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At the last step of short read mapping, the candidate locations of the reads on the reference genome are verified to compute their differences from the corresponding reference segments using sequence alignment algorithms. Calculating the…

Genomics · Quantitative Biology 2024-07-04 Zülal Bingöl , Mohammed Alser , Onur Mutlu , Ozcan Ozturk , Can Alkan

Aligning millions of short DNA or RNA reads, of 75 to 250 base pairs each, to a reference genome is a significant computation problem in bioinformatics. We present a flexible and fast FPGA-based short read alignment tool. Our aligner makes…

Genomics · Quantitative Biology 2018-05-02 Nathaniel McVicar , Akina Hoshino , Anna La Torre , Thomas A. Reh , Walter L. Ruzzo , Scott Hauck

Genomic signal processing has been used successfully in bioinformatics to analyze biomolecular sequences and gain varied insights into DNA structure, gene organization, protein binding, sequence evolution, etc. But challenges remain in…

Genomics · Quantitative Biology 2022-11-04 Saish Jaiswal , Shreya Nema , Hema A Murthy , Manikandan Narayanan

Predicting future motions of road participants is an important task for driving autonomously. Most existing models excel at predicting the marginal trajectory of a single agent, but predicting joint trajectories for multiple agents that are…

Robotics · Computer Science 2024-11-26 Mingyi Wang , Hongqun Zou , Yifan Liu , You Wang , Guang Li

Motivation: Recent advances in sequencing technologies promise ultra-long reads of $\sim$100 kilo bases (kb) in average, full-length mRNA or cDNA reads in high throughput and genomic contigs over 100 mega bases (Mb) in length. Existing…

Genomics · Quantitative Biology 2018-09-17 Heng Li

Tools that effectively analyze and compare sequences are of great importance in various areas of applied computational research, especially in the framework of molecular biology. In the present paper, we introduce simple geometric criteria…

Quantitative Methods · Quantitative Biology 2013-08-14 Boris Brimkov , Valentin E. Brimkov

Genome sequence analysis plays a pivotal role in enabling many medical and scientific advancements in personalized medicine, outbreak tracing, and forensics. However, the analysis of genome sequencing data is currently bottlenecked by the…

Hardware Architecture · Computer Science 2021-11-04 Damla Senol Cali

Reconstructing the 3D model of a physical object typically requires us to align the depth scans obtained from different camera poses into the same coordinate system. Solutions to this global alignment problem usually proceed in two steps.…

Computer Vision and Pattern Recognition · Computer Science 2019-06-05 Xiangru Huang , Zhenxiao Liang , Xiaowei Zhou , Yao Xie , Leonidas Guibas , Qixing Huang

The challenging propagation environment, combined with the hardware limitations of mmWave systems, gives rise to the need for accurate initial access beam alignment strategies with low latency and high achievable beamforming gain. Much of…

Information Theory · Computer Science 2024-01-25 Daniel Tandler , Marc Gauger , Ahmet Serdar Tan , Sebastian Dörner , Stephan ten Brink

Frameshift mutations in protein-coding DNA sequences produce a drastic change in the resulting protein sequence, which prevents classic protein alignment methods from revealing the proteins' common origin. Moreover, when a large number of…

Quantitative Methods · Quantitative Biology 2011-01-18 Marta L. Gîrdea , Laurent Noé , Gregory Kucherov

Progressive acquisition of slowly-scanned images is desirable for drift correction and real-time visualization. Interlacing methods are common approaches to storing and transmitting data on rectilinear grids, and here we propose using them…

Other Condensed Matter · Physics 2022-12-08 Jacob D. Hinkle , Debangshu Mukherjee

Multiple mobile robots play a significant role in various spatially distributed tasks.In unfamiliar and non-repetitive scenarios, reconstructing the global map is time-inefficient and sometimes unrealistic. Hence, research has focused on…

Robotics · Computer Science 2025-12-29 Weining Lu , Qingquan Lin , Litong Meng , Chenxi Li , Bin Liang

Multiple kernel learning algorithms are proposed to combine kernels in order to obtain a better similarity measure or to integrate feature representations coming from different data sources. Most of the previous research on such methods is…

Machine Learning · Computer Science 2012-07-03 Mehmet Gonen

We interleave sampling based motion planning methods with pruning ideas from minimum spanning tree algorithms to develop a new approach for solving a Multi-Goal Path Finding (MGPF) problem in high dimensional spaces. The approach alternates…

Multiagent Systems · Computer Science 2022-05-11 Nikhil Chandak , Kenny Chour , Sivakumar Rathinam , R. Ravi

An ability to generalize unconstrained conditions such as severe occlusions and large pose variations remains a challenging goal to achieve in face alignment. In this paper, a multistage model based on deep neural networks is proposed which…

Computer Vision and Pattern Recognition · Computer Science 2020-02-05 Huabin Wang , Rui Cheng , Jian Zhou , Liang Tao , Hon Keung Kwan

Accurate segmentation of myocardial lesions from multi-sequence cardiac magnetic resonance imaging is essential for cardiac disease diagnosis and treatment planning. However, achieving optimal feature correspondence is challenging due to…

Image and Video Processing · Electrical Eng. & Systems 2025-07-17 Yifan Gao , Shaohao Rui , Haoyang Su , Jinyi Xiang , Lianming Wu , Xiaosong Wang

A key solution to temporal sentence grounding (TSG) exists in how to learn effective alignment between vision and language features extracted from an untrimmed video and a sentence description. Existing methods mainly leverage vanilla soft…

Computer Vision and Pattern Recognition · Computer Science 2021-09-15 Daizong Liu , Xiaoye Qu , Pan Zhou

Dendrograms are a way to represent evolutionary relationships between organisms. Nowadays, these are inferred based on the comparison of genes or protein sequences by taking into account their differences and similarities. The genetic…

Molecular Networks · Quantitative Biology 2019-09-09 Daniel Gamermann , Arnau Montagud , J. Alberto Conejero , Pedro Fernández de Córdoba , Javier F. Urchueguía

The composition of training data mixtures is critical for effectively training large language models (LLMs), as it directly impacts their performance on downstream tasks. Our goal is to identify an optimal data mixture to specialize an LLM…

Machine Learning · Computer Science 2024-10-04 Simin Fan , David Grangier , Pierre Ablin

Deep metric learning plays a key role in various machine learning tasks. Most of the previous works have been confined to sampling from a mini-batch, which cannot precisely characterize the global geometry of the embedding space. Although…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Yuehua Zhu , Muli Yang , Cheng Deng , Wei Liu
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