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Molecular machines transduce free energy between different forms throughout all living organisms. While truly machines in their own right, unlike their macroscopic counterparts molecular machines are characterized by stochastic…

Statistical Mechanics · Physics 2025-06-13 Matthew P. Leighton , David A. Sivak

Nanoscale machines are strongly influenced by thermal fluctuations, contrary to their macroscopic counterparts. As a consequence, even the efficiency of such microscopic machines becomes a fluctuating random variable. Using geometric…

Statistical Mechanics · Physics 2019-04-16 Sreekanth K Manikandan , Lennart Dabelow , Ralf Eichhorn , Supriya Krishnamurthy

Molecular machines consist of either a single protein or a macromolecular complex composed of protein and RNA molecules. Just like their macroscopic counterparts, each of these nano-machines has an engine that "transduces" input energy into…

Biological Physics · Physics 2012-03-15 Debashish Chowdhury

In systems possessing spatial or dynamical symmetry breaking, Brownian motion combined with symmetric external input signals, deterministic or random, alike, can assist directed motion of particles at the submicron scales. In such cases,…

Statistical Mechanics · Physics 2009-06-05 Peter Hanggi , Fabio Marchesoni

The nanoscopic isothermal machines are not only energy but also information transducers. We show that the generalized fluctuation theorem with information creation and entropy reduction can be fulfilled for the enzymatic molecular machines…

Biological Physics · Physics 2017-02-06 Michal Kurzynski , Przemyslaw Chelminiak

Information processing machines at the nanoscales are unavoidably affected by thermal fluctuations. Efficient design requires understanding how nanomachines can operate at minimal energy dissipation. In this letter we focus on mechanical…

Statistical Mechanics · Physics 2015-03-17 Paolo Muratore-Ginanneschi , Kay Schwieger

Fluctuations strongly affect the dynamics and functionality of nanoscale thermal machines. Recent developments in stochastic thermodynamics have shown that fluctuations in many far-from-equilibrium systems are constrained by the rate of…

Quantum Physics · Physics 2021-01-29 Antoine Rignon-Bret , Giacomo Guarnieri , John Goold , Mark T. Mitchison

Biomolecular machines are protein complexes that convert between different forms of free energy. They are utilized in nature to accomplish many cellular tasks. As isothermal nonequilibrium stochastic objects at low Reynolds number, they…

Statistical Mechanics · Physics 2020-01-22 Aidan I Brown , David A Sivak

In systems possessing a spatial or dynamical symmetry breaking thermal Brownian motion combined with unbiased, non-equilibrium noise gives rise to a channelling of chance that can be used to exercise control over systems at the micro- and…

Statistical Mechanics · Physics 2009-11-10 P. Hänggi , F. Marchesoni , F. Nori

Thermodynamics of nanoscale devices is an active area of research. Despite their noisy surrounding they often produce mechanical work (e.g. micro-heat engines), display rectified Brownian motion (e.g. molecular motors). This invokes…

Statistical Mechanics · Physics 2018-12-05 Arnab Saha , Rahul Marathe , P. S. Pal , A. M. Jayannavar

Stochastic thermodynamics as reviewed here systematically provides a framework for extending the notions of classical thermodynamics like work, heat and entropy production to the level of individual trajectories of well-defined…

Statistical Mechanics · Physics 2015-06-05 Udo Seifert

Molecule- and solid-state gears build the elementary constituents of nanoscale mechanical machineries. Recent experimental advances in fabrication technologies in the field have strongly contributed to better delineate the roadmap towards…

Mesoscale and Nanoscale Physics · Physics 2022-05-10 Huang-Hsiang Lin , Alexander Croy , Rafael Gutierrez , Gianaurelio Cuniberti

When engineering microscopic machines, increasing efficiency can often come at a price of reduced reliability due to the impact of stochastic fluctuations. Here we develop a general method for performing multi-objective optimisation of…

Quantum Physics · Physics 2021-01-04 Harry J. D. Miller , Mohammad Mehboudi

Molecular motors are in charge of almost every process in the life cycle of cells, such as protein synthesis, DNA replication, and cell locomotion, hence being of crucial importance for understanding the cellular dynamics. However, given…

Statistical Mechanics · Physics 2025-09-05 Adrián Nadal-Rosa , Gonzalo Manzano

The aim of this book chapter is to indicate how quantum phenomena are affecting the operation of microscopic thermal machines, such as engines and refrigerators. As converting heat to work is one of the fundamental concerns in…

Quantum Physics · Physics 2019-05-01 Amikam Levy , David Gelbwaser-Klimovsky

Living things avoid equilibrium using molecular machines. Such microscopic soft-matter objects encounter relatively large friction and fluctuations. We discuss design principles for effective molecular machine operation in this unfamiliar…

Statistical Mechanics · Physics 2017-12-18 Aidan I Brown , David A Sivak

Biological functions in each animal cell depend on coordinated operations of a wide variety of molecular motors. Some of the these motors transport cargo to their respective destinations whereas some others are mobile workshops which…

Biological Physics · Physics 2008-03-07 Debashish Chowdhury

A Brownian Motor is a nanoscale or molecular device that combines the effects of thermal noise, spatial or temporal asymmetry, and directionless input energy to drive directed motion. Because of the input energy, Brownian motors function…

Statistical Mechanics · Physics 2009-11-13 R. Dean Astumian

Biological molecular machines are enzymes that simultaneously catalyze two processes, one donating free energy and second accepting it. Recent studies show that most native protein enzymes have a rich stochastic dynamics that often…

Biological Physics · Physics 2018-12-21 Michal Kurzynski , Przemyslaw Chelminiak

A molecular motor is made of either a single macromolecule or a macromolecular complex. Just like their macroscopic counterparts, molecular motors "transduce" input energy into mechanical work. All the nano-motors considered here operate…

Biological Physics · Physics 2013-07-18 Debashish Chowdhury
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