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Eukaryotic cells are able to sense chemical gradients in a wide range of environments. We show that, if a cell is exposed to a highly variable environment, it may gain chemotactic accuracy by expressing multiple receptor types with varying…

Cell Behavior · Quantitative Biology 2020-11-04 Austin Hopkins , Brian A. Camley

Using a realistic model of activity dependent dynamical synapses and a standard integrate and fire neuron model we study, both analytically and numerically, the conditions in which a postsynaptic neuron efficiently detects temporal…

Neurons and Cognition · Quantitative Biology 2007-05-23 Jorge F. Mejias , Joaquin J. Torres

Cells adapt to changing environments by sensing ligand concentrations using specific receptors. The accuracy of sensing is ultimately limited by the finite number of ligand molecules bound by receptors. Previously derived physical limits to…

Subcellular Processes · Quantitative Biology 2019-11-13 Thierry Mora , Ilya Nemenman

Cooperativity arising from local interactions in equilibrium receptor systems provides gain, but does not increase sensory performance, as measured by the signal-to-noise ratio (SNR) due to a fundamental tradeoff between gain and intrinsic…

Molecular Networks · Quantitative Biology 2013-07-12 Monica Skoge , Sahin Naqvi , Yigal Meir , Ned S. Wingreen

Multiplicity correlation measurements provide insight into the dynamics of high energy collisions. Models describing these collisions need these correlation measurements to tune the strengths of the underlying QCD processes which influence…

Nuclear Experiment · Physics 2016-04-27 K. Gulbrandsen , C. Soegaard

Population-wide screening is a powerful tool for controlling infectious diseases. Group testing enables such screening despite limited resources. Viral concentration of pooled samples are often positively correlated, either because…

Applications · Statistics 2025-04-01 Jiayue Wan , Yujia Zhang , Peter I. Frazier

We study environments in which agents are randomly matched to play a Prisoner's Dilemma, and each player observes a few of the partner's past actions against previous opponents. We depart from the existing related literature by allowing a…

Theoretical Economics · Economics 2020-06-30 Yuval Heller , Erik Mohlin

To adapt their behaviour in changing environments, cells sense concentrations by binding external ligands to their receptors. However, incorrect ligands may bind nonspecifically to receptors, and when their concentration is large, this…

Molecular Networks · Quantitative Biology 2015-07-23 Thierry Mora

The reliable detection of environmental molecules in the presence of noise is an important cellular function, yet the underlying computational mechanisms are not well understood. We introduce a model of two interacting sensors which allows…

Biological Physics · Physics 2020-02-25 Vudtiwat Ngampruetikorn , David J. Schwab , Greg J. Stephens

Recently, there has been a significant interest in developing cooperative sensing systems for certain types of wireless applications. In such systems, a group of sensing nodes periodically collect measurements about the signals being…

Information Theory · Computer Science 2015-06-11 Harish Ganapathy , Constantine Caramanis , Lei Ying

Eukaryotic cells generally sense chemical gradients using the binding of chemical ligands to membrane receptors. In order to perform chemotaxis effectively in different environments, cells need to adapt to different concentrations. We…

Cell Behavior · Quantitative Biology 2026-04-20 Vishnu Srinivasan , Wei Wang , Brian A. Camley

This paper considers the real-time power quality monitoring in power grid systems. The goal is to detect the occurrence of disturbances in the nominal sinusoidal voltage/current signal as quickly as possible such that protection measures…

Systems and Control · Computer Science 2016-01-26 Shang Li , Xiaodong Wang

Biological cells are often found to sense their chemical environment near the single-molecule detection limit. Surprisingly, this precision is higher than simple estimates of the fundamental physical limit, hinting towards active sensing…

Biological Physics · Physics 2015-11-06 Gerardo Aquino , Luke Tweedy , Doris Heinrich , Robert G. Endres

Non-stationarity affects the sensitivity of change detection in correlated systems described by sets of measurable variables. We study this by projecting onto different principal components. Non-stationarity is modeled as multiple normal…

Data Analysis, Statistics and Probability · Physics 2023-06-22 Henrik M. Bette , Michael Schreckenberg , Thomas Guhr

Positive correlations in the activity of neurons are widely observed in the brain. Previous studies have shown these correlations to be detrimental to the fidelity of population codes or at best marginally favorable compared to independent…

Neurons and Cognition · Quantitative Biology 2013-07-22 Rava Azeredo da Silveira , Michael J. Berry

In this paper, we mathematically characterize the improvement in device localizability achieved by allowing collaboration among devices. Depending on the detection sensitivity of the receivers in the devices, it is not unusual for a device…

Information Theory · Computer Science 2015-07-22 Javier Schloemann , Harpreet S. Dhillon , R. Michael Buehrer

Olfactory receptor usage is highly heterogeneous, with some receptor types being orders of magnitude more abundant than others. We propose an explanation for this striking fact: the receptor distribution is tuned to maximally represent…

Neurons and Cognition · Quantitative Biology 2019-01-23 Tiberiu Tesileanu , Simona Cocco , Remi Monasson , Vijay Balasubramanian

Most existing works on physical-layer (PHY) cooperation (beyond routing) focus on how to best use a given, static relay network--while wireless networks are anything but static. In this paper, we pose a different set of questions: given…

Networking and Internet Architecture · Computer Science 2016-12-08 Ayan Sengupta , Yahya H. Ezzeldin , Siddhartha Brahma , Christina Fragouli , Suhas Diggavi

This paper addresses the problem of quickest detection of a change in the maximal coherence between columns of a $n\times p$ random matrix based on a sequence of matrix observations having a single unknown change point. The random matrix is…

Statistics Theory · Mathematics 2018-05-01 Taposh Banerjee , Hamed Firouzi , Alfred O. Hero

In biological cells and novel diagnostic devices biochemical receptors need to be sensitive to extremely small concentration changes of signaling molecules. The accuracy of such molecular signaling is ultimately limited by the counting…

Subcellular Processes · Quantitative Biology 2023-04-06 Aljaz Godec , Ralf Metzler