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Single molecule imaging is one of the main target areas of X-ray free electron lasers. It relies on the possibility of orienting the large number of low counting statistics 2D diffraction patterns taken at random orientations of identical…

Atomic and Molecular Clusters · Physics 2012-11-30 Zoltan Jurek , Gyula Faigel

Because of their high photon flux, X-ray free-electron lasers (FEL) allow to resolve the structure of individual nanoparticles via coherent diffractive imaging (CDI) within a single X-ray pulse. Since the inevitable rapid destruction of the…

X-ray fluorescence (XRF) enables element-specific, nondestructive imaging, but conventional raster scanning scales poorly with sample size, particularly for tomography, because measurements must be repeated at every projection angle and…

Optics · Physics 2026-04-14 A. Ben-Yehuda , A. Rack , S. Shwartz , N. Viganò

Single particle diffraction imaging experiments at free-electron lasers (FEL) have a great potential for structure determination of reproducible biological specimens that can not be crystallized. One of the challenges in processing the data…

Biological Physics · Physics 2013-10-16 O. M. Yefanov , I. A. Vartanyants

Diffraction imaging of non-equilibrium dynamics at atomic resolution is becoming possible with X-ray free-electron lasers. However, there are unresolved problems with applying this method to objects that are confined in only one dimension.…

Strongly Correlated Electrons · Physics 2018-02-19 Kenneth R. Beyerlein

Dynamical diffraction effects always play a role when working with perfect single crystals. The penetration of X-rays respect to the surface normal during diffraction (extinction depth, $1/\sigma_e$) in perfect single crystals does not have…

Instrumentation and Detectors · Physics 2021-01-20 Marcelo G. Honnicke , Sergio L. Morelhao

X-ray free-electron lasers (XFELs) offer unique capabilities for measuring the structure and dynamics of biomolecules, helping us understand the basic building blocks of life. Notably, high-repetition-rate XFELs enable single particle…

Computer Vision and Pattern Recognition · Computer Science 2023-12-25 Jay Shenoy , Axel Levy , Frédéric Poitevin , Gordon Wetzstein

Scattering experiments using ultrashort X-ray free electron laser (XFEL) pulses have opened a new path for structure determination of a wide variety of specimens, including nano-crystals and entire viruses, approaching atomistic spatial and…

Computational Physics · Physics 2026-04-17 Steffen Schultze , D. Russell Luke , Helmut Grubmüller

X-ray free electron lasers (X-FELs) present new opportunities to study ultrafast lattice dynamics in complex materials. While the unprecedented source brilliance enables high fidelity measurement of structural dynamics, it also raises…

Radiation damage is considered to be the major problem that still prevents imaging an individual biological molecule for structural analysis. So far, all known mapping techniques using sufficient short wave-length radiation, be it X-rays or…

Biological Physics · Physics 2010-10-28 Matthias Germann , Tatiana Latychevskaia , Conrad Escher , Hans-Werner Fink

A new scheme based on (i) upcoming brilliant X-ray Free Electron Laser (FEL) sources, (ii) novel energy and angular dispersive, large-area electron imagers and (iii) the well-known photoelectron holography is elaborated that provides…

Atomic Physics · Physics 2015-05-14 F. Krasniqi , B. Najjari , L. Strüder , D. Rolles , A. Voitkiv , J. Ullrich

Imaging with hard x-rays is an invaluable tool in medicine, biology, materials science, and cultural heritage. Propagation-based x-ray phase-contrast imaging and tomography have been mostly used to resolve micrometer-scale structures inside…

Image and Video Processing · Electrical Eng. & Systems 2025-06-02 Margie P. Olbinado , David M. Paganin , Yin Cheng , Alexander Rack

We study the perspectives of measuring the phenomenon of vacuum birefringence predicted by quantum electrodynamics using an x-ray free-electron laser (XFEL) alone. We devise an experimental scheme allowing the XFEL beam to collide with…

High Energy Physics - Phenomenology · Physics 2021-09-02 Felix Karbstein , Chantal Sundqvist , Kai S. Schulze , Ingo Uschmann , Holger Gies , Gerhard G. Paulus

With the rapid development of short-pulse intense laser sources, studies of matter under extreme irradiation conditions enter further unexplored regimes. In addition, an application of X-ray Free- Electron Lasers (XFELs), delivering intense…

We report an experimental proof of principle for ghost imaging in the hard x-ray energy range. We used a synchrotron x-ray beam that was split using a thin crystal in Laue diffraction geometry. With an ultra-fast imaging camera, we were…

In order to effectively improve the output quality of X-ray free electron laser (XFEL), we theoretically propose an XFEL scheme seeded by atomic inner-shell laser. As well known, an atomic inner-shell laser based on neutral atoms and pumped…

Accelerator Physics · Physics 2018-08-01 Han Zhang , Kai Li , Jiawei Yan , Haixiao Deng , Baoyuan Sun

An x-ray free-electron laser oscillator (XFELO) is a promising candidate for producing fully coherent x-rays beyond the fourth-generation light sources. An R&D XFELO experiment (ANL-SLAC-Spring-8 collaboration) to demonstrate the basic…

Accelerator Physics · Physics 2024-10-17 Peifan Liu , Kwang-Je Kim , Ryan Lindberg , Yuri Shvyd'ko

We describe statistical and coherence properties of the radiation from x-ray free electron lasers (XFEL). It is shown that the X-ray FEL radiation before saturation is described with gaussian statistics. Particularly important is the case…

Optics · Physics 2015-05-14 E. L. Saldin , E. A. Schneidmiller , M. V. Yurkov

Molecular and polymeric crystals show a wide range of functional properties that arise from the interplay between the atomic-scale structure of their constituent molecules and the organization of these molecules within the crystal lattice…