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Cell detection in microscopy images is important to study how cells move and interact with their environment. Most recent deep learning-based methods for cell detection use convolutional neural networks (CNNs). However, inspired by the…

Image and Video Processing · Electrical Eng. & Systems 2022-06-15 Royden Wagner , Karl Rohr

We derive multiscale statistics for deconvolution in order to detect qualitative features of the unknown density. An important example covered within this framework is to test for local monotonicity on all scales simultaneously. We…

Statistics Theory · Mathematics 2015-03-19 Johannes Schmidt-Hieber , Axel Munk , Lutz Duembgen

Motivation: Tumor classification using Imaging Mass Spectrometry (IMS) data has a high potential for future applications in pathology. Due to the complexity and size of the data, automated feature extraction and classification steps are…

Machine Learning · Statistics 2018-06-28 Jens Behrmann , Christian Etmann , Tobias Boskamp , Rita Casadonte , Jörg Kriegsmann , Peter Maass

Recent advances have demonstrated the possibility of solving the deconvolution problem without prior knowledge of the noise distribution. In this paper, we study the repeated measurements model, where information is derived from multiple…

Statistics Theory · Mathematics 2024-09-04 Jérémie Capitao-Miniconi , Elisabeth Gassiat , Luc Lehéricy

Transceivers used for telecommunications transmit and receive specific modulation patterns that are represented as sequences of complex numbers. Classifying modulation patterns is challenging because noise and channel impairments affect the…

Machine Learning · Computer Science 2020-10-30 Jakob Krzyston , Rajib Bhattacharjea , Andrew Stark

Source separation or demixing is the process of extracting multiple components entangled within a signal. Contemporary signal processing presents a host of difficult source separation problems, from interference cancellation to background…

Information Theory · Computer Science 2015-06-17 Michael B. McCoy , Volkan Cevher , Quoc Tran Dinh , Afsaneh Asaei , Luca Baldassarre

Two blind source separation methods (Independent Component Analysis and Non-negative Matrix Factorization), developed initially for signal processing in engineering, found recently a number of applications in analysis of large-scale data in…

Quantitative Methods · Quantitative Biology 2015-02-03 Andrei Zinovyev , Ulykbek Kairov , Tatiana Karpenyuk , Erlan Ramanculov

Active nematics is an emerging paradigm for characterising biological systems. One aspect of particularly intense focus is the role active nematic defects play in these systems, as they have been found to mediate a growing number of…

Soft Condensed Matter · Physics 2024-01-25 Andrew Killeen , Thibault Bertrand , Chiu Fan Lee

The ability of detecting and separating CTCs can play a key role in early cancer detection and treatment. In recent years, there has been growing interest in using deformability-based CTC separation microfilters due to their simplicity and…

Cell Behavior · Quantitative Biology 2016-01-11 Mohammad Aghaamoo , Zhifeng Zhang , Xiaolin Chen , Jie Xu

Our work expands the use of capsule networks to the task of object segmentation for the first time in the literature. This is made possible via the introduction of locally-constrained routing and transformation matrix sharing, which reduces…

Image and Video Processing · Electrical Eng. & Systems 2020-12-14 Rodney LaLonde , Ziyue Xu , Ismail Irmakci , Sanjay Jain , Ulas Bagci

We propose a 3D convolutional neural network to simultaneously segment and detect cell nuclei in confocal microscopy images. Mirroring the co-dependency of these tasks, our proposed model consists of two serial components: the first part…

Image and Video Processing · Electrical Eng. & Systems 2018-09-07 Sundaresh Ram , Vicky T. Nguyen , Kirsten H. Limesand , Mert R. Sabuncu

Demixing is the problem of identifying multiple structured signals from a superimposed, undersampled, and noisy observation. This work analyzes a general framework, based on convex optimization, for solving demixing problems. When the…

Information Theory · Computer Science 2013-10-01 Michael B. McCoy , Joel A. Tropp

While deep learning has seen many recent applications to drug discovery, most have focused on predicting activity or toxicity directly from chemical structure. Phenotypic changes exhibited in cellular images are also indications of the…

Computer Vision and Pattern Recognition · Computer Science 2019-03-18 Philip T. Jackson , Yinhai Wang , Sinead Knight , Hongming Chen , Thierry Dorval , Martin Brown , Claus Bendtsen , Boguslaw Obara

In this paper, we incorporate a graph filter deconvolution step into the classical geometric convolutional neural network pipeline. More precisely, under the assumption that the graph domain plays a role in the generation of the observed…

Signal Processing · Electrical Eng. & Systems 2018-10-02 Jingkang Yang , Santiago Segarra

One-dimensional signal decomposition is a well-established and widely used technique across various scientific fields. It serves as a highly valuable pre-processing step for data analysis. While traditional decomposition techniques often…

Machine Learning · Computer Science 2025-06-09 Samuele Salti , Andrea Pinto , Alessandro Lanza , Serena Morigi

This work proposes an unsupervised fusion framework based on deep convolutional transform learning. The great learning ability of convolutional filters for data analysis is well acknowledged. The success of convolutive features owes to…

Machine Learning · Computer Science 2020-11-10 Pooja Gupta , Jyoti Maggu , Angshul Majumdar , Emilie Chouzenoux , Giovanni Chierchia

Advances in single-cell and spatial transcriptomic technologies have transformed tumor ecosystem profiling at cellular resolution. However, large scale studies on patient cohorts continue to rely on bulk transcriptomic data, where variation…

Machine Learning · Computer Science 2026-01-28 Zhiwei Zheng , Kevin Bryson

We present and analyse a model for cell signalling processes in biological tissues. The model includes diffusion and nonlinear reactions on the cell surfaces, and both inter- and intracellular signalling. Using techniques from the theory of…

Analysis of PDEs · Mathematics 2020-03-12 Mariya Ptashnyk , Chandrasekhar Venkataraman

We propose a class of estimators for deconvolution in mixture models based on a simple two-step "bin-and-smooth" procedure applied to histogram counts. The method is both statistically and computationally efficient: by exploiting recent…

Methodology · Statistics 2018-08-01 Oscar Hernan Madrid Padilla , Nicholas G. Polson , James G. Scott

Early detection of cancerous tissue is crucial for long-term patient survival. In the head and neck region, a typical diagnostic procedure is an endoscopic intervention where a medical expert manually assesses tissue using RGB camera…

Image and Video Processing · Electrical Eng. & Systems 2020-07-03 Marcel Bengs , Nils Gessert , Wiebke Laffers , Dennis Eggert , Stephan Westermann , Nina A. Mueller , Andreas O. H. Gerstner , Christian Betz , Alexander Schlaefer