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Biochemical signaling cascades transmit intracellular information while dissipating energy under nonequilibrium conditions. We model a cascade as a code string and apply information-entropy ideas to quantify an optimal transmission rate. A…

Molecular Networks · Quantitative Biology 2026-01-21 Tatsuaki Tsuruyama

Many cells use calcium signalling to carry information from the extracellular side of the plasma membrane to targets in their interior. Since virtually all cells employ a network of biochemical reactions for Ca2+ signalling, much effort has…

Neurons and Cognition · Quantitative Biology 2009-12-17 Maurizio De Pitta` , Vladislav Volman , Herbert Levine , Eshel Ben-Jacob

Many cellular components are present in such low numbers that individual stochastic production and degradation events lead to significant fluctuations in molecular abundances. Although feedback control can, in principle, suppress such…

Molecular Networks · Quantitative Biology 2025-12-25 Ryan Ripsman , Brayden Kell , Andreas Hilfinger

Currently, biological signaling is envisaged as a combination of activation and movement, triggered by local molecular interactions and molecular diffusion, respectively. However, we here suggest, that other fundamental physical mechanisms…

Biological Physics · Physics 2018-05-22 B. Fichtl , I. Silman , M. F. Schneider

Biological systems are known to communicate by diffusing chemical signals in the surrounding medium. However, most of the recent literature has neglected the electron transfer mechanism occurring amongst living cells, and its role in…

Emerging Technologies · Computer Science 2015-02-23 Nicolo Michelusi , Sahand Pirbadian , Mohamed Y. El-Naggar , Urbashi Mitra

Many biological systems dynamically rearrange their components through a sequence of configurations in order to perform their functions. Such dynamic processes have been studied using network models that sequentially retrieve a set of…

Statistical Mechanics · Physics 2022-12-01 Lukas Herron , Pablo Sartori , BingKan Xue

Signaling in enzymatic networks is typically triggered by environmental fluctuations, resulting in a series of stochastic chemical reactions, leading to corruption of the signal by noise. For example, information flow is initiated by…

Statistical Mechanics · Physics 2017-07-19 Himadri S. Samanta , Michael Hinczewski , D. Thirumalai

We explore the critical behaviors in the dynamics of information transfer of a biologically-inspired system by an individual-based model. "Quorum response", a type of social interaction which has been recognized taxonomically in animal…

Physics and Society · Physics 2013-08-22 Collin Feng Hu

Measures of information transfer have become a popular approach to analyze interactions in complex systems such as the Earth or the human brain from measured time series. Recent work has focused on causal definitions of information transfer…

Methodology · Statistics 2016-03-21 Jakob Runge

This paper addresses the decomposition of biochemical networks into functional modules that preserve their dynamic properties upon interconnection with other modules, which permits the inference of network behavior from the properties of…

Molecular Networks · Quantitative Biology 2014-12-03 Hari Sivakumar , Stephen R. Proulx , João P. Hespanha

We study an information engine operating in an active bath, where a Brownian particle confined in a harmonic trap undergoes feedback-driven displacement cycles. Unlike thermal environments, active baths exhibit temporally correlated…

Statistical Mechanics · Physics 2025-11-27 Sehoon Bahng , Jae Sung Lee , Cheol-Min Ghim

Cells are constantly exposed to fluctuating environmental conditions. External signals are sensed, processed and integrated by cellular signal transduction networks, which translate input signals into specific cellular responses by means of…

Molecular Networks · Quantitative Biology 2012-05-29 Pau Rué , Núria Domedel-Puig , Jordi Garcia-Ojalvo , Antonio J. Pons

In a diffusion-based molecular communication system, molecules are employed to convey information. When propagation and reception processes are considered in a framework of first passage processes, we need to focus on absorbing receivers.…

Emerging Technologies · Computer Science 2016-09-05 H. Birkan Yilmaz , Gee-Yong Suk , Chan-Byoung Chae

We discuss the problem of the information transfer (exchange of states configuration) between two interacting quantum systems along their evolution in time. We consider the specific case of two modes of the electromagnetic field with…

Quantum Physics · Physics 2009-10-31 M. C. de Oliveira , S. S. Mizrahi , V. V. Dodonov

Neural oscillations are universal phenomena and can be observed at different levels of neural systems, from single neuron to macroscopic brain. The frequency of those oscillations are related to the brain functions. However, little is know…

Neurons and Cognition · Quantitative Biology 2015-07-30 Lianchun Yu , Longfei Wang , Fei Jia , Duojie Jia

In biological cells and novel diagnostic devices biochemical receptors need to be sensitive to extremely small concentration changes of signaling molecules. The accuracy of such molecular signaling is ultimately limited by the counting…

Subcellular Processes · Quantitative Biology 2023-04-06 Aljaz Godec , Ralf Metzler

We study the signal percolation through heart-like biological system. Starting from an initial distribution of waiting and inactive cells with probabilities $p$ and $(1-p)$ respectively, the signal propagation is observed in terms of active…

Statistical Mechanics · Physics 2024-07-12 Md Aquib Molla , Sanchari Goswami

Talkative power conversion is a switching ripple communication technique that integrates data modulation into a switched-mode power electronics converter, enabling simultaneous information transmission and power conversion. Despite numerous…

Systems and Control · Electrical Eng. & Systems 2025-04-17 Jan Mietzner , Cerikh Chakraborty , Peter A. Hoeher , Lutz Lampe

In many real-world systems, information can be transmitted in two qualitatively different ways: by copying or by transformation. Copying occurs when messages are transmitted without modification, e.g., when an offspring receives an…

Information Theory · Computer Science 2022-11-22 Artemy Kolchinsky , Bernat Corominas-Murtra

Exchange of molecules allows cells to exchange information. How robust is the information to changes in cell parameters? We use a mapping between the stochastic dynamics of two cells sharing a stimulatory molecule, and parameters akin to an…

Biological Physics · Physics 2024-07-10 Ismail Qunbar , Michael Vennettilli , Amir Erez
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