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We investigate the migration of particles of different geometrical shapes and sizes in a scaled-up model of a gravity-driven deterministic lateral displacement (g-DLD) device. Specifically, particles move through a square array of…

Fluid Dynamics · Physics 2016-05-04 Mingliang Jiang , Kostyantyn Budzan , German Drazer

We use a macromodel of a flow-driven deterministic lateral displacement (DLD) microfluidic system to investigate conditions leading to size-separation of suspended particles. This model system can be easily reconfigured to establish an…

Fluid Dynamics · Physics 2016-04-27 Siqi Du , German Drazer

We present a simple solution to enhance the separation ability of deterministic lateral displacement (DLD) systems by expanding the two-dimensional nature of these devices and driving the particles into size-dependent, fully…

Soft Condensed Matter · Physics 2016-04-27 Siqi Du , German Drazer

An electrokinetically-driven deterministic lateral displacement (e-DLD) device is proposed for the continuous, two-dimensional fractionation of suspensions in microfluidic platforms. The suspended species are driven through an array of…

Fluid Dynamics · Physics 2016-05-04 Srinivas Hanasoge , Raghavendra Devendra , Javier F. Diez , German Drazer

Deterministic lateral displacement (DLD) devices separate micrometer-scale particles in solution based on their size using a laminar microfluidic flow in an array of obstacles. We investigate array geometries with rational row-shift…

We investigate the motion of suspended particles past a single line of equally spaced cylindrical posts that is slanted with respect to the driving force. We show that such a one-dimensional array of posts can fractionate particles…

Fluid Dynamics · Physics 2016-05-04 Raghavendra Devendra , German Drazer

The ability to separate and analyze chemical species with high resolution, sensitivity, and throughput is central to the development of microfluidics systems. Deterministic lateral displacement (DLD) is a continuous separation method based…

Fluid Dynamics · Physics 2014-04-15 Timothy J. Bowman , German Drazer , Joelle Frechette

We analyze the trajectory of suspended spherical particles moving through a square array of obstacles, in the deterministic limit and at zero Reynolds number. We show that, in the dilute approximation of widely separated obstacles, the…

Fluid Dynamics · Physics 2016-05-04 Sumedh R. Risbud , German Drazer

We present a model including diffusion and particle-size dispersion for separation of particles in deterministic lateral displacement devices also known as bumper arrays. We determine the upper critical diameter for diffusion-dominated…

Fluid Dynamics · Physics 2009-01-20 Martin Heller , Henrik Bruus

We investigate the transport and separation of overdamped particles under the action of a uniform external force in a two-dimensional periodic energy landscape. Exact results are obtained for the deterministic transport in a square lattice…

Soft Condensed Matter · Physics 2013-05-29 John Herrmann , Michael Karweit , German Drazer

An important step in diagnostics is the isolation of specific cells and microorganisms of interest from blood. Since such bioparticles are often present at very low concentrations, throughput needs to be as high as possible. In addition, to…

Soft Condensed Matter · Physics 2019-07-31 Stefan H. Holm , Zunmin Zhang , Jason P. Beech , Gerhard Gompper , Dmitry A. Fedosov , Jonas O. Tegenfeldt

We investigate the effect of particle volume fraction on the efficiency of deterministic lateral displacement (DLD) devices. DLD is a popular passive sorting technique for microfluidic applications. Yet, it has been designed for treating…

Soft Condensed Matter · Physics 2015-10-27 Rohan Vernekar , Timm Krüger

In conventional Deterministic Lateral Displacement (DLD), the migration behavior of a particle of specific size is determined by the critical diameter (Dc), which is predefined by the device's geometry. In contrast to the typical approach…

Fluid Dynamics · Physics 2024-01-17 Ali Kheirkhah Barzoki , Amir Shamloo

Within microcentrifuge devices, a microfluidic vortex separates larger particles from a heterogeneous suspension using inertial migration, a phenomenon that causes particles to migrate across streamlines. The ability to selectively capture…

Fluid Dynamics · Physics 2023-03-14 Samuel Christensen , Marcus Roper

In this paper, we describe the unification and extension of multiple kinematic theories on the advection of colloidal particles through periodic obstacle lattices of arbitrary geometry and infinitesimally small obstacle size. We focus…

Computational Physics · Physics 2020-03-25 Arnaldo Rodriguez-Gonzalez , Jason P. Gleghorn , Brian J. Kirby

Deterministic lateral displacement (DLD) is a popular technique for size-based separation of particles. One of the challenges in design of DLD chips is to eliminate the disturbance of fluid flow patterns caused by channel sidewalls…

Fluid Dynamics · Physics 2025-03-25 Aryan Mehboudi , Shrawan Singhal , S. V. Sreenivasan

We study deformability-based sorting of same-size RBCs via DLD using an in-house integral equation solver. Our goal is to quantitatively characterize the physical mechanisms that enable the cell separation. To this end, we systematically…

Computational Physics · Physics 2018-11-30 Gokberk Kabacaoglu , George Biros

We present an experimental study of segregation of granular matter in a quasi-two dimensional silo emptying out of an orifice. Size separation is observed when multi-sized particles are used with the larger particles found in the center of…

Statistical Mechanics · Physics 2009-10-31 Azadeh Samadani , A. Pradhan , A. Kudrolli

Spontaneous segregation of run-and-tumble particles with different velocities in microchannels is investigated by numerical simulations. Self-propelled particles are known to accumulate in the proximity of walls. Here we show how fast…

Soft Condensed Matter · Physics 2014-09-05 Andrea Costanzo , Jens Elgeti , Thorsten Auth , Gerhard Gompper , Marisol Ripoll

Deterministic lateral displacement (DLD) is a high-resolution separation technique used in various fields. A fundamental challenge in DLD is ensuring uniform flow characteristics across channel, particularly near sidewalls where pillar…

Fluid Dynamics · Physics 2025-06-10 Aryan Mehboudi , Shrawan Singhal , S. V. Sreenivasan
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