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All signals obtained as instrumental response of analytical apparatus are affected by noise, as in Raman spectroscopy. Whereas Raman scattering is an inherently weak process, the noise background can lead to misinterpretations. Although…

Raman spectroscopy can provide insight into the molecular composition of cells and tissue. Consequently, it can be used as a powerful diagnostic tool, e.g. to help identify changes in molecular contents with the onset of disease. But robust…

Medical Physics · Physics 2023-08-02 Ciaran Bench , Mads S. Bergholt , Mohamed Ali al-Badri

Raman spectroscopy reveals chemically specific information and provides label-free insight into the molecular world. However, the signals are intrinsically weak and call for enhancement techniques. Here, we demonstrate Purcell enhancement…

Coherent Diffractive Imaging is a lensless technique that allows imaging of matter at a spatial resolution not limited by lens aberrations. This technique exploits the measured diffraction pattern of a coherent beam scattered by periodic…

Computational Physics · Physics 2025-08-27 Alessandro Colombo , Davide Emilio Galli , Liberato De Caro , Francesco Scattarella , Elvio Carlino

We propose a novel approach using Multiplex-Coherent Anti-Stokes Raman Scattering (M-CARS) for la-bel-free discriminations in biomedical tissues. The strategy is based on the evaluation of the contrast be-tween resonant and nonresonant…

Raman scattering spectroscopy is widely used as an analytical technique in various fields, but its measurement process tends to be slow due to the low scattering cross-section. In the last decade, various broadband coherent Raman scattering…

Optics · Physics 2025-05-06 Takuma Nakamura , Kazuki Hashimoto , Takuro Ideguchi

Surface-enhanced Raman scattering (SERS) combines analyte-specificity and single-molecule sensitivity, but its potential is limited by slow readout where sophisticated nanosensors are analysed in a serial fashion, one particle at a time. We…

Noise manifests ubiquitously in nonlinear spectroscopy, where multiple sources contribute to experimental signals generating interrelated unwanted components, from random point-wise fluctuations to structured baseline signals. Mitigating…

We demonstrate coherent anti-Stokes Raman scattering (CARS) microscopy in a wide-field setup with nanosecond laser pulse excitation. In contrast to confocal setups, the image of a sample can be recorded with a single pair of excitation…

Optics · Physics 2009-11-11 Christoph Heinrich , Stefan Bernet , Monika Ritsch-Marte

In coherent X-ray diffraction microscopy the diffraction pattern generated by a sample illuminated with coherent x-rays is recorded, and a computer algorithm recovers the unmeasured phases to synthesize an image. By avoiding the use of a…

Purpose: subject motion and static field (B$_0$) drift are known to reduce the quality of single voxel MR spectroscopy data due to incoherent averaging. Retrospective correction has previously been shown to improve data quality by adjusting…

Quantitative Methods · Quantitative Biology 2018-09-17 Martin Wilson

Miniaturized photonic cavities generating nonlinear optical states of light are central to telecommunications and metrology applications. The emergence of such states is primarily underpinned by the ubiquitous Kerr nonlinearity that is…

Correlated rotational alignment spectroscopy correlates observables of ultrafast gas-phase spectroscopy with high-resolution, broad-band rotational Raman spectra. This article reviews the measurement principle of CRASY, existing…

Chemical Physics · Physics 2024-03-07 Thomas Schultz

Stimulated Raman scattering (SRS) is a powerful method for label-free imaging and spectroscopy of materials. Recent experiments have shown that quantum-enhanced Raman scattering can surpass the shot noise limit and improve the sensitivity…

Quantum Physics · Physics 2025-02-27 Frank Schlawin , Manuel Gessner

Three-color coherent anti-Stokes Raman scattering represents non-degenerate four wave mixing process that includes both a non-resonant and resonant processes, the contributions of which depend on how the molecular vibrational modes are…

Optics · Physics 2020-10-14 Supriya Nagpal , Bryan Semon , Gombojav O. Ariunbold

Raman spectroscopy stands as a cornerstone technique for probing collective excitations and emergent quantum phases in solids. While polarization-resolved Raman scattering has been widely used to extract symmetry information of eigenmodes,…

Materials Science · Physics 2026-02-24 Di Cheng , Junxiang Li , Shizhuo Luo , Zehao Chen , Xinwei Li

The M\"ossbauer spectroscopy is presented as an alternative experimental technique to be pursued in the detec-tion of Coherent Elastic{\nu}-Nucleus Scattering (CENNS). The neutrino transferred energy in the neutrino-nucleusinteraction…

High Energy Physics - Phenomenology · Physics 2020-10-23 C Marques , G S Dias , H S Chavez , S B Duarte

The emergence of label-free microscopy techniques has significantly improved our ability to precisely characterize biochemical targets, enabling non-invasive visualization of cellular organelles and tissue organization. Each label-free…

Optics · Physics 2024-05-08 Lang Wang , Maxine Xii , Ali Pezeshki , Randy Bartels

Raman lasers based on integrated silica whispering gallery mode resonant cavities have enabled numerous applications from telecommunications to biodetection. To overcome the intrinsically low Raman gain value of silica, these devices…

Optics · Physics 2020-01-06 Hyungwoo Choi , Dongyu Chen , Fan Du , Rene Zeto , Andrea M Armani

Surface-enhanced Raman spectroscopy (SERS) is a potential fast and inexpensive method of analyte quantification, which can be combined with deep learning to discover biomarker-disease relationships. This study aims to address present…

Quantitative Methods · Quantitative Biology 2024-11-14 Jihan K. Zaki , Jakub Tomasik , Jade A. McCune , Sabine Bahn , Pietro Liò , Oren A. Scherman