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Neural codes serve as a language for neurons in the brain. Convex codes, which arise from the pattern of intersections of convex sets in Euclidean space, are of particular relevance to neuroscience. Not every code is convex, however, and…

Combinatorics · Mathematics 2017-05-31 Joshua Cruz , Chad Giusti , Vladimir Itskov , Bill Kronholm

Neural codes, represented as collections of binary strings called codewords, are used to encode neural activity. A code is called convex if its codewords are represented as an arrangement of convex open sets in Euclidean space. Previous…

Combinatorics · Mathematics 2022-08-10 Katherine Johnston , Anne Shiu , Clare Spinner

The brain encodes spacial structure through a combinatorial code of neural activity. Experiments suggest such codes correspond to convex areas of the subject's environment. We present an intrinsic condition that implies a neural code may…

Combinatorics · Mathematics 2016-10-20 Robert Williams

Neural codes, represented as collections of binary strings, encode neural activity and show relationships among stimuli. Certain neurons, called place cells, have been shown experimentally to fire in convex regions in space. A natural…

Neurons and Cognition · Quantitative Biology 2019-09-20 Sarah Ayman Goldrup , Kaitlyn Phillipson

How does the brain encode spatial structure? One way is through hippocampal neurons called place cells, which become associated to convex regions of space known as their receptive fields: each place cell fires at a high rate precisely when…

Neurons and Cognition · Quantitative Biology 2016-12-20 Caitlin Lienkaemper , Anne Shiu , Zev Woodstock

A convex code is a binary code generated by the pattern of intersections of a collection of open convex sets in some Euclidean space. Convex codes are relevant to neuroscience as they arise from the activity of neurons that have convex…

Neurons and Cognition · Quantitative Biology 2018-07-10 Carina Curto , Elizabeth Gross , Jack Jeffries , Katherine Morrison , Zvi Rosen , Anne Shiu , Nora Youngs

Given an intersection pattern of arbitrary sets in Euclidean space, is there an arrangement of convex open sets in Euclidean space that exhibits the same intersections? This question is combinatorial and topological in nature, but is…

Combinatorics · Mathematics 2019-02-22 Aaron Chen , Florian Frick , Anne Shiu

Neural codes are collections of binary strings motivated by patterns of neural activity. In this paper, we study algorithmic and enumerative aspects of convex neural codes in dimension 1 (i.e. on a line or a circle). We use the theory of…

Combinatorics · Mathematics 2017-02-23 Zvi Rosen , Yan X. Zhang

Place cells are neurons that act as biological position sensors, associated with and firing in response to regions of an environment to situate an organism in space. These associations are recorded in (combinatorial) neural codes,…

Combinatorics · Mathematics 2025-10-24 Saber Ahmed , Natasha Crepeau , Gisel Flores , Osiano Isekenegbe , Deanna Perez , Anne Shiu

Determining how the brain stores information is one of the most pressing problems in neuroscience. In many instances, the collection of stimuli for a given neuron can be modeled by a convex set in $\mathbb{R}^d$. Combinatorial objects known…

Combinatorics · Mathematics 2019-05-29 R. Amzi Jeffs , Mohamed Omar , Natchanon Suaysom , Aleina Wachtel , Nora Youngs

Neural codes are lists of subsets of neurons that fire together. Of particular interest are neurons called place cells, which fire when an animal is in specific, usually convex regions in space. A fundamental question, therefore, is to…

Combinatorics · Mathematics 2021-04-05 Brianna Gambacini , R. Amzi Jeffs , Sam Macdonald , Anne Shiu

Convex neural codes are subsets of the Boolean lattice that record the intersection patterns of convex sets in Euclidean space. Much work in recent years has focused on finding combinatorial criteria on codes that can be used to classify…

Combinatorics · Mathematics 2020-12-18 R. Amzi Jeffs , Caitlin Lienkaemper , Nora Youngs

A combinatorial neural code is a subset of the power set $2^{[n]}$ on $[n]=\{1,\dots, n\}$, in which each $1\leq i\leq n$ represents a neuron and each element (codeword) represents the co-firing event of some neurons. Consider a space…

Combinatorics · Mathematics 2025-12-05 R. Amzi Jeffs , Trong-Thuc Trang

Much work has been done to identify which binary codes can be represented by collections of open convex or closed convex sets. While not all binary codes can be realized by such sets, here we prove that every binary code can be realized by…

Combinatorics · Mathematics 2018-04-30 Megan K. Franke , Samuel Muthiah

Neural codes are binary codes that are used for information processing and representation in the brain. In previous work, we have shown how an algebraic structure, called the {\it neural ring}, can be used to efficiently encode geometric…

Neurons and Cognition · Quantitative Biology 2019-02-14 Carina Curto , Nora Youngs

Why do neurons encode information the way they do? Normative answers to this question model neural activity as the solution to an optimisation problem; for example, the celebrated efficient coding hypothesis frames neural activity as the…

Neurons and Cognition · Quantitative Biology 2026-03-06 William Dorrell , Peter E. Latham , James Whittington

We introduce new geometric and combinatorial criteria that preclude a neural code from being convex, and use them to tackle the classification problem for codes on six neurons. Along the way, we give the first example of a code that is…

Combinatorics · Mathematics 2023-02-16 Laura Matusevich , Alexander Ruys de Perez , Anne Shiu

Previous work on convexity of neural codes has produced codes that are open-convex but not closed-convex -- or vice-versa. However, why a code is one but not the other, and how to detect such discrepancies are open questions. We tackle…

Combinatorics · Mathematics 2022-08-30 Patrick Chan , Katherine Johnston , Joseph Lent , Alexander Ruys de Perez , Anne Shiu

The central problem with understanding brain and mind is the neural code issue: understanding the matter of our brain as basis for the phenomena of our mind. The richness with which our mind represents our environment, the parsimony of…

Neurons and Cognition · Quantitative Biology 2018-11-06 Christoph von der Malsburg

Networks of neurons in the brain encode preferred patterns of neural activity via their synaptic connections. Despite receiving considerable attention, the precise relationship between network connectivity and encoded patterns is still…

Neurons and Cognition · Quantitative Biology 2015-02-25 Carina Curto , Anda Degeratu , Vladimir Itskov
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