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A new algorithm, "HiER-leap", is derived which improves on the computational properties of the ER-leap algorithm for exact accelerated simulation of stochastic chemical kinetics. Unlike ER-leap, HiER-leap utilizes a hierarchical or…

Molecular Networks · Quantitative Biology 2012-12-18 David Orendorff , Eric Mjolsness

Process discovery is a family of techniques that helps to comprehend processes from their data footprints. Yet, as processes change over time so should their corresponding models, and failure to do so will lead to models that under- or…

Artificial Intelligence · Computer Science 2022-08-11 Andrea Burattin , Hugo A. López , Lasse Starklit

Classification models are a fundamental component of physical-asset management technologies such as structural health monitoring (SHM) systems and digital twins. Previous work introduced risk-based active learning, an online approach for…

Machine Learning · Computer Science 2022-07-13 Aidan J. Hughes , Lawrence A. Bull , Paul Gardner , Nikolaos Dervilis , Keith Worden

Drug discovery is a multi-stage process that comprises two costly major steps: pre-clinical research and clinical trials. Among its stages, lead optimization easily consumes more than half of the pre-clinical budget. We propose a combined…

Machine Learning · Computer Science 2020-11-30 Leili Zhang , Giacomo Domeniconi , Chih-Chieh Yang , Seung-gu Kang , Ruhong Zhou , Guojing Cong

Data-driven methods demonstrate considerable potential for accelerating the inherently expensive computational fluid dynamics (CFD) solvers. Nevertheless, pure machine-learning surrogate models face challenges in ensuring physical…

Fluid Dynamics · Physics 2024-09-12 Clément Caron , Philippe Lauret , Alain Bastide

In modeling time series data, we often need to augment the existing data records to increase the modeling accuracy. In this work, we describe a number of techniques to extract dynamic information about the current state of a large…

Machine Learning · Computer Science 2022-05-20 Jeeyung Kim , Mengtian Jin , Youkow Homma , Alex Sim , Wilko Kroeger , Kesheng Wu

We derive a new method to improve the statistics of identified particles at high transverse momentum (\pt) using online-triggered events by the Barrel Electro-Magnetic-Calorimeter (BEMC) detector. The BEMC is used to select hadronic…

High Energy Physics - Experiment · Physics 2011-12-20 Hongyu Da , Xiangli Cui , Gene Van Buren , J. C. Dunlop , Xin Dong , Lijuan Ruan , Anthony Timmins , Zebo Tang , Xiaolian Wang , Yichun Xu , Zhangbu Xu

Calculating free energies is an important and notoriously difficult task for molecular simulations. The rapid increase in computational power has made it possible to probe increasingly complex systems, yet extracting accurate free energies…

Chemical Physics · Physics 2014-07-29 Viveca Lindahl , Jack Lidmar , Berk Hess

Due to a hard dependency between time steps, large-scale simulations of gas using the Direct Simulation Monte Carlo (DSMC) method proceed at the pace of the slowest processor. Scalability is therefore achievable only by ensuring that the…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-02-19 William McDoniel , Paolo Bientinesi

The increasing demand for accelerated scientific discovery, driven by global challenges, highlights the need for advanced AI-driven robotics. Deploying robotic chemists in human-centric labs is key for the next horizon of autonomous…

Robotics · Computer Science 2026-03-12 Cenk Cetin , Shreyas Pouli , Gabriella Pizzuto

Sensitivity analysis of biochemical reactions aims at quantifying the dependence of the reaction dynamics on the reaction rates. The computation of the parameter sensitivities, however, poses many computational challenges when taking…

Molecular Networks · Quantitative Biology 2018-11-07 Vo Hong Thanh , Roberto Zunino , Corrado Priami

Developing an efficient method to accelerate the speed of molecular dynamics is a central theme in the field of molecular simulation. One category among the methods are collective-variable-based methods, which rely on predefined collective…

Chemical Physics · Physics 2024-08-27 Jiahao Fan , Yanze Wang , Dongdong Wang , Linfeng Zhang

Molecular dynamics simulations have become essential in many areas of atomistic modelling from drug discovery to materials science. They provide critical atomic-level insights into key dynamical events experiments cannot easily capture.…

Biological Physics · Physics 2024-06-14 Tiejun Wei , Balint Dudas , Edina Rosta

In this paper, we are interested in the acceleration of numerical simulations. We focus on a hypersonic planetary reentry problem whose simulation involves coupling fluid dynamics and chemical reactions. Simulating chemical reactions takes…

Machine Learning · Statistics 2022-10-03 Paul Novello , Gaël Poëtte , David Lugato , Simon Peluchon , Pietro Marco Congedo

Modelling the sudden depressurisation of superheated liquids through nozzles is a challenge because the pressure drop causes rapid flash boiling of the liquid. The resulting jet usually demonstrates a wide range of structures, including…

Fluid Dynamics · Physics 2021-12-15 David Schmidt , Romit Maulik , Konstantinos G. Lyras

Maintaining robust 3D perception under dynamic and unpredictable test-time conditions remains a critical challenge for autonomous driving systems. Existing test-time adaptation (TTA) methods often fail in high-variance tasks like 3D object…

Computer Vision and Pattern Recognition · Computer Science 2025-05-23 Huitong Yang , Zhuoxiao Chen , Fengyi Zhang , Zi Huang , Yadan Luo

Numerical simulations have played a vital role in the design of modern combustion systems. Over the last two decades, the focus of research has been on the development of the large eddy simulation (LES) approach, which leveraged the vast…

Computational Physics · Physics 2018-08-24 Venkat Raman , Malik Hassanaly

Regime switching is ubiquitous in many complex dynamical systems with multiscale features, chaotic behavior, and extreme events. In this paper, a causation entropy boosting (CEBoosting) strategy is developed to facilitate the detection of…

Dynamical Systems · Mathematics 2024-10-15 Chuanqi Chen , Nan Chen , Jin-Long Wu

Simulation plays a central role in scientific discovery. In many applications, the bottleneck is no longer running a simulator; it is choosing among large families of plausible simulators, each corresponding to different forward…

Accurate knowledge of the response of the detection system is very crucial for unambiguous interpretation of the experimental data. A simulation code has been developed using the Monte Carlo technique involving 3-body kinematics for the…

Instrumentation and Detectors · Physics 2019-01-14 S. K. Pandit , K. Mahata , A. Shrivastava , V. V. Parkar , K. Ramachandran
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