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This study investigates the application of surface-enhanced Raman spectroscopy (SERS) as a diagnostic tool for myasthenia gravis, a severe neuromuscular disorder characterized by muscle weakness and fatigue. Blood serum samples were…

Medical Physics · Physics 2025-01-22 I. Riabenko , S. Prokhorenko , E. Klimova , K. Beloshenko

Stimulated Raman scattering (SRS) is a powerful method for label-free imaging and spectroscopy of materials. Recent experiments have shown that quantum-enhanced Raman scattering can surpass the shot noise limit and improve the sensitivity…

Quantum Physics · Physics 2025-02-27 Frank Schlawin , Manuel Gessner

Surface-enhanced Raman spectroscopy (SERS) is enabled by local surface plasmon resonances (LSPRs) in metallic nanogaps. When SERS is excited by direct illumination of the nanogap, the background heating of lattice and electrons can prevent…

Mesoscale and Nanoscale Physics · Physics 2023-08-23 Shusen Liao , Yunxuan Zhu , Qian Ye , Stephen Sanders , Jiawei Yang , Alessandro Alabastri , Douglas Natelson

The last two decades have witnessed a dramatic growth of wearable sensor technology, mainly represented by flexible, stretchable, on-skin electronic sensors that provide rich information of the wearer's health conditions and surroundings. A…

Surface Enhanced Raman Spectroscopy (SERS) is a highly sensitive and selective technique that greatly enhances the signal of an analyte, compared with its signal from classical Raman Spectroscopy, due to its interaction with a substrates…

Materials Science · Physics 2025-10-20 Jan Komeda , Antonio Cammarata , Tomas Polcar

Chiral nanophotonic platforms provide a means of creating near fields with both enhanced asymmetric properties and intensities. They can be exploited for optical measurements that allow enantiomeric discrimination at detection levels…

Photo-Induced Enhanced Raman Spectroscopy (PIERS) is a new surface enhanced Raman spectroscopy (SERS) modality with an order-of-magnitude Raman signal enhancement of adsorbed analytes over that of typical SERS substrates. Despite the…

Materials Science · Physics 2021-06-01 Junzhi Ye , Rakesh Arul , Michel K. Nieuwoudt , Junzhe Dong , Wei Gao , M. Cather Simpson

Single-molecule surface enhanced Raman scattering (SM-SERS) is one of the vital applications of plasmonic nanoparticles. The SM-SERS sensitivity critically depends on plasmonic hot-spots created at the vicinity of such nanoparticles. In…

Innovation in biomaterials has brought both breakthroughs and new challenges in medicine, as implant materials have become increasingly multifunctional and complex. One of the greatest issues is the difficulty in assessing the temporal and…

The sensitivity of classical Raman spectroscopy methods, such as Coherent Anti-Stokes Raman spectroscopy (CARS) or Stimulated Raman spectroscopy (SRS), is ultimately limited by shot-noise from the stimulating fields. We present the complete…

Optics · Physics 2021-10-22 Yoad Michael , Leon Bello , Michael Rosenbluh , Avi Pe'er

Metallic nanoparticle-on-a-mirror (NPoM) cavities enable extreme field confinement in sub-nm gaps, leading to unrivaled performance for nonlinear processes such as surface-enhanced Raman scattering (SERS). So far, prevailing experimental…

To develop highly sensitive, stable and repeatable surface-enhanced Raman scattering (SERS) substrates is crucial for analytical detection, which is a challenge for traditional metallic structures. Herein, by taking advantage of the high…

A typical surface-enhanced Raman scattering (SERS) system relies on deeply subwavelength field localization in nanoscale plasmonic cavities to enhance both the excitation and emission of Raman-active molecules. Here, we demonstrate that a…

Quantum Physics · Physics 2025-05-27 Mikolaj K. Schmidt , Alexander A. High , Michael J. Steel

The principle and experimental realization of a novel Raman spectroscopic technique entitled stimulated Raman phase shift (SRPS) spectroscopy was demonstrated. This technique depends on the measurement of the stimulated Raman scattering…

Optics · Physics 2024-03-07 Meng Qi , Wenrong Wang , Yuan-ji Li , Jin-xia Feng , Kuan-shou Zhang

Stimulated Raman scattering (SRS) microscopy allows for high-speed label-free chemical imaging of biomedical systems. The imaging sensitivity of SRS microscopy is limited to ~10 mM for endogenous biomolecules. Electronic pre-resonant SRS…

We present a general framework for inverse design of nanopatterned surfaces that maximize spatially averaged surface-enhanced Raman (SERS) spectra from molecules distributed randomly throughout a material or fluid, building upon a recently…

Surface enhanced Raman spectroscopy (SERS) is a precise and non-invasive analytical technique that is widely used in chemical analysis, environmental protection, food processing, pharmaceutics, and diagnostic biology. However, it is still a…

We present an in-depth analysis of the experimental estimation of cross sections in Surface Enhanced Raman Scattering (SERS) by vibrational pumping. The paper highlights the advantages and disadvantages of the technique, pinpoints the main…

Chemical Physics · Physics 2007-05-23 R. C. Maher , L. F. Cohen , E. C. Le Ru , P. G. Etchegoin

In this study, we combined the surface-enhanced Raman scattering (SERS) with density functional theory (DFT) calculations to investigate the SERS spectra of lanthanide (Ln)-citrate complexes (Ln = La, Ce, Pr, Nd, Sm, Eu, and Gd) under 488,…

Chemical Physics · Physics 2025-03-25 Hao Jin , Tamitake Itoh , Yuko S. Yamamoto

We report on efficient surface-enhanced Raman spectroscopy (SERS) supporting substrates, which are based on DNA-assisted lithography (DALI) and a layered configuration of materials. In detail, we used nanoscopic DNA origami bowtie templates…

Materials Science · Physics 2023-04-25 Kabusure M. Kabusure , Petteri Piskunen , Jiaqi Yang , Veikko Linko , Tommi K. Hakala