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Purpose: A novel approach using nano technology enhanced radiation modalities is investigated. The proposed methodology uses antibodies labeled with organically inert metals with a high atomic number. Irradiation using photons with energies…
Noble metal nanoparticles have been utilized for a vast amount of optical applications. For the applications that used metal nanoparticles as nanosensors and optical labeling, larger radiation damping is preferred (higher optical signal).…
Magnetic nanoparticles (MNPs) have been extensively used in drug/gene delivery, hyperthermia therapy, magnetic particle imaging (MPI), magnetic resonance imaging (MRI), magnetic bioassays, etc. With proper surface chemical modifications,…
We analyse mathematically the imaging modality using electromagnetic nanoparticles as contrast agent. This method uses the electromagnetic fields, collected before and after injecting electromagnetic nanoparticles, to reconstruct the…
The application of metal nanoparticles as sensitization materials is a common strategy that is used to study dose enhancement in radiotherapy. Recent in vitro tests have revealed that magnetic gold nanoparticles can be used in cancer…
Results of a Monte Carlo code intercomparison exercise for simulations of the dose enhancement from a gold nanoparticle (GNP) irradiated by X-rays have been recently reported. To highlight potential differences between codes, the dose…
Noble metal nanoparticles show specific optical properties due to the excitation of localized surface plasmons that make them attractive candidates for highly sensitive bionanosensors. The underlying physical principle is either an…
In this paper, we derive a variance-driven Local-Effect-Model ($\sigma$-LEM) to predict radiosensitization due to gold nanoparticles (AuNP). Assuming that the number of Au photo-ionisations scales strictly with particle volume…
In this paper we present new results on electronic emission of Gold Nanoparticles (GNPs) using X-ray photoelectron spectroscopy (XPS) and compare them to the gold bulk electron emission. This subject has undergone new interest within the…
: Understanding the correlations between magnetic nanoparticles is important for nanotechnologies, such as high-density magnetic recording and biomedical applications, where functionalized magnetic particles are used as contrast agents and…
We demonstrate the use of the magnetic-field-dependence of highly spatially confined, GHz-frequency ferromagnetic resonances in a ferromagnetic nanostructure for the detection of adsorbed magnetic nanoparticles. This is achieved in a large…
During the past years we have investigated the complexation between nanocolloids and oppositely charged polymers. The nanocolloids examined were ionic surfactant micelles and inorganic oxide nanoparticles. For the polymers, we used…
Gold nanoparticles have been conceived as a radiosensitizer in cancer radiation therapy, but one of the important questions for primary drug screening is what size of gold nanoparticles can optimally enhance radiation effects. Herein, we…
The pattern of radiation energy deposition in substances at the microscopic level of lattice, molecule size, or the cell's nucleus is not uniform. The energy of radiation is transferred to the substance medium in the form of discrete,…
This work investigates the change in cell survival predicted by the local effect model (LEM) for an irradiated cell containing metal nanoparticles (MNPs) depending on the distribution of neighboring cells and the uptake of MNPs into the…
Purpose: The introduction of Gold NanoParticles (GNPs) in radiotherapy requires consideration of GNP size, location, and quantity, and more, as well as beam quality. The work is presented in two parts, with Part I (this work) investigating…
Functionalized metal nanoparticles (NPs) have been proposed as promising radiosensitizing agents for more efficient radiotherapy treatment using photons and ion beams. Radiosensitizing properties of NPs may depend on many different…
Precise radiation delivery is critical for effective radiotherapy, and gold nanoparticles (AuNPs) have emerged as promising tools to enhance local dose deposition while sparing the surrounding healthy tissue. In this study, the PENELOPE…
In Monte Carlo particle transport codes, it is often important to adjust reaction cross sections to reduce the variance of calculations of relatively rare events, in a technique known as non-analogous Monte Carlo. We present the theory and…
We present a theoretical study of the radiative and nonradiative decay rates of an optical emitter in close proximity to a prolate-shaped metal nanoparticle. We use the model developed by Gersten and Nitzan, that we correct for radiative…