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We describe a scalable database cluster for the spatial analysis and annotation of high-throughput brain imaging data, initially for 3-d electron microscopy image stacks, but for time-series and multi-channel data as well. The system was…

We present a structural clustering algorithm for large-scale datasets of small labeled graphs, utilizing a frequent subgraph sampling strategy. A set of representatives provides an intuitive description of each cluster, supports the…

Databases · Computer Science 2016-10-03 Till Schäfer , Petra Mutzel

Clustering techniques are very attractive for extracting and identifying patterns in datasets. However, their application to very large spatial datasets presents numerous challenges such as high-dimensionality data, heterogeneity, and high…

Databases · Computer Science 2018-02-27 Malika Bendechache , Nhien-An Le-Khac , M-Tahar Kechadi

In this work, we revisit fast dimension reduction approaches, as with random projections and random sampling. Our goal is to summarize the data to decrease computational costs and memory footprint of subsequent analysis. Such dimension…

Machine Learning · Statistics 2018-03-20 Andrés Hoyos-Idrobo , Gaël Varoquaux , Jonas Kahn , Bertrand Thirion

Datasets in high-dimension do not typically form clusters in their original space; the issue is worse when the number of points in the dataset is small. We propose a low-computation method to find statistically significant clustering…

Machine Learning · Statistics 2020-08-24 Alden Bradford , Tarun Yellamraju , Mireille Boutin

We propose a method that combines signals from many brain regions observed in functional Magnetic Resonance Imaging (fMRI) to predict the subject's behavior during a scanning session. Such predictions suffer from the huge number of brain…

Computer Vision and Pattern Recognition · Computer Science 2011-04-29 Vincent Michel , Alexandre Gramfort , Gaël Varoquaux , Evelyn Eger , Christine Keribin , Bertrand Thirion

Clustering algorithms are one of the main analytical methods to detect patterns in unlabeled data. Existing clustering methods typically treat samples in a dataset as points in a metric space and compute distances to group together similar…

Machine Learning · Computer Science 2021-10-12 Tarek Naous , Srinjay Sarkar , Abubakar Abid , James Zou

Medical images used in clinical practice are heterogeneous and not the same quality as scans studied in academic research. Preprocessing breaks down in extreme cases when anatomy, artifacts, or imaging parameters are unusual or protocols…

Image and Video Processing · Electrical Eng. & Systems 2022-08-31 Mostafa Mehdipour Ghazi , Mads Nielsen

As more connectome data become available, the question of how to best analyse the structure of biological neural networks becomes increasingly pertinent. In brain networks, knowing that two areas are connected is often not sufficient, as…

Neurons and Cognition · Quantitative Biology 2024-01-30 Tanguy Fardet , Emmanouil Giannakakis , Lukas Paulun , Anna Levina

Clustering functional data is a challenging task due to intrinsic infinite-dimensionality and the need for stable, data-adaptive partitioning. In this work, we propose a clustering framework based on Random Projections, which simultaneously…

Methodology · Statistics 2025-12-18 Matteo Mori , Laura Anderlucci

Functional neuroimaging can measure the brain?s response to an external stimulus. It is used to perform brain mapping: identifying from these observations the brain regions involved. This problem can be cast into a linear supervised…

Machine Learning · Computer Science 2012-07-03 Gael Varoquaux , Alexandre Gramfort , Bertrand Thirion

We formulate a novel technique for the detection of functional clusters in discrete event data. The advantage of this algorithm is that no prior knowledge of the number of functional groups is needed, as our procedure progressively combines…

Neurons and Cognition · Quantitative Biology 2015-05-13 S. Feldt , J. Waddell , V. L. Hetrick , J. D. Berke , M. Zochowski

The problem of dimension reduction is of increasing importance in modern data analysis. In this paper, we consider modeling the collection of points in a high dimensional space as a union of low dimensional subspaces. In particular we…

Machine Learning · Statistics 2020-06-12 Weiwei Li , Jan Hannig , Sayan Mukherjee

Interactive visualization of embedding projections is a useful technique for understanding data and evaluating machine learning models. Labeling data within these visualizations is critical for interpretation, as labels provide an overview…

Human-Computer Interaction · Computer Science 2025-05-20 Donghao Ren , Fred Hohman , Dominik Moritz

As the data size in Machine Learning fields grows exponentially, it is inevitable to accelerate the computation by utilizing the ever-growing large number of available cores provided by high-performance computing hardware. However, existing…

Machine Learning · Computer Science 2021-04-23 Kun Li , Liang Yuan , Yunquan Zhang , Gongwei Chen

With rapidly increasing data, clustering algorithms are important tools for data analytics in modern research. They have been successfully applied to a wide range of domains; for instance, bioinformatics, speech recognition, and financial…

Data Structures and Algorithms · Computer Science 2015-12-01 Ka-Chun Wong

In this thesis, we present robust and fully-automated methods for the subdivision of the entire human cerebral cortex based on connectivity information. Our contributions are four-fold: First, we propose a clustering approach to delineate a…

Neurons and Cognition · Quantitative Biology 2018-02-21 Salim Arslan

We propose a novel methodology for feature screening in clustering massive datasets, in which both the number of features and the number of observations can potentially be very large. Taking advantage of a fusion penalization based convex…

Methodology · Statistics 2017-10-05 Trambak Banerjee , Gourab Mukherjee , Peter Radchenko

Current high-resolution imaging techniques require an intact sample that preserves spatial relationships. We here present a novel approach, "puzzle imaging," that allows imaging a spatially scrambled sample. This technique takes many…

Neurons and Cognition · Quantitative Biology 2016-02-17 Joshua I. Glaser , Bradley M. Zamft , George M. Church , Konrad P. Kording

We introduce a density-based clustering method called skeleton clustering that can detect clusters in multivariate and even high-dimensional data with irregular shapes. To bypass the curse of dimensionality, we propose surrogate density…

Machine Learning · Statistics 2023-03-09 Zeyu Wei , Yen-Chi Chen
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