. We develop a Lagrangian formulation of Physarum's adaptive dynamics on…

Neurons and Cognition · Quantitative Biology 2025-11-12 Ricard Solé , Jordi Pla-Mauri

In this work we study and expand a model describing the dynamics of a unicellular slime mold, Physarum Polycephalum (PP), which was proposed to simulate the ability of PP to find the shortest path connecting two food sources in a maze. The…

Numerical Analysis · Mathematics 2020-09-29 Enrico Facca , Franco Cardin , Mario Putti

The true slime mould Physarum polycephalum is a recent well studied example of how complex transport networks emerge from simple auto-catalytic and self- organising local interactions, adapting structure and function against changing…

Emerging Technologies · Computer Science 2015-03-29 Jeff Jones

Slime mould Physarum polycephalum is large single cell with intriguingly smart behaviour. The slime mould shows outstanding abilities to adapt its protoplasmic network to varying environmental conditions. The slime mould can solve tasks of…

Emerging Technologies · Computer Science 2013-04-09 Andrew Adamatzky , Rachel Armstrong , Jeff Jones , Yukio-Pegio Gunji

True slime mould Physarum polycephalum approximates a range of complex computations via growth and adaptation of its proto- plasmic transport network, stimulating a large body of recent research into how such a simple organism can perform…

Emerging Technologies · Computer Science 2015-03-12 Jeff Jones , Andrew Adamatzky

Decision-making is the process of selecting an action among alternatives, allowing biological and artificial systems to navigate complex environments and optimize behavior. While neural systems rely on neuron-based sensory processing and…

Biological Physics · Physics 2025-06-17 Lisa Schick , Emily Eichenlaub , Fabian Drexel , Alexander Mayer , Siyu Chen , Marcus Roper , Karen Alim

Physarum Polycephalum is a unicellular slime mold that has been intensely studied due to its ability to solve mazes, find shortest paths, generate Steiner trees, share knowledge, remember past events, and its applications to unconventional…

Biological Physics · Physics 2022-10-18 Sheryl Hsu , Laura P. Schaposnik

The giant single-celled slime mould Physarum polycephalum has inspired rapid develop- ments in unconventional computing substrates since the start of this century. This is primarily due to its simple component parts and the distributed…

Emerging Technologies · Computer Science 2015-11-19 Jeff Jones

Physarum polycephalum is an acellular slime mould that grows as a highly adaptive network of veins filled with protoplasm. As it forages, Physarum dynamically rearranges its network structure as a response to local stimuli information,…

Fluid Dynamics · Physics 2023-05-23 Rodrigo Almeida , Rui Dilão

The model organism Physarum polycephalum is known to perform decentralised problem solving despite absence of nervous system. Experimental evidence and modelling studies have linked these abilities, and in particular maze-solving, to some…

Biological Physics · Physics 2026-02-19 Daniele Proverbio , Giulia Giordano

Computing a polygon defining a set of planar points is a classical problem of modern computational geometry. In laboratory experiments we demonstrate that a concave hull, a connected alpha-shape without holes, of a finite planar set is…

Emerging Technologies · Computer Science 2012-06-26 Andrew Adamatzky
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