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Engineering molecular systems that exhibit complex behavior requires the design of kinetic barriers. For example, an effective catalytic pathway must have a large barrier when the catalyst is absent. While programming such energy barriers…

Emerging Technologies · Computer Science 2020-01-28 Keenan Breik , Cameron Chalk , David Doty , David Haley , David Soloveichik

Exploring the free-energy landscape along reaction coordinates or system parameters $\lambda$ is central to many studies of high-dimensional model systems in physics, e.g. large molecules or spin glasses. In simulations this usually…

Statistical Mechanics · Physics 2018-09-05 Viveca Lindahl , Jack Lidmar , Berk Hess

Scalable and generalizable physics-aware deep learning has long been considered a significant challenge with various applications across diverse domains ranging from robotics to molecular dynamics. Central to almost all physical systems are…

Machine Learning · Computer Science 2026-02-04 Pranav Vaidhyanathan , Aristotelis Papatheodorou , Mark T. Mitchison , Natalia Ares , Ioannis Havoutis

We present a simple yet powerful framework for solving inverse problems by leveraging automatic differentiation. Our method is broadly applicable whenever a smooth cost function can be defined near the true solution, and a numerical…

Disordered Systems and Neural Networks · Physics 2025-06-17 Koji Kobayashi , Tomi Ohtsuki

We introduce a unified probabilistic framework for solving sequential decision making problems ranging from Bayesian optimisation to contextual bandits and reinforcement learning. This is accomplished by a probabilistic model-based approach…

A three-dimensional model of the far turbulent wake behind a self-propelled body in a passively stratified medium is considered. The model is reduced to a system of ordinary differential equations by a similarity reduction and the…

Mathematical Physics · Physics 2012-10-17 Oleg V. Kaptsov , Alexey V. Schmidt

Complex biological processes are usually experimented along time among a collection of individuals. Longitudinal data are then available and the statistical challenge is to better understand the underlying biological mechanisms. The…

Statistics Theory · Mathematics 2015-06-11 Pierre Barbillon , Célia Barthélémy , Adeline Samson

For quantum systems with competing potentials, the conventional perturbation theory often yields an asymptotic series and the subsequent numerical outcome becomes uncertain. To tackle such kind of problems, we develop a general solution…

Quantum Physics · Physics 2015-06-05 H. Mineo , Sheng D. Chao

We introduce multistate metadynamics for automatic exploration of conical intersection seams between adiabatic Born-Oppenheimer potential energy surfaces in molecular systems. By choosing the energy gap between the electronic states as a…

Chemical Physics · Physics 2018-05-10 Joachim O. Lindner , Merle I. S. Röhr , Roland Mitrić

Normal molecular dynamics simulations are usually unable to simulate chemical reactions due to the low probability of forming the transition state. Therefore, enhanced sampling methods are implemented to accelerate the occurrence of…

Chemical Physics · Physics 2022-10-14 Yi Sun , Xu Han , Lijiang Yang

Model Predictive Control (MPC) has proven to be a powerful tool for the control of systems with constraints. Nonetheless, in many applications, a major challenge arises, that is finding the optimal solution within a single sampling instant…

Systems and Control · Electrical Eng. & Systems 2023-08-16 Valentina Breschi , Simone Formentin , Alberto Leva

This paper presents a mechanically bistable mechanism of the compressed pre-curved beam. A governing equation is proposed which can be used to predict and explain the bistability of the compressed pre-curved beam. FE simulations and…

Applied Physics · Physics 2022-11-02 Fan Liu , Zian Jia , Xihang Jiang , Lifeng Wang

\textit{Reasoning} may be viewed as an algorithm $P$ that makes a choice of an action $a^* \in \mathcal{A}$, aiming to optimize some outcome. However, executing $P$ itself bears costs (time, energy, limited capacity, etc.) and needs to be…

Artificial Intelligence · Computer Science 2026-02-12 Prakhar Godara , Tilman Diego Alemán

Understanding the impact of extractant functionalization in solvent extraction is essential to guide the development of better separations processes. Traditionally, computational extractant design uses electronic structure calculations to…

Chemical Physics · Physics 2023-12-15 Xiaoyu Wang , Michael J. Servis

Metasurfaces are arrays of subwavelength meta-atoms that shape waves in a compact and planar form factor. Analysis and design of metasurfaces require methods for modeling their interactions with waves. Conventional modeling techniques…

Optics · Physics 2020-03-17 Mahsa Torfeh , Amir Arbabi

We consider the problem of simultaneous control and parameter estimation when the model is available only as a differentiable physics simulator. We propose a receding-horizon control framework in which a model predictive control (MPC)…

Optimization and Control · Mathematics 2026-04-07 Alan Williams , Alp Sunol

Properly modeling and predicting the scattering response of a metasurface is a particularly challenging task. This has been shown to be especially difficult if the metasurface supports both local and nonlocal interactions, in the form of…

Optics · Physics 2025-05-12 Hossein Allahverdizadeh , Karim Achouri

Model Predictive Control (MPC) in building energy management requires transient thermal models balancing thermodynamic accuracy with computational efficiency. Standard spatial discretization triggers state-space inflation, paralyzing…

Computational Engineering, Finance, and Science · Computer Science 2026-05-19 Corentin Guigot

We introduce a novel scheme for the mechanistic investigation of solid-solid phase transitions, which we dub \textit{metashooting}. Combining transition path sampling molecular dynamics and metadynamics, this scheme allows for both a…

Statistical Mechanics · Physics 2018-04-24 Samuel Alexander Jobbins , Salah Eddine Boulfelfel , Stefano Leoni

Differential equations are a ubiquitous tool to study dynamics, ranging from physical systems to complex systems, where a large number of agents interact through a graph with non-trivial topological features. Data-driven approximations of…

Statistical Mechanics · Physics 2024-04-26 Vaiva Vasiliauskaite , Nino Antulov-Fantulin