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Consider the problem of constructing an experimental design, optimal for estimating parameters of a given statistical model with respect to a chosen criterion. To address this problem, the literature usually provides a single solution.…

Computation · Statistics 2024-11-05 Radoslav Harman , Lenka Filová , Samuel Rosa

We introduce a Geometry of Interaction model for higher-order quantum computation, and prove its adequacy for a full quantum programming language in which entanglement, duplication, and recursion are all available. Our model comes with a…

Logic in Computer Science · Computer Science 2017-07-18 Ugo Dal Lago , Claudia Faggian , Benoit Valiron , Akira Yoshimizu

We consider design issues for toxicology studies when we have a continuous response and the true mean response is only known to be a member of a class of nested models. This class of non-linear models was proposed by toxicologists who were…

Statistics Theory · Mathematics 2010-11-29 Holger Dette , Andrey Pepelyshev , Piter Shpilev , Weng Kee Wong

The problem of constructing optimal discriminating designs for a class of regression models is considered. We investigate a version of the $T_p$-optimality criterion as introduced by Atkinson and Fedorov [Biometrika 62 (1975a) 289-303]. The…

Statistics Theory · Mathematics 2013-06-07 Dietrich Braess , Holger Dette

$E$-optimal experimental designs for a second-order response surface model with $k\geq1$ predictors are investigated. If the design space is the $k$-dimensional unit cube, Galil and Kiefer [J. Statist. Plann. Inference 1 (1977a) 121-132]…

Methodology · Statistics 2014-09-01 Holger Dette , Yuri Grigoriev

In real life situations often paired comparisons involving alternatives of either full or partial profiles to mitigate cognitive burden are presented. For this situation the problem of finding optimal designs is considered in the presence…

Methodology · Statistics 2021-10-20 Eric Nyarko

We consider an optimal semiconductor design problem for the quantum drift diffusion (QDD) model in the semiclassical limit. The design question is formulated as a PDE constrained optimal control problem, where the doping profile acts as…

Optimization and Control · Mathematics 2015-01-19 René Pinnau , Sebastian Rau , Florian Schneider , Oliver Tse

Two-level factorial designs are widely used in industrial experiments. For processes involving \(n\) factors, the construction of designs comprising \(2^n\) and \(2^{n-p}\) factorials, arranged in blocks of size \(2^q\) is investigated. The…

Statistics Theory · Mathematics 2019-07-05 Janet Godolphin

In most real-world systems units are interconnected and can be represented as networks consisting of nodes and edges. For instance, in social systems individuals can have social ties, family or financial relationships. In settings where…

Methodology · Statistics 2018-07-31 Laura Forastiere , Fabrizia Mealli , Albert Wu , Edoardo Airoldi

Dynamical systems are frequently used to model biological systems. When these models are fit to data it is necessary to ascertain the uncertainty in the model fit. Here we present prediction deviation, a new metric of uncertainty that…

Applications · Statistics 2017-06-08 Benjamin Letham , Portia A. Letham , Cynthia Rudin , Edward P. Browne

Linear response theory has found many applications in statistical physics. One of these is to compute minimal-work protocols that drive nonequilibrium systems between different thermodynamic states, which are useful for designing engineered…

Statistical Mechanics · Physics 2026-01-19 Samuel. H. DAmbrosia , Adrianne Zhong , Michael R. DeWeese

A statistician designing an experiment wants to get as much information as possible from the data gathered. Often this means the most precise estimate possible (that is, an estimate with minimum possible variance) of the unknown parameters.…

Statistics Theory · Mathematics 2011-11-17 R. A. Bailey , Peter J. Cameron

To avoid multicollinearity in regression analysis, Ye and Zhou(2013) proposed $K-$optimality criterion. By far the most popular models for modeling the response of a mixture experiment are the Scheff\'{e} models. However, there have been no…

Statistics Theory · Mathematics 2022-10-17 Hao-sheng Jiang , Jia-li Chen , Chong-qi Zhang

In this paper some new properties and computational tools for finding KL-optimum designs are provided. KL-optimality is a general criterion useful to select the best experimental conditions to discriminate between statistical models. A…

Methodology · Statistics 2018-01-04 Giacomo Aletti , Caterina May , Chiara Tommasi

Causal inference on a population of units connected through a network often presents technical challenges, including how to account for interference. In the presence of local interference, for instance, potential outcomes of a unit depend…

Methodology · Statistics 2018-04-02 Laura Forastiere , Edoardo M. Airoldi , Fabrizia Mealli

Space-filling designs are commonly used in computer experiments to fill the space of inputs so that the input-output relationship can be accurately estimated. However, in certain applications such as inverse design or feature-based…

Methodology · Statistics 2023-09-08 Shangkun Wang , Adam P. Generale , Surya R. Kalidindi , V. Roshan Joseph

To minimize the mean squared error (MSE) in global average treatment effect (GATE) estimation under network interference, a popular approach is to use a cluster-randomized design. However, in the presence of homophily, which is common in…

In this paper we present a new method for determining optimal designs for enzyme inhibition kinetic models, which are used to model the influence of the concentration of a substrate and an inhibition on the velocity of a reaction. The…

Methodology · Statistics 2017-09-18 Kirsten Schorning , Holger Dette , Katrin Kettelhake , Tilman Möller

In this paper, we present a novel tolerance allocation algorithm for the assessment and control of geometric variation on system performance that is applicable to any system of partial differential equations. In particular, we parameterize…

Numerical Analysis · Mathematics 2019-04-16 Joseph Benzaken , Alireza Doostan , John A. Evans

In this paper we extend the results of Radloff and Schwabe (2018), which could be applied for example to Poisson regression, negative binomial regression and proportional hazard models with censoring, to a wider class of non-linear multiple…

Methodology · Statistics 2021-04-07 Martin Radloff , Rainer Schwabe