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Recent studies have demonstrated the diagnostic and prognostic values of global glomerulosclerosis (GGS) in IgA nephropathy, aging, and end-stage renal disease. However, the fine-grained quantitative analysis of multiple GGS subtypes (e.g.,…

Image and Video Processing · Electrical Eng. & Systems 2022-02-02 Yuzhe Lu , Haichun Yang , Zuhayr Asad , Zheyu Zhu , Tianyuan Yao , Jiachen Xu , Agnes B. Fogo , Yuankai Huo

Glaucoma is a severe blinding disease, for which automatic detection methods are urgently needed to alleviate the scarcity of ophthalmologists. Many works have proposed to employ deep learning methods that involve the segmentation of optic…

Image and Video Processing · Electrical Eng. & Systems 2022-09-26 Yanni Wang , Gang Yang , Dayong Ding , Jianchun Zao

There has been a long pursuit for precise and reproducible glomerular quantification on renal pathology to leverage both research and practice. When digitizing the biopsy tissue samples using whole slide imaging (WSI), a set of serial…

Computer Vision and Pattern Recognition · Computer Science 2021-03-29 Ruining Deng , Haichun Yang , Aadarsh Jha , Yuzhe Lu , Peng Chu , Agnes B. Fogo , Yuankai Huo

Accurate fine-grained segmentation of the renal vasculature is critical for nephrological analysis, yet it faces challenges due to diverse and insufficiently annotated images. Existing methods struggle to accurately segment intricate…

Computer Vision and Pattern Recognition · Computer Science 2025-02-11 Yitian Long , Zhongze Wu , Xiu Su , Lining Yu , Ruining Deng , Haichun Yang , Yuankai Huo

Semantic segmentation under domain shift remains a fundamental challenge in computer vision, particularly when labelled training data is scarce. This challenge is particularly exemplified in histopathology image analysis, where the same…

Computer Vision and Pattern Recognition · Computer Science 2025-10-31 Zeeshan Nisar , Friedrich Feuerhake , Thomas Lampert

The performance of machine learning algorithms, when used for segmenting 3D biomedical images, does not reach the level expected based on results achieved with 2D photos. This may be explained by the comparative lack of high-volume,…

Computer Vision and Pattern Recognition · Computer Science 2023-08-04 Willy Kuo , Diego Rossinelli , Georg Schulz , Roland H. Wenger , Simone Hieber , Bert Müller , Vartan Kurtcuoglu

Chronic kidney disease (CKD) is a major global health issue, affecting over 10% of the population and causing significant mortality. While kidney biopsy remains the gold standard for CKD diagnosis and treatment, the lack of comprehensive…

Purpose: To improve kidney segmentation in clinical ultrasound (US) images, we develop a new graph cuts based method to segment kidney US images by integrating original image intensity information and texture feature maps extracted using…

Computer Vision and Pattern Recognition · Computer Science 2017-06-13 Qiang Zheng , Steven Warner , Gregory Tasian , Yong Fan

Segmenting histology images into diagnostically relevant regions is imperative to support timely and reliable decisions by pathologists. To this end, computer-aided techniques have been proposed to delineate relevant regions in scanned…

Kidney abnormality segmentation has important potential to enhance the clinical workflow, especially in settings requiring quantitative assessments. Kidney volume could serve as an important biomarker for renal diseases, with changes in…

Glomerulosclerosis, interstitial fibrosis, and tubular atrophy (IFTA) are histologic indicators of irrecoverable kidney injury. In standard clinical practice, the renal pathologist visually assesses, under the microscope, the percentage of…

Tissues and Organs · Quantitative Biology 2021-06-23 Brandon Ginley , Kuang-Yu Jen , Avi Rosenberg , Felicia Yen , Sanjay Jain , Agnes Fogo , Pinaki Sarder

We present our novel deep multi-task learning method for medical image segmentation. Existing multi-task methods demand ground truth annotations for both the primary and auxiliary tasks. Contrary to it, we propose to generate the…

Image and Video Processing · Electrical Eng. & Systems 2022-04-06 Binod Bhattarai , Ronast Subedi , Rebati Raman Gaire , Eduard Vazquez , Danail Stoyanov

Objective: A new image instance segmentation method is proposed to segment individual glands (instances) in colon histology images. This process is challenging since the glands not only need to be segmented from a complex background, they…

Computer Vision and Pattern Recognition · Computer Science 2017-11-27 Yan Xu , Yang Li , Yipei Wang , Mingyuan Liu , Yubo Fan , Maode Lai , Eric I-Chao Chang

Renal biopsies are the gold standard for the diagnosis of kidney diseases. Lesion scores made by renal pathologists are semi-quantitative and exhibit high inter-observer variability. Automating lesion classification within segmented…

Computer Vision and Pattern Recognition · Computer Science 2024-12-19 Zhan Xiong , Junling He , Pieter Valkema , Tri Q. Nguyen , Maarten Naesens , Jesper Kers , Fons J. Verbeek

Kidney volume is greatly affected in several renal diseases. Precise and automatic segmentation of the kidney can help determine kidney size and evaluate renal function. Fully convolutional neural networks have been used to segment organs…

Image and Video Processing · Electrical Eng. & Systems 2020-09-02 Omid Bazgir , Kai Barck , Richard A. D. Carano , Robby M. Weimer , Luke Xie

Pathological glomerulus classification plays a key role in the diagnosis of nephropathy. As the difference between different subcategories is subtle, doctors often refer to slides from different staining methods to make decisions. However,…

Computer Vision and Pattern Recognition · Computer Science 2019-03-08 Bingzhe Wu , Xiaolu Zhang , Shiwan Zhao , Lingxi Xie , Caihong Zeng , Zhihong Liu , Guangyu Sun

Comprehensive semantic segmentation on renal pathological images is challenging due to the heterogeneous scales of the objects. For example, on a whole slide image (WSI), the cross-sectional areas of glomeruli can be 64 times larger than…

Image and Video Processing · Electrical Eng. & Systems 2023-01-20 Ruining Deng , Quan Liu , Can Cui , Tianyuan Yao , Jun Long , Zuhayr Asad , R. Michael Womick , Zheyu Zhu , Agnes B. Fogo , Shilin Zhao , Haichun Yang , Yuankai Huo

Understanding the anatomy of renal pathology is crucial for advancing disease diagnostics, treatment evaluation, and clinical research. The complex kidney system comprises various components across multiple levels, including regions…

Image and Video Processing · Electrical Eng. & Systems 2024-03-22 Ruining Deng , Quan Liu , Can Cui , Tianyuan Yao , Jialin Yue , Juming Xiong , Lining Yu , Yifei Wu , Mengmeng Yin , Yu Wang , Shilin Zhao , Yucheng Tang , Haichun Yang , Yuankai Huo

In this paper, we formulated the kidney segmentation task in a coarse-to-fine fashion, predicting a coarse label based on the entire CT image and a fine label based on the coarse segmentation and separated image patches. A key difference…

Image and Video Processing · Electrical Eng. & Systems 2019-08-30 Yue Zhang , Jiong Wu , Yu Zhou , Yifan Chen , Xiaoying Tang

In this paper, we propose a new image instance segmentation method that segments individual glands (instances) in colon histology images. This is a task called instance segmentation that has recently become increasingly important. The…

Computer Vision and Pattern Recognition · Computer Science 2016-07-20 Yan Xu , Yang Li , Mingyuan Liu , Yipei Wang , Yubo Fan , Maode Lai , Eric I-Chao Chang