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Strongly coupled, recurrent, balanced network models have been successful in describing and predicting many phenomena observed in cortical neural recordings. However, most balanced network models use current-based synapse models in place of…
We consider a heterogeneous, globally coupled population of excitatory quadratic integrate-and-fire neurons with excitability adaptation due to a metabolic feedback associated with ketogenic diet, a form of therapy for epilepsy. Bifurcation…
A brain wide association study (BWAS) based on the logistic regression was first developed and applied to a large population of epilepsy patients (168) and healthy controls (136). It was found that the most significant links associated with…
Real-time coupling of cell cultures to neuromorphic circuits necessitates a neuromorphic network that replicates biological behaviour both on a per-neuron and on a population basis, with a network size comparable to the culture. We present…
In this chapter we review phenomenological models of seizure like activity. We discuss dynamical mechanisms for seizure onset and offset, preictal spikes, spike and wave complexes and status epilepticus, highlighting the role played by the…
Epileptic seizures are one of the most well-known dysfunctions of the nervous system. During a seizure, a highly synchronized behavior of neural activity is observed that can cause symptoms ranging from mild sensual malfunctions to the…
The mathematical model underlying the Neural Engineering Framework (NEF) expresses neuronal input as a linear combination of synaptic currents. However, in biology, synapses are not perfect current sources and are thus nonlinear. Detailed…
Temporal lobe epilepsy is one of the most common chronic neurological disorder characterized by the occurrence of spontaneous recurrent seizures which can be observed at the level of populations through electroencephalogram (EEG)…
The apparent stochasticity of in-vivo neural circuits has long been hypothesized to represent a signature of ongoing stochastic inference in the brain. More recently, a theoretical framework for neural sampling has been proposed, which…
We perform one and two-parameter numerical bifurcation analysis of a mechanotransduction model approximating the dynamics of mesenchymal stem cell differentiation into neurons, adipocytes, myocytes and osteoblasts. For our analysis, we use…
In real life, psychological and physiological states rarely change along a single dimension. Through self-tracking and discussions with clinicians, I have come to recognise with increasing clarity that sleep patterns, autonomic arousal,…
Inferring strength and direction of interactions from electroencephalographic (EEG) recordings is of crucial importance to improve our understanding of dynamical interdependencies underlying various physiologic and pathophysiologic…
Epilepsy is one of the most serious neurological diseases, affecting 1-2% of the world's population. The diagnosis of epilepsy depends heavily on the recognition of epileptic waves, i.e., disordered electrical brainwave activity in the…
Epilepsy is one of the most common neurological disorders globally, affecting millions of individuals. Despite significant advancements, the precise mechanisms underlying this condition remain largely unknown, making accurately predicting…
Neural oscillations are considered to be brain-specific signatures of information processing and communication in the brain. They also reflect pathological brain activity in neurological disorders, thus offering a basis for diagnoses and…
Epilepsy is a chronic neurological disorder with a significant prevalence. However, there is still no adequate technological support to enable epilepsy detection and continuous outpatient monitoring in everyday life. Hyperdimensional (HD)…
Epilepsy is a common neurological disorder characterized by abrupt seizures. Although seizures may appear random, they are often preceded by early warning signs in neural signals, notably, critical slowing down, a phenomenon in which the…
Epilepsy is a neurological disease characterized by recurrent and spontaneous seizures. It affects approximately 50 million people worldwide. In majority of the cases accurate diagnosis of the disease can be made without using any…
Epilepsy is a chronic neurological disorder affecting more than 50 million people globally. An epileptic seizure acts like a temporary shock to the neuronal system, disrupting normal electrical activity in the brain. Epilepsy is frequently…
Epilepsy is a neurological disorder arising from anomalies of the electrical activity in the brain, affecting about 0.5--0.8\% of the world population. Several studies investigated the relationship between seizures and brainwave…