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With an increasing amount of experimental evidence pouring in from neurobiological investigations, it is quite appropriate to study viable reductionist models which may explain some of the features of brain activities. It is now quite well…

Neurons and Cognition · Quantitative Biology 2007-05-23 Indranil Mitra , Sisir Roy

As a relatively new field, network neuroscience has tended to focus on aggregate behaviours of the brain averaged over many successive experiments or over long recordings in order to construct robust brain models. These models are limited…

Neurons and Cognition · Quantitative Biology 2022-05-19 James Wilsenach , Katie Warnaby , Charlotte M. Deane , Gesine Reinert

The non-Markovianity of the stochastic process called the quantum semi-Markov (QSM) process is studied using a recently proposed quantification of memory based on the deviation from semigroup evolution, that provides a unified description…

Quantum Physics · Physics 2022-02-07 Shrikant Utagi , Subhashish Banerjee , R. Srikanth

Characterizing the sleep-wake cycle in adolescents is an important prerequisite to better understand the association of abnormal sleep patterns with subsequent clinical and behavioral outcomes. The aim of this research was to develop hidden…

Applications · Statistics 2022-12-22 Semhar B. Ogbagaber , Yifan Cui , Kaigang Li , Ronald J. Iannotti , Paul S. Albert

The Hodgkin-Huxley model describes the conduction of the nervous impulse through the axon, whose membrane's electric response can be described employing multiple connected electric circuits containing capacitors, voltage sources, and…

Neurons and Cognition · Quantitative Biology 2021-12-13 Tasio Gonzalez-Raya , Enrique Solano , Mikel Sanz

Extending classical probabilistic reasoning using the quantum mechanical view of probability has been of recent interest, particularly in the development of hidden quantum Markov models (HQMMs) to model stochastic processes. However, there…

Machine Learning · Computer Science 2019-12-05 Sandesh Adhikary , Siddarth Srinivasan , Geoff Gordon , Byron Boots

Experiments on single ionic channels have contributed to a large extent to our current view on the function of cell membrane. In these experiments the main observables are the physical quantities: ionic concentration, membrane electrostatic…

Biological Physics · Physics 2018-04-17 Laureano Ramírez-Piscina , José M. Sancho

Ion channels are of major interest and form an area of intensive research in the fields of biophysics and medicine since they control many vital physiological functions. The aim of this work is on one hand to propose a fully stochastic and…

Biomolecules · Quantitative Biology 2016-01-11 Daniela Morale , Mattia Zanella , Vincenzo Capasso , Willi Jaeger

We propose and investigate a hidden Markov model (HMM) for the analysis of dependent, aggregated, superimposed two-state signal recordings. A major motivation for this work is that often these signals cannot be observed individually but…

In this paper we are interested to model quantum signal by statistical signal processing methods. The Gaussian distribution has been considered for the input quantum signal as Gaussian state have been proven to a type of important robust…

Quantum Physics · Physics 2023-02-17 Mouli Chakraborty , Harun Siljak , Indrakshi Dey , Nicola Marchetti

Traditionally, parameter estimation in biophysical neuron and neural network models usually adopts a global search algorithm, often combined with a local search method in order to minimize the value of a cost function, which measures the…

Quantitative Methods · Quantitative Biology 2012-03-05 Dimitrios V. Vavoulis , Volko A. Straub , John A. D. Aston , Jianfeng Feng

Recent studies have proposed that one can summarize brain activity into dynamics among a relatively small number of hidden states and that such an approach is a promising tool for revealing brain function. Hidden Markov models (HMMs) are a…

Neurons and Cognition · Quantitative Biology 2021-09-02 Takahiro Ezaki , Yu Himeno , Takamitsu Watanabe , Naoki Masuda

Using a stochastic generalization of the Hodgkin–Huxley model, we consider the influence of intrinsic channel noise on the synchronization between the spiking activity of the excitable membrane and an externally applied periodic…

Biological Physics · Physics 2007-05-23 Gerhard Schmid , Igor Goychuk , Peter Hanggi

This paper was presented in poster form at and in the proceedings of the QCMC 2008. It is a summary of a fuller paper to appear separately. The classical product state capacity of a noisy quantum channel with memory is investigated. A…

Quantum Physics · Physics 2012-08-16 I. Akhalwaya , J. Wouters , M. Fannes , F. Petruccione

Neural-network quantum states (NQS) employ artificial neural networks to encode many-body wave functions in second quantization through variational Monte Carlo (VMC). They have recently been applied to accurately describe electronic wave…

Chemical Physics · Physics 2023-11-27 Xiang Li , Jia-Cheng Huang , Guang-Ze Zhang , Hao-En Li , Chang-su Cao , Dingshun Lv , Han-Shi Hu

Markov state models (MSMs) have been successful in computing metastable states, slow relaxation timescales and associated structural changes, and stationary or kinetic experimental observables of complex molecules from large amounts of…

Chemical Physics · Physics 2015-06-17 Frank Noe , Hao Wu , Jan-Hendrik Prinz , Nuria Plattner

Hidden Markov models (HMM) are commonly used in generation tasks and have demonstrated strong capabilities in neuro-symbolic applications for the Markov property. These applications leverage the strengths of neural networks and symbolic…

Machine Learning · Computer Science 2025-10-01 Hanyuan Gao , Xiaoxuan Yang

Hidden Markov models (HMMs) are probabilistic methods in which observations are seen as realizations of a latent Markov process with discrete states that switch over time. Moving beyond standard statistical tests, HMMs offer a statistical…

Methodology · Statistics 2024-03-20 S. Mildiner Moraga , E. Aarts

Among the predictive hidden Markov models that describe a given stochastic process, the {\epsilon}-machine is strongly minimal in that it minimizes every R\'enyi-based memory measure. Quantum models can be smaller still. In contrast with…

Quantum Physics · Physics 2019-10-02 Samuel Loomis , James P. Crutchfield

Hidden Markov models (HMMs) are ubiquitous in time-series modelling, with applications ranging from chemical reaction modelling to speech recognition. These HMMs are often large, with high-dimensional memories. A recently-proposed…

Quantum Physics · Physics 2026-01-23 Rishi Sundar , Thomas Elliott