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Deep learning has led to significant advances in artificial intelligence, in part, by adopting strategies motivated by neurophysiology. However, it is unclear whether deep learning could occur in the real brain. Here, we show that a deep…

Neurons and Cognition · Quantitative Biology 2017-04-11 Jordan Guergiuev , Timothy P. Lillicrap , Blake A. Richards

In the cerebral cortex, neurons are subject to a continuous bombardment of synaptic inputs originating from the network's background activity. This leads to ongoing, mostly subthreshold membrane dynamics that depends on the statistics of…

Biological Physics · Physics 2009-11-07 Ulrich Hillenbrand

Recurrent neural networks have gained widespread use in modeling sequential data. Learning long-term dependencies using these models remains difficult though, due to exploding or vanishing gradients. In this paper, we draw connections…

Machine Learning · Statistics 2019-02-27 Bo Chang , Minmin Chen , Eldad Haber , Ed H. Chi

Traditional mathematical approaches to studying analytically the dynamics of neural networks rely on the mean-field approximation, which is rigorously applicable only to networks of infinite size. However, all existing real biological…

Neurons and Cognition · Quantitative Biology 2019-04-30 Diego Fasoli , Stefano Panzeri

In this work we propose an artificial neural network functional to the ground-state energy of fermionic interacting particles in homogeneous chains described by the Hubbard model. Our neural network functional was proven to has an excellent…

Computational Physics · Physics 2019-02-18 C. A. Custodio , E. R. Filletti , V. V. França

We study in this paper the effect of an unique initial stimulation on random recurrent networks of leaky integrate and fire neurons. Indeed given a stochastic connectivity this so-called spontaneous mode exhibits various non trivial…

Neural and Evolutionary Computing · Computer Science 2007-05-23 H. Soula , G. Beslon , O. Mazet

In developing brain, axons and dendrites are capable of connecting to each other with high precision. Recent advances in imaging have allowed for the monitoring of axonal, dendritic, and synapse dynamics in vivo. It is observed that the…

Neurons and Cognition · Quantitative Biology 2008-04-08 Dmitry Tsigankov , Alexei Koulakov

A growing body of research indicates that structural plasticity mechanisms are crucial for learning and memory consolidation. Starting from a simple phenomenological model, we exploit a mean-field approach to develop a theoretical framework…

Neurons and Cognition · Quantitative Biology 2024-06-19 Gianmarco Tiddia , Luca Sergi , Bruno Golosio

Deep Neural Networks (DNNs) excel at many tasks, often rivaling or surpassing human performance. Yet their internal processes remain elusive, frequently described as "black boxes." While performance can be refined experimentally, achieving…

Disordered Systems and Neural Networks · Physics 2025-02-03 Sebastiano Ariosto

Spiking neural networks (SNNs) are distributed trainable systems whose computing elements, or neurons, are characterized by internal analog dynamics and by digital and sparse synaptic communications. The sparsity of the synaptic spiking…

Machine Learning · Computer Science 2020-01-08 Hyeryung Jang , Osvaldo Simeone , Brian Gardner , André Grüning

The statistics of correlations are central quantities characterizing the collective dynamics of recurrent neural networks. We derive exact expressions for the statistics of correlations of nonlinear recurrent networks in the limit of a…

Neurons and Cognition · Quantitative Biology 2026-04-23 German Mato , Facundo Rigatuso , Gonzalo Torroba

Studies of the dynamics of nonlinear recurrent neural networks often assume independent and identically distributed couplings, but large-scale connectomics data indicate that biological neural circuits exhibit markedly different…

Neurons and Cognition · Quantitative Biology 2025-10-28 David G. Clark , Owen Marschall , Alexander van Meegen , Ashok Litwin-Kumar

A central challenge in the computational modeling of neural dynamics is the trade-off between accuracy and simplicity. At the level of individual neurons, nonlinear dynamics are both experimentally established and essential for neuronal…

Brains learn to represent information from a large set of stimuli, typically by weak supervision. Unsupervised learning is therefore a natural approach for exploring the design of biological neural networks and their computations.…

Neurons and Cognition · Quantitative Biology 2025-10-17 Roy Urbach , Elad Schneidman

A new field of research is rapidly expanding at the crossroad between statistical physics, information theory and combinatorial optimization. In particular, the use of cutting edge statistical physics concepts and methods allow one to solve…

Neurons and Cognition · Quantitative Biology 2008-03-28 Marc Mezard , Thierry Mora

Neural-network processing in machine learning applications relies on layer synchronization. This is practiced even in artificial Spiking Neural Networks (SNNs), which are touted as consistent with neurobiology, in spite of processing in the…

Neural and Evolutionary Computing · Computer Science 2025-10-27 Roel Koopman , Amirreza Yousefzadeh , Mahyar Shahsavari , Guangzhi Tang , Manolis Sifalakis

Learning is a complex dynamical process shaped by a range of interconnected decisions. Careful design of hyperparameter schedules for artificial neural networks or efficient allocation of cognitive resources by biological learners can…

Disordered Systems and Neural Networks · Physics 2025-07-11 Francesca Mignacco , Francesco Mori

Deep learning has seen remarkable developments over the last years, many of them inspired by neuroscience. However, the main learning mechanism behind these advances - error backpropagation - appears to be at odds with neurobiology. Here,…

Neurons and Cognition · Quantitative Biology 2018-10-29 João Sacramento , Rui Ponte Costa , Yoshua Bengio , Walter Senn

Biological neurons can detect complex spatio-temporal features in spiking patterns via their synapses spread across across their dendritic branches. This is achieved by modulating the efficacy of the individual synapses, and by exploiting…

Emerging Technologies · Computer Science 2023-12-15 Melika Payvand , Simone D'Agostino , Filippo Moro , Yigit Demirag , Giacomo Indiveri , Elisa Vianello

Spiking Neural Networks (SNNs) are distributed trainable systems whose computing elements, or neurons, are characterized by internal analog dynamics and by digital and sparse synaptic communications. The sparsity of the synaptic spiking…

Signal Processing · Electrical Eng. & Systems 2019-10-22 Hyeryung Jang , Osvaldo Simeone , Brian Gardner , André Grüning