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Covariate-adaptive randomization is widely employed to balance baseline covariates in interventional studies such as clinical trials and experiments in development economics. Recent years have witnessed substantial progress in inference…

Methodology · Statistics 2024-05-30 Jiahui Xin , Hanzhong Liu , Wei Ma

Scaling laws in ecology, intended both as functional relationships among ecologically-relevant quantities and the probability distributions that characterize their occurrence, have long attracted the interest of empiricists and…

Populations and Evolution · Quantitative Biology 2017-10-19 Silvia Zaoli , Andrea Giometto , Amos Maritan , Andrea Rinaldo

In Bayesian meta-analysis, the specification of prior probabilities for the between-study heterogeneity is commonly required, and is of particular benefit in situations where only few studies are included. Among the considerations in the…

Methodology · Statistics 2023-06-02 Christian Röver , Sibylle Sturtz , Jona Lilienthal , Ralf Bender , Tim Friede

Background: Heritability is a central measure in genetics quantifying how much of the variability observed in a trait is attributable to genetic differences. Existing methods for estimating heritability are most often based on random-effect…

Applications · Statistics 2022-08-26 The Tien Mai , Paul Turner , Jukka Corander

Inter-rater reliability (IRR), which is a prerequisite of high-quality ratings and assessments, may be affected by contextual variables such as the rater's or ratee's gender, major, or experience. Identification of such heterogeneity…

Methodology · Statistics 2023-02-17 Patrícia Martinková , František Bartoš , Marek Brabec

One size fits all approaches to medicine have become a thing of the past as the understanding of individual differences grows. The paper introduces a test for the presence of heterogeneity in treatment effects in a clinical trial.…

Several factors affect the structure of communities, including biological, physical and chemical phenomena, impacting the quantification of biodiversity, measured by diversity indexes such as Shannon's entropy. Then, once a point estimate…

Quantitative Methods · Quantitative Biology 2022-04-22 Gabriel R. Palma , Silvio S. Zocchi , Wesley A. C. Godoy , Jorge A. Wiendl

An organism that is newly introduced into an existing population has a survival probability that is dependent on both the population density of its environment and the competition it experiences with the members of that population.…

Populations and Evolution · Quantitative Biology 2024-12-17 Jason M. Gray , Rowan J. Barker-Clarke , Jacob G. Scott , Michael Hinczewski

Geographic ranges of communities of species evolve in response to environmental, ecological, and evolutionary forces. Understanding the effects of these forces on species' range dynamics is a major goal of spatial ecology. Previous…

Populations and Evolution · Quantitative Biology 2022-02-02 Farshad Shirani , Judith R. Miller

Human associated microbial communities exert tremendous influence over human health and disease. With modern metagenomic sequencing methods it is possible to follow the relative abundance of microbes in a community over time. These…

Quantitative Methods · Quantitative Biology 2015-06-18 Charles K. Fisher , Pankaj Mehta

The evolution of antimicrobial resistance generally occurs in an environment where antimicrobial concentration is variable, which has dramatic consequences on the microorganisms' fitness landscape, and thus on the evolution of resistance.…

Biological Physics · Physics 2018-10-23 Loïc Marrec , Anne-Florence Bitbol

Despite major environmental and genetic differences, microbial metabolic networks are known to generate consistent physiological outcomes across vastly different organisms. This remarkable robustness suggests that, at least in bacteria,…

Molecular Networks · Quantitative Biology 2022-05-24 Anna Paola Muntoni , Alfredo Braunstein , Andrea Pagnani , Daniele De Martino , Andrea De Martino

The observation that phenotypic variability is ubiquitous in isogenic populations has led to a multitude of experimental and theoretical studies seeking to probe the causes and consequences of this variability. Whether it be in the context…

Populations and Evolution · Quantitative Biology 2022-02-18 Ethan Levien , Jiseon Min , Jane Kondev , Ariel Amir

Abundance data are used in ecology for species monitoring and conservation. These count data often display several specific characteristics like numerous missing data, high variance, and a high proportion of zeros, particularly when…

Standard high-dimensional factor models assume that the comovements in a large set of variables could be modeled using a small number of latent factors that affect all variables. In many relevant applications in economics and finance,…

Econometrics · Economics 2022-02-08 Antoine Djogbenou , Razvan Sufana

Heterogeneity in physical and functional characteristics of cells (e.g. size, cycle time, growth rate, protein concentration) proliferates within an isogenic population due to stochasticity in intracellular biochemical processes and in the…

Cell Behavior · Quantitative Biology 2021-02-02 Harsh Vashistha , Maryam Kohram , Hanna Salman

The process of infection of a host is complex, influenced by factors such as microbial variation within and between hosts as well as differences in dose across hosts. This study uses dose-response and within-host microbial infection models…

Populations and Evolution · Quantitative Biology 2025-04-10 Francisco J. Perez-Reche

Before deploying a black-box model in high-stakes problems, it is important to evaluate the model's performance on sensitive subpopulations. For example, in a recidivism prediction task, we may wish to identify demographic groups for which…

Methodology · Statistics 2023-06-09 John J. Cherian , Emmanuel J. Candès

Difficulties identifying appropriate biodiversity impact metrics remain a major barrier to inclusion of biodiversity considerations in environmentally responsible investment. We propose and analyse a simple science-based local metric: the…

Populations and Evolution · Quantitative Biology 2023-03-21 Axel G. Rossberg , Jacob D. O'Sullivan , Svetlana Malysheva , Nadav M. Shnerb

We develop a theoretical framework to understand the persistence and coexistence of competitive species in a spatially explicit metacommunity model with a heterogeneous dispersal kernel. Our analysis, based on methods from the physics of…

Populations and Evolution · Quantitative Biology 2025-03-14 Davide Bernardi , Giorgio Nicoletti , Prajwal Padmanabha , Samir Suweis , Sandro Azaele , Andrea Rinaldo , Amos Maritan
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