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Currently self-report pain ratings are the gold standard in clinical pain assessment. However, the development of objective automatic measures of pain could substantially aid pain diagnosis and therapy. Recent neuroimaging studies have…

Image and Video Processing · Electrical Eng. & Systems 2019-07-31 Daniel Lopez-Martinez , Ke Peng , Arielle Lee , David Borsook , Rosalind Picard

Background: The role of neonatal pain on the developing nervous system is not completely understood, but evidence suggests that sensory pathways are influenced by an infants pain experience. Research has shown that an infants previous pain…

Assessing pain in patients unable to speak (also called non-verbal patients) is extremely complicated and often is done by clinical judgement. However, this method is not reliable since patients vital signs can fluctuate significantly due…

Machine Learning · Computer Science 2020-12-29 Raul Fernandez Rojas , Julio Romero , Jehu Lopez-Aparicio , Keng-Liang Ou

Currently there is no validated objective measure of pain. Recent neuroimaging studies have explored the feasibility of using functional near-infrared spectroscopy (fNIRS) to measure alterations in brain function in evoked and ongoing pain.…

Machine Learning · Computer Science 2018-08-22 Daniel Lopez-Martinez , Ke Peng , Sarah C. Steele , Arielle J. Lee , David Borsook , Rosalind Picard

To understand Working of Human Brain measurements related to the brain function are required. These measurements should be possibly non-invasive. Brain should be disturbed as less as possible during the measurement. Integration of various…

Emerging Technologies · Computer Science 2015-06-16 Revati Shriram , M. Sundhararajan , Nivedita Daimiwal

Functional Near-Infrared Spectroscopy (fNIRS) is a non-invasive, real-time method for monitoring brain activity by measuring hemodynamic responses in the cerebral cortex. However, existing systems are expensive, bulky, and limited to…

Signal Processing · Electrical Eng. & Systems 2025-05-28 Tony Kim , Haotian Liu , Chiung-Ting Huang , Ingrid Wu , Xilin Liu

Functional Near-Infrared Spectroscopy (fNIRS) is a non-invasive form of Brain-Computer Interface (BCI). It is used for the imaging of brain hemodynamics and has gained popularity due to the certain pros it poses over other similar…

Machine Learning · Computer Science 2021-01-19 Talha Siddique , Md Shaad Mahmud

People with Multiple Sclerosis (MS) complain of problems with hand dexterity and cognitive fatigue. However, in many cases, impairments are subtle and difficult to detect. Functional near-infrared spectroscopy (fNIRS) is a non-invasive…

Machine Learning · Computer Science 2025-09-29 Sadman Saumik Islam , Bruna Dalcin Baldasso , Davide Cattaneo , Xianta Jiang , Michelle Ploughman

The objective of this study was to characterize hemodynamic changes during trans-vascular stimulation of the renal nerve and their dependence on stimulation parameters. We employed a stimulation catheter inserted in the right renal artery…

Quantitative Methods · Quantitative Biology 2024-06-06 Filippo Agnesi , Lucia Carlucci , Gia Burjanadze , Fabio Bernini , Khatia Gabisonia , John W Osborn , Silvestro Micera , Fabio A. Recchia

Significance: This work targets the contamination of optical signals by superficial hemodynamics, which is one of the chief hurdles in non-invasive optical measurements of the human brain. Aim: To identify optimal source-detector distances…

Medical Physics · Physics 2023-01-05 Giles Blaney , Cristianne Fernandez , Angelo Sassaroli , Sergio Fantini

Neuroimaging data allows researchers to model the relationship between multivariate patterns of brain activity and outcomes related to mental states and behaviors. However, the existence of outlying participants can potentially undermine…

Methodology · Statistics 2026-03-17 Dongliang Zhang , Masoud Asgharian , Martin A. Lindquist

In the current paper, we introduce a parametric data-driven model for functional near-infrared spectroscopy that decomposes a signal into a series of independent, rescaled, time-shifted, hemodynamic basis functions. Each decomposed waveform…

Signal Processing · Electrical Eng. & Systems 2020-01-24 Marco A. Pinto-Orellana , Diego C. Nascimento , Peyman Mirtaheri , Rune Jonassen , Anis Yazidi , Hugo L. Hammer

In this paper we introduce a new hierarchical model for the simultaneous detection of brain activation and estimation of the shape of the hemodynamic response in multi-subject fMRI studies. The proposed approach circumvents a major…

Applications · Statistics 2015-11-13 David Degras , Martin A. Lindquist

Physics-Informed Neural Networks (PINNs) show significant potential for solving inverse problems, especially when observations are limited and sparse, provided that the relevant physical equations are known. We use PINNs to estimate smooth…

Numerical Analysis · Mathematics 2025-08-06 Moises Sierpe , Ernesto Castillo , Hernan Mella , Felipe Galarce

Neural stimulation represents a powerful technique for neural disorder treatment. This paper deals with optimization of coil design parameters to be used during stimulation for modulation of neuronal firing to achieve pain relief. Pain…

Neurons and Cognition · Quantitative Biology 2016-09-14 Raunaq Pradhan , Yuanjin Zheng

The fundamentals of near infrared spectroscopy (NIRS) are reviewed. This technique allows to measure the oxygenation of the brain tissue. The particular problems involved in detecting regional brain oxygenation (rSO2) are discussed. The…

Biological Physics · Physics 2011-03-30 Alexander Gersten , Jacqueline Perle , Amir Raz , Robert Fried

It is now recognized that important information can be extracted from the brain spontaneous activity, as exposed by recent analysis using a repertoire of computational methods. In this context a novel method, based on a blind deconvolution…

Neurons and Cognition · Quantitative Biology 2013-11-01 Guorong Wu , Enzo Tagliazucchi , Dante R. Chialvo , Daniele Marinazzo

Physics-informed neural networks (PINNs) have emerged as a powerful tool for solving inverse problems, especially in cases where no complete information about the system is known and scatter measurements are available. This is especially…

Computational Engineering, Finance, and Science · Computer Science 2023-08-03 Jeremias Garay , Jocelyn Dunstan , Sergio Uribe , Francisco Sahli Costabal

While computer vision models have made incredible strides in static image recognition, they still do not match human performance in tasks that require the understanding of complex, dynamic motion. This is notably true for real-world…

Neurons and Cognition · Quantitative Biology 2025-04-09 Jacob Yeung , Andrew F. Luo , Gabriel Sarch , Margaret M. Henderson , Deva Ramanan , Michael J. Tarr

Pain is a multifaceted phenomenon that affects a substantial portion of the population. Reliable and consistent evaluation supports individuals experiencing pain and enables the development of effective and advanced management strategies.…

Artificial Intelligence · Computer Science 2025-09-17 Stefanos Gkikas , Ioannis Kyprakis , Manolis Tsiknakis
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