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One of the astounding consequences of quantum mechanics is that it allows the detection of a target using an incident probe, with only a low probability of interaction of the probe and the target. This 'quantum weirdness' could be applied…

We propose a simple design of a quantum electron microscope that ``queries'' a beam-sensitive phase object, such as a biological specimen, as part of quantum computation. Lower quantum query complexity, not the time complexity, of a quantum…

Quantum Physics · Physics 2026-04-15 Hiroshi Okamoto

We investigate the fundamental limit of biological quantum electron microscopy, which is designed to go beyond the shot noise limit. Inelastic scattering is expected to be the main obstacle in this setting, especially for thick specimens of…

Quantum Physics · Physics 2022-09-14 Hiroshi Okamoto

Feynman once asked physicists to build better electron microscopes to be able to watch biology at work. While electron microscopes can now provide atomic resolution, electron beam induced specimen damage precludes high resolution imaging of…

Instrumentation and Detectors · Physics 2016-12-16 Thomas Juffmann , Stewart A. Koppell , Brannon B. Klopfer , Colin Ophus , Robert Glaeser , Mark A. Kasevich

Technological advancement towards the quantum era requires secure communication, quantum computation, and ultra-sensitive sensing capabilities. Layered quantum materials (LQMs) have remarkable optoelectronic and quantum properties that can…

Mesoscale and Nanoscale Physics · Physics 2021-12-28 Ajit Kumar Dash , Mainak Mondal , Manvi Verma , Keerthana S Kumar , Akshay Singh

The challenge of imaging low-density objects in an electron microscope without causing beam damage is significant in modern TEM. This is especially true for life science imaging, where the sample, rather than the instrument, still…

Optics · Physics 2025-01-29 Francisco Vega Ibáñez , Jo Verbeeck

We show that quantum computational imaging is advantageous in the setting of low-dose electron microscopy of beam-sensitive specimens. Two qudits placed near the electron beam enable full transfer of quantum information between the electron…

Quantum Physics · Physics 2026-04-14 Hiroshi Okamoto

The major resolution-limiting factor in cryoelectron microscopy of unstained biological specimens is radiation damage by the very electrons that are used to probe the specimen structure. To address this problem, an electron microscopy…

Quantum Physics · Physics 2015-06-18 Hiroshi Okamoto

Electron and x-ray microscopes allow one to image the entire, unlabeled structure of hydrated materials at a resolution well beyond what visible light microscopes can achieve. However, both approaches involve ionizing radiation, so that…

Applied Physics · Physics 2020-04-22 Ming Du , Chris Jacobsen

A number of visions for a new generation of dose-efficient electron microscopes have been advanced. These proposals, while inspired by quantum principles, make little contact with the broader field of quantum metrology. We discuss a…

We point out that a new mechanism for radiation should exist if the Bohm theory of quantum mechanics is taken seriously. By traversing a quantum potential, an electron will necessarily be accelerated and radiate. For an illustration, we…

Quantum Physics · Physics 2014-03-06 Pisin Chen

The use of Bohmian mechanics as a practical tool for modeling non-relativistic quantum phenomena of matter provides clear evidence of its success, not only as a way to interpret the foundations of quantum mechanics, but also as a…

Quantum Physics · Physics 2026-04-28 Juan José Seoane , Abdelilah Benali , Xavier Oriols

A notorious problem in high-resolution biological electron microscopy is radiation damage to the specimen caused by probe electrons. Hence, acquisition of data with minimal number of electrons is of critical importance. Quantum approaches…

Quantum Physics · Physics 2014-03-05 Hiroshi Okamoto , Yukinori Nagatani

A practical quantum measurement method based on the quantum nature of anti-bunching photon emission has been developed to detect single particles without the restriction of the diffraction limit. By simultane- ously counting the…

Quantum Physics · Physics 2013-05-24 Jin-Ming Cui , Fang-Wen Sun , Xiang-Dong Chen , Zhao-Jun Gong , Guang-Can Guo

A variational method is discussed, based on the principle of minimal variance. The method seems to be suited for gauge interacting fermions, and the simple case of quantum electrodynamics is discussed in detail. The issue of renormalization…

High Energy Physics - Phenomenology · Physics 2014-01-10 Fabio Siringo

Current carrying chiral edge states in quantum Hall systems have fascinating properties that are usually studied by electron spectroscopy and interferometry. Here we demonstrate that electron occupation, current, and electron coherence in…

Mesoscale and Nanoscale Physics · Physics 2024-04-19 Ashutosh Singh , Maria Sebastian , Mikhail Tokman , Alexey Belyanin

Electron microscopy is a powerful tool for studying the properties of materials down to their atomic structure. In many cases, the quantitative interpretation of images requires simulations based on atomistic structure models. These…

Friction incorporates the close connection between classical mechanics in irreversible thermodynamics. The translation to a quantum mechanical foundation is not trivial and requires a generalization of the Lagrange function. A change to…

Medical Physics · Physics 2015-02-02 W. Ulmer

We show that negative refraction with minimal absorption can be obtained by means of quantum interference effects similar to electromagnetically induced transparency. Coupling a magnetic dipole transition coherently with an electric dipole…

Quantum Physics · Physics 2009-11-13 Jürgen Kästel , Michael Fleischhauer , Susanne F. Yelin , Ronald L. Walsworth

Important recent advances in transmission electron microscopy instrumentation and capabilities have made it indispensable for atomic-scale materials characterization. At the same time, the availability of two-dimensional materials has…

Materials Science · Physics 2021-05-04 Toma Susi , Jannik C. Meyer , Jani Kotakoski
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