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One of the paramount challenges in neuroscience is to understand the dynamics of individual neurons and how they give rise to network dynamics when interconnected. Historically, researchers have resorted to graph theory, statistics, and…

Neurons and Cognition · Quantitative Biology 2019-02-08 Jean-Baptiste Bardin , Gard Spreemann , Kathryn Hess

Simultaneous recordings from many neurons hide important information and the connections characterizing the network remain generally undiscovered despite the progresses of statistical and machine learning techniques. Discerning the presence…

Applications · Statistics 2019-03-21 Pietro Verzelli , Laura Sacerdote

The application of network techniques to the analysis of neural data has greatly improved our ability to quantify and describe these rich interacting systems. Among many important contributions, networks have proven useful in identifying…

Quantitative Methods · Quantitative Biology 2018-06-14 Ann E. Sizemore , Jennifer Phillips-Cremins , Robert Ghrist , Danielle S. Bassett

In this article, we introduce a Topological Data Analysis (TDA) pipeline for neural spike train data. Understanding how the brain transforms sensory information into perception and behavior requires analyzing coordinated neural population…

Methodology · Statistics 2025-12-10 Cagatay Ayhan , Audrey N. Nash , Roberto Vincis , Martin Bauer , Richard Bertram , Tom Needham

Identification of patterns from discrete data time-series for statistical inference, threat detection, social opinion dynamics, brain activity prediction has received recent momentum. In addition to the huge data size, the associated…

Machine Learning · Computer Science 2019-02-22 Ruochen Yang , Gaurav Gupta , Paul Bogdan

Topological data analysis uses tools from topology -- the mathematical area that studies shapes -- to create representations of data. In particular, in persistent homology, one studies one-parameter families of spaces associated with data,…

Machine Learning · Computer Science 2020-12-01 Guido Montúfar , Nina Otter , Yuguang Wang

Link prediction is an important learning task for graph-structured data. In this paper, we propose a novel topological approach to characterize interactions between two nodes. Our topological feature, based on the extended persistent…

Machine Learning · Computer Science 2021-06-15 Zuoyu Yan , Tengfei Ma , Liangcai Gao , Zhi Tang , Chao Chen

Persistent homology, a technique from computational topology, has recently shown strong empirical performance in the context of graph classification. Being able to capture long range graph properties via higher-order topological features,…

Machine Learning · Computer Science 2024-12-20 Rubén Ballester , Bastian Rieck

We use topological data analysis to study neural population activity in the Sensorium 2023 dataset, which records responses from thousands of mouse visual cortex neurons to diverse video stimuli. For each video, we build frame-by-frame…

Algebraic Topology · Mathematics 2026-03-04 Yuri Gardinazzi , Alessio Ansuini , Eugenio Piasini , Fabio Anselmi , Matteo Biagetti

We use topological data analysis to study "functional networks" that we construct from time-series data from both experimental and synthetic sources. We use persistent homology with a weight rank clique filtration to gain insights into…

Quantitative Methods · Quantitative Biology 2017-05-24 Bernadette J. Stolz , Heather A. Harrington , Mason A. Porter

Persistent topological properties of an image serve as an additional descriptor providing an insight that might not be discovered by traditional neural networks. The existing research in this area focuses primarily on efficiently…

Computer Vision and Pattern Recognition · Computer Science 2023-03-07 Ekaterina Khramtsova , Guido Zuccon , Xi Wang , Mahsa Baktashmotlagh

We characterize structures such as monotonicity, convexity, and modality in smooth regression curves using persistent homology. Persistent homology is a key tool in topological data analysis that detects higher-dimensional topological…

Algebraic Topology · Mathematics 2025-10-28 Satish Kumar , Subhra Sankar Dhar

Topological data analysis and its main method, persistent homology, provide a toolkit for computing topological information of high-dimensional and noisy data sets. Kernels for one-parameter persistent homology have been established to…

Machine Learning · Computer Science 2019-06-06 René Corbet , Ulderico Fugacci , Michael Kerber , Claudia Landi , Bei Wang

Neurons in the central nervous system communicate with each other with the help of series of Action Potentials, or spike trains. Various studies have shown that neurons encode information in different features of spike trains, such as the…

Neurons and Cognition · Quantitative Biology 2014-10-21 Shubhanshu Shekhar , Kaushik Majumdar

Persistent homology is a topological data analysis tool that has been widely generalized, extending its scope beyond the field of topology. Among its extensions, steady and ranging persistence were developed to study a wide variety of graph…

Algebraic Topology · Mathematics 2026-05-15 Yann-Situ Gazull

We present a hidden Markov model that describes variation in an animal's position associated with varying levels of activity in action potential spike trains of individual place cell neurons. The model incorporates a coarse-graining of…

Applications · Statistics 2014-12-22 Marc Box , Matt W. Jones , Nick Whiteley

Although neural networks are capable of reaching astonishing performances on a wide variety of contexts, properly training networks on complicated tasks requires expertise and can be expensive from a computational perspective. In industrial…

Machine Learning · Statistics 2021-05-11 Théo Lacombe , Yuichi Ike , Mathieu Carriere , Frédéric Chazal , Marc Glisse , Yuhei Umeda

Recent years have witnessed an increased interest in the application of persistent homology, a topological tool for data analysis, to machine learning problems. Persistent homology is known for its ability to numerically characterize the…

Neural and Evolutionary Computing · Computer Science 2016-08-29 Jen-Yu Liu , Shyh-Kang Jeng , Yi-Hsuan Yang

Techniques from computational topology, in particular persistent homology, are becoming increasingly relevant for data analysis. Their stable metrics permit the use of many distance-based data analysis methods, such as multidimensional…

Algebraic Topology · Mathematics 2021-01-20 Bastian Rieck , Filip Sadlo , Heike Leitte

Detecting statistical interactions between input features is a crucial and challenging task. Recent advances demonstrate that it is possible to extract learned interactions from trained neural networks. It has also been observed that, in…

Machine Learning · Computer Science 2020-11-05 Zirui Liu , Qingquan Song , Kaixiong Zhou , Ting Hsiang Wang , Ying Shan , Xia Hu
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