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A major area in neuroscience research is the study of how the brain processes spatial information. Neurons in the brain represent external stimuli via neural codes. These codes often arise from stereotyped stimulus-response maps,…

Neurons and Cognition · Quantitative Biology 2016-10-03 Ethan Petersen , Nora Youngs , Ryan Kruse , Dane Miyata , Rebecca Garcia , Luis David Garcia Puente

In the brain, information is encoded, transmitted and used to inform behaviour at the level of timing of action potentials distributed over population of neurons. To implement neural-like systems in silico, to emulate neural function, and…

Neural and Evolutionary Computing · Computer Science 2022-12-09 Stefano Panzeri , Ella Janotte , Alejandro Pequeño-Zurro , Jacopo Bonato , Chiara Bartolozzi

A combinatorial code $\mathcal{C}$ is a collection of subsets of $[n]$, or equivalently a set of points in $\{0,1\}^n$. A morphism of codes is a map from one combinatorial code to another such that the coordinates of points in the image can…

Combinatorics · Mathematics 2026-03-12 Juliann Geraci , Alexander B. Kunin , Alexandra Seceleanu

Neurons in the brain represent information in their collective activity. The fidelity of this neural population code depends on whether and how variability in the response of one neuron is shared with other neurons. Two decades of studies…

Neurons and Cognition · Quantitative Biology 2021-02-02 Rava Azeredo da Silveira , Fred Rieke

Why do neurons encode information the way they do? Normative answers to this question model neural activity as the solution to an optimisation problem; for example, the celebrated efficient coding hypothesis frames neural activity as the…

Neurons and Cognition · Quantitative Biology 2026-03-06 William Dorrell , Peter E. Latham , James Whittington

How does the brain encode spatial structure? One way is through hippocampal neurons called place cells, which become associated to convex regions of space known as their receptive fields: each place cell fires at a high rate precisely when…

Neurons and Cognition · Quantitative Biology 2016-12-20 Caitlin Lienkaemper , Anne Shiu , Zev Woodstock

A neural code $\mathcal{C}$ is a collection of binary vectors of a given length n that record the co-firing patterns of a set of neurons. Our focus is on neural codes arising from place cells, neurons that respond to geographic stimulus. In…

Neurons and Cognition · Quantitative Biology 2016-07-05 Elizabeth Gross , Nida Kazi Obatake , Nora Youngs

A combinatorial neural code is a subset of the power set $2^{[n]}$ on $[n]=\{1,\dots, n\}$, in which each $1\leq i\leq n$ represents a neuron and each element (codeword) represents the co-firing event of some neurons. Consider a space…

Combinatorics · Mathematics 2025-12-05 R. Amzi Jeffs , Trong-Thuc Trang

It has been studied by Curto et al. (SIAM J. on App. Alg. and Geom., 1(1) : 222 $\unicode{x2013}$ 238, 2017) that a neural code that has an open convex realization does not have any local obstruction relative to the neural code. Further, a…

Algebraic Topology · Mathematics 2023-10-11 Neha Gupta , Suhith K N

A convex code is a binary code generated by the pattern of intersections of a collection of open convex sets in some Euclidean space. Convex codes are relevant to neuroscience as they arise from the activity of neurons that have convex…

Neurons and Cognition · Quantitative Biology 2018-07-10 Carina Curto , Elizabeth Gross , Jack Jeffries , Katherine Morrison , Zvi Rosen , Anne Shiu , Nora Youngs

This note is a brief survey of some results of the recent collaboration of neurobiologists and mathematicians dedicated to stimulus reconstruction from neuronal spiking activity. This collaboration, in particular, led to the consideration…

History and Overview · Mathematics 2015-01-06 Yuri I. Manin

Uniquely among primates, humans possess a remarkable capacity to recognize and manipulate abstract structure in the service of task goals across a broad range of behaviors. One illustration of this is in the visual perception of geometric…

Neurons and Cognition · Quantitative Biology 2023-10-02 Declan Campbell , Sreejan Kumar , Tyler Giallanza , Jonathan D. Cohen , Thomas L. Griffiths

In the intricate architecture of the mammalian central nervous system, neurons form populations. Axonal bundles communicate between these clusters using spike trains. However, these neuron populations' precise encoding and operations have…

Neurons and Cognition · Quantitative Biology 2024-01-02 Martin N. P. Nilsson

We introduce new geometric and combinatorial criteria that preclude a neural code from being convex, and use them to tackle the classification problem for codes on six neurons. Along the way, we give the first example of a code that is…

Combinatorics · Mathematics 2023-02-16 Laura Matusevich , Alexander Ruys de Perez , Anne Shiu

The neural rings and ideals as an algebraic tool for analyzing the intrinsic structure of neural codes were introduced by C.~Curto et al. in 2013. Since then they were investigated in several papers, including the 2017 paper by…

Commutative Algebra · Mathematics 2018-04-04 Katie Christensen , Hamid Kulosman

One major challenge of neuroscience is finding interesting structures in a seemingly disorganized neural activity. Often these structures have computational implications that help to understand the functional role of a particular brain…

Neurons and Cognition · Quantitative Biology 2023-09-01 Srdjan Ostojic , Stefano Fusi

Hippocampal neurons track positions of self, others, and gaze direction. However, it is unclear how their respective neural codes differ enough to avoid confusion while allowing for abstraction. We recorded from populations of hippocampal…

Place cells are neurons that act as biological position sensors, associated with and firing in response to regions of an environment to situate an organism in space. These associations are recorded in (combinatorial) neural codes,…

Combinatorics · Mathematics 2025-10-24 Saber Ahmed , Natasha Crepeau , Gisel Flores , Osiano Isekenegbe , Deanna Perez , Anne Shiu

Convex neural codes are combinatorial structures describing the intersection pattern of a collection of convex sets. Inductively pierced codes are a particularly nice subclass of neural codes introduced in the information visualization…

Combinatorics · Mathematics 2019-07-01 Caitlin Lienkaemper

Decoding approaches are widely used in neuroscience and machine learning to compare stimulus representations across neural systems, such as different brain regions, organisms, and deep learning models. Popular methods include decoding…

Neurons and Cognition · Quantitative Biology 2026-05-08 Johannes Bertram , Luciano Dyballa , T. Anderson Keller , Savik Kinger , Steven W. Zucker