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In this work we deal with parameter estimation in a latent variable model, namely the multiple-hidden i.i.d. model, which is derived from multiple alignment algorithms. We first provide a rigorous formalism for the homology structure of k…

Applications · Statistics 2012-02-03 Ana Arribas-Gil

Motivation: Radiomics refers to the high-throughput mining of quantitative features from radiographic images. It is a promising field in that it may provide a non-invasive solution for screening and classification. Standard machine learning…

Complex phenomena in engineering and the sciences are often modeled with computationally intensive feed-forward simulations for which a tractable analytic likelihood does not exist. In these cases, it is sometimes necessary to estimate an…

Methodology · Statistics 2020-06-18 Niccolò Dalmasso , Ann B. Lee , Rafael Izbicki , Taylor Pospisil , Ilmun Kim , Chieh-An Lin

We review Quasi Maximum Likelihood estimation of factor models for high-dimensional panels of time series. We consider two cases: (1) estimation when no dynamic model for the factors is specified (Bai and Li, 2012, 2016); (2) estimation…

Econometrics · Economics 2024-10-08 Matteo Barigozzi

We propose a closed-form spectral framework for relative log-density estimation in linearly parameterized probabilistic models, including unnormalized and conditional models. This is achieved by representing the Kullback-Leibler (KL)…

Machine Learning · Computer Science 2026-05-12 Francis Bach

We present a modular, extensible likelihood framework for spectroscopic inference based on synthetic model spectra. The subtraction of an imperfect model from a continuously sampled spectrum introduces covariance between adjacent datapoints…

Solar and Stellar Astrophysics · Physics 2015-10-21 Ian Czekala , Sean M. Andrews , Kaisey S. Mandel , David W. Hogg , Gregory M. Green

Recent years have seen a rapid expansion of the model space explored in statistical phylogenetics, emphasizing the need for new approaches to statistical model representation and software development. Clear communication and representation…

Populations and Evolution · Quantitative Biology 2013-12-10 Sebastian Höhna , Tracy A. Heath , Bastien Boussau , Michael J. Landis , Fredrik Ronquist , John P. Huelsenbeck

The reconstruction of phylogenetic trees from molecular sequence data relies on modelling site substitutions by a Markov process, or a mixture of such processes. In general, allowing mixed processes can result in different tree topologies…

Populations and Evolution · Quantitative Biology 2016-09-07 Marta Casanellas , Mike Steel

Applying a method to reconstruct a phylogenetic tree from random data provides a way to detect whether that method has an inherent bias towards certain tree `shapes'. For maximum parsimony, applied to a sequence of random 2-state data, each…

Populations and Evolution · Quantitative Biology 2014-06-03 Mareike Fischer , Michelle Galla , Lina Herbst , Mike Steel

As an alternative to parsimony analyses, stochastic models have been proposed (Lewis, 2001), (Nylander, et al., 2004) for morphological characters, so that maximum likelihood or Bayesian analyses may be used for phylogenetic inference. A…

Populations and Evolution · Quantitative Biology 2009-12-20 Elizabeth S. Allman , Mark T. Holder , John A. Rhodes

We show that each member of a broad class of Markovian population models induces a unique stochastic process on the space of genealogies. We construct this genealogy process and derive exact expressions for the likelihood of an observed…

Quantitative Methods · Quantitative Biology 2026-05-22 Aaron A. King , Qianying Lin , Edward L. Ionides

Phylogenetics uses alignments of molecular sequence data to learn about evolutionary trees relating species. Along branches, sequence evolution is modelled using a continuous-time Markov process characterised by an instantaneous rate…

Phylogenetic trees are simple models of evolutionary processes. They describe conditionally independent divergent evolution of taxa from common ancestors. Phylogenetic trees commonly do not have enough flexibility to adequately model all…

Populations and Evolution · Quantitative Biology 2025-11-11 Jonathan D. Mitchell , Barbara R. Holland

To estimate cosmological parameters from a given dataset, we need to construct a likelihood function, which sometimes has a complicated functional form. We introduce the copula, a mathematical tool to construct an arbitrary multivariate…

Cosmology and Nongalactic Astrophysics · Physics 2011-02-25 Masanori Sato , Kiyotomo Ichiki , Tsutomu T. Takeuchi

Empirical likelihood is an attractive inferential framework that respects natural parameter boundaries, but existing approaches typically require smoothness of the functional and miscalibrate substantially when these assumptions are…

Methodology · Statistics 2026-03-31 Hongseok Namkoong

Likelihood-based methods are widely considered the best approaches for reconstructing ancestral states. Although much effort has been made to study properties of these methods, previous works often assume that both the tree topology and…

Methodology · Statistics 2021-04-02 Lam Si Tung Ho , Edward Susko

We present a framework to define a large class of neural networks for which, by construction, training by gradient flow provably reaches arbitrarily low loss when the number of parameters grows. Distinct from the fixed-space global…

Optimization and Control · Mathematics 2025-01-13 David A. R. Robin , Kevin Scaman , Marc Lelarge

Conditional copula models allow dependence structures to vary with observed covariates while preserving a separation between marginal behavior and association. We study the uniform asymptotic behavior of kernel-weighted local likelihood…

Statistics Theory · Mathematics 2026-01-06 Mathias Nthiani Muia

This work introduces Bilinear Classes, a new structural framework, which permit generalization in reinforcement learning in a wide variety of settings through the use of function approximation. The framework incorporates nearly all existing…

Machine Learning · Computer Science 2021-07-13 Simon S. Du , Sham M. Kakade , Jason D. Lee , Shachar Lovett , Gaurav Mahajan , Wen Sun , Ruosong Wang

Random features is a powerful universal function approximator that inherits the theoretical rigor of kernel methods and can scale up to modern learning tasks. This paper views uncertain system models as unknown or uncertain smooth functions…

Machine Learning · Computer Science 2021-06-25 Diego Agudelo-España , Yassine Nemmour , Bernhard Schölkopf , Jia-Jie Zhu